Optimization of ScCO2 Extraction of Rambutan Seed Oil Using Response Surface Methodology

Yoswathana, Nuttawan

doi:10.7763/ijcea.2013.v4.291

Cited by 7 publications

(6 citation statements)

References 20 publications

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“…In contrast, increasing the extraction temperature at highest ethanol concentrations resulted to decreased, TF values. This phenomenon can be explained by the higher movement of the particles which causes plant tissue to rupture and hence allowing higher solubility of solvent until it starts to degrade to a lower value as it had achieved the stable state [ 26 ]. The results obtained for flavonoids are in agreement with the previous report from Cryptotaenia japonica hassk by Lu et al [ 27 ] where the flavonoid content increased when the temperature of extraction increased to below 70 °C and exhibited a decreasing trend above the optimum level of temperature.…”

Section: Resultsmentioning

confidence: 99%

Optimization of phenolics and flavonoids extraction conditions of Curcuma Zedoaria leaves using response surface methodology

Azahar

Gani

Mokhtar

2017

Chemistry Central Journal

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This study focused on maximizing the extraction yield of total phenolics and flavonoids from Curcuma Zedoaria leaves as a function of time (80–120 min), temperature (60–80 °C) and ethanol concentration (70–90 v/v%). The data were subjected to response surface methodology (RSM) and the results showed that the polynomial equations for all models were significant, did not show lack of fit, and presented adjusted determination coefficients (R2) above 99%, proving their suitability for prediction purposes. Using desirability function, the optimum operating conditions to attain a higher extraction of phenolics and flavonoids was found to be 75 °C, 92 min of extraction time and 90:10 of ethanol concentration ratios. Under these optimal conditions, the experimental values for total phenolics and flavonoids of Curcuma zedoaria leaves were 125.75 ± 0.17 mg of gallic acid equivalents and 6.12 ± 0.23 mg quercetin/g of extract, which closely agreed with the predicted values. Besides, in this study, the leaves from Curcuma zedoaria could be considered to have the strong antioxidative ability and can be used in various cosmeceuticals or medicinal applications.

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Section: Resultsmentioning

confidence: 99%

Optimization of phenolics and flavonoids extraction conditions of Curcuma Zedoaria leaves using response surface methodology

Azahar

Gani

Mokhtar

2017

Chemistry Central Journal

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“…Surface methodology was a good tool for optimization of extraction conditions [17]. Table 2 presents the experimental design and corresponding response data for the extraction of the andrographolid.…”

Section: Resultsmentioning

confidence: 99%

“…Response Surface Methodology (RSM) is widely employed for constructing and exploring estimated functional relationship between a response variable and design variables [17]. The main advantage of RSM is the reduced number of experimental trials needed to evaluate multiple parameters and their interactions.…”

Section: Introductionmentioning

confidence: 99%

The Application of Response Surface Methodology in Hydrotropic Microwave Assisted Extraction of Andrographolide

Hartati¹,

Kurniasari²,

Anas³

2014

AJOCT

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Abstract:Andrographolide of Andrographis paniculata is reported has a broad category of pharmacological activity. Various attemps have been done in order to improve the andrographolide extraction performance. Hydrotropic-microwave assisted extraction provides an effective method in andrographolide extraction. In this study, Response Surface Methodology (RSM) along with central composite design (CCD) was applied to optimize the hydrotropicmicrowave assisted extraction of andrographilde. The effect of extraction time (X 1 ), solid-liquid ratio (X 2 ), and hydrotropes concentration (X 3 ) were investigated. The result showed that the most suitable condition for extraction of andrographolide was found to be extraction at 32,5 minutes, solid liquid ratio of 0,095 and hydrotropes concentration of 4M. The maximum extraction percentage experimentally (5,45%) was found to be very close to its predicted value. It was also found that hydrotropes concentration was the most influencing variable. The mathematical model for the hydrotropic-microwave assisted extraction is : Y = 4.812 + 1.66 X 1 − 2.366 X 1 2 + 0.478 X 2 − 2.473 X 2 2 + 2.216 X 3 − 0.983 X 3 2

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“…It is encouraging to compare Figure 3 with that found by Azahar et al (2017) whose found out that the flavonoid content increased as the temperature approached 70℃, and gradually decline as the temperature rise above its optimum temperature. A likely explanation is that higher temperature cause plant tissue rupture, thus solvent was easily to dissolved and degrade active compounds in the plant (Azahar et al, 2017;Yoswathana, 2013). It is apparent from Figure 3 that the best temperature for flavonoid extraction is 60˚C regardless of whether the seeds were treated or not prior to extraction.…”

Section: The Effect Of Extraction Temperature On Total Flavanoid Content (Tfc)mentioning

confidence: 99%

Effect of Extraction Time and Temperature on Total Flavanoid Contents of Petai Belalang (Leucaena leucocephala) Seed Pretreated by Enzymatic Hydrolysis

Hamidi¹,

Alwi²,

Tarmalingam³

et al. 2021

JST

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The abundant availability of Leucaena leucocephala (petai belalang) in Malaysia was one of the contributing factors of this research. The phytochemicals obtained from this plant will contribute towards many fields mainly medicine and it becomes more favorable as compared to the modern medicines used these days. Diseases such as cancer, high blood pressure and diabetes are very crucial, and it occurs frequently among all ages of citizens in Malaysia. Therefore, phytochemicals in this plant can be a great substitute of modern medicines. However, lignin is known to interfere with the cell wall polysaccharides digestion, and hence considered as an anti-quality component in forages. To improve phytochemicals extraction, an effective degradation method of lignin is in demand. Thus, the goal of the present study was to investigate the feasibility of using enzymatic hydrolysis by laccase from Trametes versicolor (LTV) to breakdown lignin using mild reaction condition. To clarify the effect of enzymatic hydrolysis, a preliminary study on the percentage of lignin removal was conducted that taking the effect of LTV concentration, incubation temperature and time into consideration. The results were then used to analyze total flavonoid contents (TFC) of L.leucocephala seed after the extraction by using microwave-assisted hydrodistillation (MAHD) method. In view of this, extraction temperature and time were varied. TFC was estimated by UV-VIS spectrophotometer for quantification by using quercetin as standard. The result emerge from this study showed that the TFC was high in the extraction temperature of 60˚C in 12 min with an average of 1639 mgQE/g.d.w and the lowest TFC was recorded at 30˚C with 677 mgQE/g.d.w. Further analysis showed that enzymatic hydrolysis has assisted the extraction of flavonoids, thus, provided scientific method to extract flavonoid as an alternative therapy for various diseases.

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Optimization of ScCO2 Extraction of Rambutan Seed Oil Using Response Surface Methodology

Cited by 7 publications

References 20 publications

Optimization of phenolics and flavonoids extraction conditions of Curcuma Zedoaria leaves using response surface methodology

Optimization of phenolics and flavonoids extraction conditions of Curcuma Zedoaria leaves using response surface methodology

The Application of Response Surface Methodology in Hydrotropic Microwave Assisted Extraction of Andrographolide

Effect of Extraction Time and Temperature on Total Flavanoid Contents of Petai Belalang (Leucaena leucocephala) Seed Pretreated by Enzymatic Hydrolysis

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