Optimization of supercritical fluid extraction of dihydrotanshinone, cryptotanshinone, tanshinone I, and tanshinone IIA from Salvia miltiorrhiza with a peanut oil modifier

Fikri, Ilham; Yulianah, Yulianah; Lin, Tzu-Che; Lin, Ru-Wei; UeiChern, Chen; Lay, Horng‐Liang

doi:10.1016/j.cherd.2022.02.021

Cited by 7 publications

(2 citation statements)

References 33 publications

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“…Today, various techniques are used for obtaining various sage products [43] and are chosen depending on the desired profile of sage's bioactive compounds in an extract, and the most used techniques have been recently extensively summarized [16]. Currently, the most employed extraction methods (Table 1) are represented by hydrodistillation (HD) [44], steam distillation (SD) [45], ultrasound-assisted extraction (UAE) [46], sonohydrodistillation (SHD) [47], microwave-assisted extraction (MAE) [48] including microwave-assisted hydrodistillation (MHD or MAHD) [49,50], solid-liquid extraction (SLE) [51], Soxhlet extraction (SE) [52], infusion [53], freeze drying (FD) [54,55], solventfree microwave-assisted extraction (SFME) [56], supercritical fluid extraction (SFE) [57], subcritical water extraction (SCWE) [58], and supercritical CO 2 extraction (SC-CO 2 ) [59,60]. The choice of extraction technique was seen to influence phenolic acids and flavonoid composition, where ultrasound-assisted extraction (UAE) gave the highest concentration [61].…”

Section: Extraction Methodsmentioning

confidence: 99%

An Update on Recent Studies Focusing on the Antioxidant Properties of Salvia Species

Iacopetta,

Ceramella,

Scumaci

et al. 2023

Antioxidants

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Nutrition has crucial effects and a significant role in disease prevention. Recently, nutraceuticals have attracted much attention in scientific research due to their pleiotropic effects and relatively non-toxic behavior. Among the biological effects displayed by plants belonging to the Lamiaceae family, such as antibacterial, anticancer, anti-inflammatory, and anticholinesterase, sage is well known for its antioxidant properties and is a rich source of numerous compounds that are biologically active, amongst them polyphenols, with more than 160 types identified. In this review we summarized some of the significant studies published in the last decade reporting the most employed extraction methods and the different assays that are useful for establishing the antioxidant properties of some sage species. Even though the scientific literature contains plenty of data regarding the antioxidant properties of many sage species, further studies are needed in order to gain a deeper understanding of the mechanism of action and the compounds responsible for their antioxidant activity. Finally, it should be taken into account that the data on the antioxidant properties of sage extracts are often difficult to compare with each other, since a series of variables in the extraction procedures, the type of assay used, and standardization may affect the final result.

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Section: Extraction Methodsmentioning

confidence: 99%

An Update on Recent Studies Focusing on the Antioxidant Properties of Salvia Species

Iacopetta,

Ceramella,

Scumaci

et al. 2023

Antioxidants

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show abstract

“…The high-pressure gradients during pressure release can produce extracts free from living creatures and spores with a longer shelf life than the extract using standard solvents (Santo et al, 2021). The main drawbacks of Supercritical Fluid Extraction (SCFE) are the use of critical pressure that prevents system development for production scale, expensive equipment price, and low dielectric constants (Fikri et al, 2022). CO2 and extractor storage tanks must be isolated correctly and equipped with a safety system.…”

Section: Introductionmentioning

confidence: 99%

Design and Manufacture of a Supercritical Co2 Liquid Extraction Machine for Extracting Bioactive Compounds

ARGO,

SYECH,

RIJADI

et al. 2023

INMATEH

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Bioactive compounds in animal and plant cells have many benefits for human health, such as antioxidants, antibacterial, anti-inflammatory, and anticancer. Extraction and separation of bioactive compounds from other compounds is an important step, and commonly, conventional methods are used, but these methods have disadvantages, like producing unwanted compounds. Alternative methods can be conducted using supercritical fluid extraction, but this equipment is expensive and has a small capacity. So, this study aims to produce functional and structural designs and manufacture supercritical fluid extraction machines using carbon dioxide solvents (CO2) operating with a semi-continuous system. This research succeeded in designing and manufacturing a supercritical fluid extraction machine using carbon dioxide (CO2) solvent that operates in a semi-continuous system for the extraction of bioactive compounds, with main components including cover frames, supercritical extractor chamber, low and high-pressure CO2 tubes, compressors and boosters, pipelines, direct valves, manometers, heating, cooler, and expanders, result from reservoirs and automatic control. Moreover, the preliminary simulation test studies revealed that the supercritical extractor chamber could withstand an absolute pressure of 1000 bar, a temperature of 300°C, and a work capacity of 1 L. It indicated that the supercritical CO2 fluid extractor system was performing well for the conditioning of the extractor chamber, which is generated using a booster and controlled by a one-way valve. Then, the extract is transferred to the separation chamber to separate the CO2 gas. Then, CO2 gas is returned to the low-pressure CO2 tubes for recycling and reuse for the following process.

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Fundamentals of supercritical fluid extraction

Santana,

Meireles

2024

Reference Module in Chemistry, Molecular Sciences and Chemical Engineering

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Optimization of supercritical fluid extraction of dihydrotanshinone, cryptotanshinone, tanshinone I, and tanshinone IIA from Salvia miltiorrhiza with a peanut oil modifier

Cited by 7 publications

References 33 publications

An Update on Recent Studies Focusing on the Antioxidant Properties of Salvia Species

An Update on Recent Studies Focusing on the Antioxidant Properties of Salvia Species

Design and Manufacture of a Supercritical Co2 Liquid Extraction Machine for Extracting Bioactive Compounds

Fundamentals of supercritical fluid extraction

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