As the International Technology Roadmap for Semiconductors (ITRS) demands an increase of transistor density in the chip, the size of transistors has been continuously shrunk. In this evolution of transistor structure, different strain engineering methods were introduced to induce strain in the channel region. One of the most effective methods is applying embedded SiGe as stressor material in source and drain (S/D) regions by using selective epitaxy. This chapter presents an overview of implementation, modeling, and pattern dependency of selective epitaxy for S/D application in CMOS. The focus is also on the wafer in and ex situ cleaning prior to epitaxy, integrity of gate, and selectivity mode.