2021
DOI: 10.1002/mrm.29063
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Optimization of spin‐lock times in T mapping of knee cartilage: Cramér‐Rao bounds versus matched sampling‐fitting

Abstract: The spin-lattice relaxation time in the rotating frame (T 1ρ ) has shown sensitiveness to loss of proteoglycan content in the cartilage 1,2 and T 1ρ relaxation mapping can be useful for early detection of osteoarthritis (OA). 3 To produce good and stable T 1ρ maps, many T 1ρ -weighted images must be acquired, taking a long acquisition time if a good signalto-noise ratio (SNR) and small variance in the estimated parameters are desired.

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Cited by 15 publications
(42 citation statements)
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“…All the MRI scans were performed on a 3 T, whole-body clinical MRI scanner (Prisma, Siemens Healthcare, Erlangen, Germany) with a 15-channel transmit/receive knee coil (QED, Cleveland OH). The 3D-T1ρ-weighted datasets were acquired using a modified 3D Cartesian ultra-fast spoiled gradient echo (Turbo FLASH) sequence 12 for variable TSL as shown in supporting information Fig. S1 .…”
Section: Methodsmentioning
confidence: 99%
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“…All the MRI scans were performed on a 3 T, whole-body clinical MRI scanner (Prisma, Siemens Healthcare, Erlangen, Germany) with a 15-channel transmit/receive knee coil (QED, Cleveland OH). The 3D-T1ρ-weighted datasets were acquired using a modified 3D Cartesian ultra-fast spoiled gradient echo (Turbo FLASH) sequence 12 for variable TSL as shown in supporting information Fig. S1 .…”
Section: Methodsmentioning
confidence: 99%
“…Therefore, the optimization of sampling schedules is critical for these models. In this paper, we extend Zibetti et al’s 12 approach to the CRLB and MCRLB optimization of TSL sampling schedules for the bi-exponential and stretched-exponential models. Another difference from previous works is the use of different weights for each of the model’s parameters.…”
Section: Introductionmentioning
confidence: 97%
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