Optimization of Protocell of Silica Nanoparticles Using 32 Factorial Designs

Kaur, Gunjeet; Rath, Goutam; Heer, Hemraj; Goyal, Amit K.

doi:10.1208/s12249-011-9741-8

Cited by 10 publications

(4 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The low value of C.V. indicated a high reliability of the experiment 27, 28 . Adequate precision measured the signal to noise ratio, where ratio greater than 4 (R1, 34.868 and R2, 27.307) is desirable 29 .…”

Section: Resultsmentioning

confidence: 99%

Optimization of hot melt extrusion parameters for sphericity and hardness of polymeric face-cut pellets

Alshetaili

Almutairy

Alshahrani

et al. 2016

Drug Development and Industrial Pharmacy

View full text Add to dashboard Cite

The aim of this study was to formulate face-cut, melt extruded pellets and to optimize hot melt process parameters to obtain maximized sphericity and hardness by utilizing Soluplus® as a polymeric carrier and carbamazepine (CBZ) as a model drug. Thermal gravimetric analysis (TGA) was used to detect thermal stability of CBZ. The Box-Behnken design for response surface methodology was developed using three factors, processing temperature (°C), feeding rate (%), and screw speed (rpm), which resulted in 17 experimental runs. The influence of these factors on pellet sphericity and mechanical characteristics was assessed and evaluated for each experimental run. Pellets with optimal sphericity and mechanical properties were chosen for further characterization. This included differential scanning calorimetry, drug release, hardness friability index (HFI), flowability, bulk density, tapped density, Carr’s index, and fourier transform infrared radiation (FTIR) spectroscopy. TGA data showed no drug degradation upon heating to 190°C. Hot melt extrusion (HME) processing conditions were found to have a significant effect on the pellet shape and hardness profile. Pellets with maximum sphericity and hardness exhibited no crystalline peak after extrusion. The rate of drug release was affected mainly by pellet size, where smaller pellets released the drug faster. All optimized formulations were found to be of superior hardness and not friable. The flow properties of optimized pellets were excellent with high bulk and tapped density.

show abstract

Section: Resultsmentioning

confidence: 99%

Optimization of hot melt extrusion parameters for sphericity and hardness of polymeric face-cut pellets

Alshetaili

Almutairy

Alshahrani

et al. 2016

Drug Development and Industrial Pharmacy

View full text Add to dashboard Cite

show abstract

“…RSM examines the simultaneous interactive effect of input factors to achieve an optimum response, which is not achievable using conventional experimental methods (Kamani et al 2018). The RSM design models include the linear, mean, 2-factor interaction, 2FI, quadratic, cubic, quartic, fifth, and sixth equations (Croarkin et al 2006;Kaur et al 2012). RSM was used to evaluate the effect of the input factors: the changing electrode length (l e ), soil depth (d s ), and anode to cathode distance (d A↔E ) on the responses: the PI and SP values of the EK treated soils.…”

Section: Response Surface Methodology Rsmmentioning

confidence: 99%

Performance of electrokinetic treatment of fine-grained problematic soils

Abiodun¹,

Nalbantoğlu²

2021

JER is an international, peer-reviewed journal that publishes f

View full text Add to dashboard Cite

Electrokinetic (EK) treatment is an innovative, cost-effective in situ ground modification technology. The EK treatment uses a combination of low-voltage direct-current, electrodes, and ionic solutions across problematic soil to improve the ground conditions. This study aims to model the effect of changing electrode length (le) on the performance of the EK treatment on the engineering properties of fine-grained problematic soils. The consideration of the changing electrode lengths (le), varying soil depths (ds), and lengthwise anode to cathode distances (dA↔E), in the soil block samples, is in the form of the laboratory model test tank. The significant performance of the experimental tests was with changing electrode lengths of 0.25le (7.5 cm), 0.50le (15.0 cm), 0.75le (22.5 cm), and 1.0le (30.0 cm). The study analyzed the test data obtained from the Atterberg limit and one-dimensional swelling tests at different extraction points of the EK treated soils in the test tanks. Furthermore, the study carefully analyzed the effect of changing electrode length (le) on the performance of the EK treatment. The results of the Design of Experiment (DOE) model analysis revealed that the effect of changing electrode length (le) on the plasticity index (PI), and swelling potential (SP) of the EK treated soils, was significant. For a specific soil depth (ds), the electrode lengths (le) of 0.50le and 0.75le were significantly effective in reducing the PI, and the SP of the EK treated soils. Unlike other studies in the literature, the use of DOE analysis in the present study enabled the detection of the significant input factors and their interactive effects on the PI and the SP, thus, enabling the practicing engineers to navigate accurate design models for large in situ applications.

show abstract

“…Some significant benefits follow below. [39][40][41][42] 1. Enhanced Product Quality and Consistency: QbD encourages a thorough understanding of the relationships between CPPs and CQAs.…”

Section: Benefits Of Implementing Qbd In Sublingual Tablet Developmentmentioning

confidence: 99%

Enhancing Sublingual Tablet Quality through QbD: Current Trends and Insights"

Joshi,

Choudhary

2023

Precision Nanomedicine

View full text Add to dashboard Cite

The field of pharmaceutical development has witnessed a significant shift toward implementing Quality by Design (QbD) principles to enhance the quality, safety, and efficacy of various drug delivery systems. As a promising alternative to traditional oral dosage forms, sublingual tablets have gained attention for their rapid onset of action and improved patient compliance. This re-view article aims to provide a comprehensive overview of the fundamental principles of QbD and its relevance in the context of sublingual tablets. It delves into the intricate relationship between Critical Quality Attributes (CQAs) and Critical Process Parameters (CPPs), emphasizing the necessity of a systematic approach to achieving product excellence. Furthermore, the article highlights the benefits of implementing QbD in sublingual tablet development, potential challenges, and the regulatory landscape for QbD in pharmaceutical development.

show abstract

Optimization of Protocell of Silica Nanoparticles Using 32 Factorial Designs

Cited by 10 publications

References 10 publications

Optimization of hot melt extrusion parameters for sphericity and hardness of polymeric face-cut pellets

Optimization of hot melt extrusion parameters for sphericity and hardness of polymeric face-cut pellets

Performance of electrokinetic treatment of fine-grained problematic soils

Enhancing Sublingual Tablet Quality through QbD: Current Trends and Insights"

Contact Info

Product

Resources

About