Optimization of selectivity in micellar chromatographic procedures for the determination of drugs in urine by direct injection

Love, L. J. Cline.; Fett, Joseph J.

doi:10.1016/0731-7085(91)80201-j

Cited by 47 publications

(1 citation statement)

References 21 publications

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“…The retention of solutes is modified by the composition of eluents (17). The proposed method permits separation and quantitation of benzyl alcohol and benzaldehyde in parenteral formulations.…”

Section: Resultsmentioning

confidence: 99%

Micellar liquid chromatographic analysis of benzyl alcohol and benzaldehyde in injectable formulations

Rizk¹,

Ibrahim²,

Hefnawy³

et al. 2007

Acta Pharmaceutica

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Micellar liquid chromatographic analysis of benzyl alcohol and benzaldehyde in injectable formulationsAn accurate, sensitive and selective reversed-phase micellar liquid chromatographic method was developed for simultaneous determination of benzyl alcohol and benzaldehyde. This method was applied in different injectable formulations containing diclofenac, piroxicam, lincomycin and clindamycin. The method showed excellent linearity in the range of 10-100 μg mL-1and 1-20 μg mL-1with the limit of detection (S/N = 3) 0.25 μg mL-1(2.3 x 10-6mol L-1) and 0.12 μg mL-1(1.13 x 10-6mol L-1) for benzyl alcohol and benzaldehyde, respectively. The suggested method was successfully applied to the analysis of the studied drugs in bulk with average recoveries of 100.1 ± 1.0% for benzyl alcohol and 100.4 ± 1.6% for benzaldehyde, and to the determination of benzyl alcohol and benzaldehyde in injectable formulations with the respective average recoveries of 99.8 ± 0.3 and 100.0 ± 0.4%.

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Section: Resultsmentioning

confidence: 99%

Micellar liquid chromatographic analysis of benzyl alcohol and benzaldehyde in injectable formulations

Rizk¹,

Ibrahim²,

Hefnawy³

et al. 2007

Acta Pharmaceutica

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Micellar Liquid Chromatography: Fundamentals

García-Álvarez-Coque

Ruiz-Ángel

Carda‐Broch

2015

Analytical Separation Science

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The reversed phase liquid chromatography (RPLC) mode with surfactant above the critical micellar concentration (CMC) has been called micellar liquid chromatography (MLC). In pure micellar systems, the retention behavior is explained by considering three phases or environments: surfactant‐modified stationary phase, bulk aqueous solvent, and micellar pseudo‐phase. Surfactant adsorption on the porous RPLC packing affects chromatographic retention, owing to the change of diverse surface properties of the stationary phase. In pure micellar systems, the retention behavior is explained by considering three phases or environments: surfactant‐modified stationary phase, bulk aqueous solvent, and micellar pseudo‐phase. In pure micellar mobile phases, water‐insoluble nonpolar solutes or species strongly bound to surfactant monomers do not participate significantly in the aqueous environment of the three‐phase partitioning scheme. Some of the solutions proposed along the years to overcome these limitations have favored the potential of the technique, but they have not resulted in an extensive use.

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Micellar Liquid Chromatography: Method Development and Applications

García-Álvarez-Coque

Ruiz-Ángel

Carda‐Broch

2015

Analytical Separation Science

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After more than three decades of experience, micellar liquid chromatography ( MLC ) seems to be an alternative to conventional reversed phase liquid chromatography ( RPLC ) with hydro‐organic mobile phases, with increasing interest in “green” chemistry. Most MLC procedures use hybrid micellar mobile phases containing a surfactant (frequently sodium dodecyl sulfate) above the critical micellar concentration and a relatively small amount of organic solvent to increase the elution strength and improve the efficiencies. Practical indications a chromatographer should consider in MLC when developing an analytical procedure, related to the mobile‐phase preparation and the cautions with the stationary phase, are discussed. The retention models to be considered for optimizing the best experimental conditions, taking the concentrations of surfactant and organic solvent and the pH as factors, and the diverse detection modes that have been used in MLC are described. The direct injection capability of MLC after simple filtration is highlighted. A compilation of analytical methods in MLC is given, mainly related to the determination of drugs in formulations and physiological fluids, oriented to follow the parent drug and/or its metabolites.

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Optimization of selectivity in micellar chromatographic procedures for the determination of drugs in urine by direct injection

Cited by 47 publications

References 21 publications

Micellar liquid chromatographic analysis of benzyl alcohol and benzaldehyde in injectable formulations

Micellar liquid chromatographic analysis of benzyl alcohol and benzaldehyde in injectable formulations

Micellar Liquid Chromatography: Fundamentals

Micellar Liquid Chromatography: Method Development and Applications

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