“…Among the many classes of RSM designs, central composite design (CCD) is among the most popular methods due to its simple structure and efficiency (Correia, Gonçalves, da Cunha Jr., & Ferraresi, 2005). Based on the best of our knowledge, there are only few reports on optimization of antioxidants extraction from basil using RSM technique and pressurized liquid extraction (PLE) and maceration extraction methods (Hossain, Brunton, Martin-Diana, & Barry-Ryan, 2010;Juntachote, Berghofer, Bauer, & Siebenhandl, 2006;Vidović et al, 2012). However, no research article regarding the RSM optimization and investigation of antioxidants extraction from basil using UAE method was found.…”