Optimization of the Synthesis of Hydroxyapatite Powders for Biomedical Applications Using Taguchi's Method

Ranito, Cláudia M.S.; Nogueira, Carlos A.; Domingues, J. J. M. S.; Pedrosa, Fátima; Oliveira, Fernando A. Costa; Borges, João Paulo

doi:10.4028/www.scientific.net/msf.514-516.1025

Cited by 5 publications

(6 citation statements)

References 8 publications

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“…Briefly, the Taguchi methods are statistical methods developed by Genichi Taguchi to improve the quality of manufactured goods and more recently applied to biotechnology, marketing, and advertising [31][32][33]. Namely, Taguchi specified three possible situations: first, 'more is better' (MB), and, in the case studied here, this was the mechanical strength of the toughened scaffolds; second, 'less is better' (LB), and, in the case stuided here, this was the amount of the deposited PCL; third, on-target minimum variation (e.g.…”

Section: Taguchi Design Of the Coating Experimentsmentioning

confidence: 99%

“…A good example of the efficient analyses of various complex systems consists of a statistical experimental design and Taguchi methods [31][32][33]. The statistical experimental design can determine the factor effects on characteristic properties and select the optimum conditions for these factors.…”

Section: Introductionmentioning

confidence: 99%

“…A conventional statistical experimental design can determine the optimum conditions based on the measured values of the characteristic properties, while the Taguchi experimental design (also known as robust parameter design) does this on the basis of the variability of the characteristic properties. In other words, Taguchi methods can determine the experimental condition having the least variability as the optimum conditions [31][32][33].…”

Section: Introductionmentioning

confidence: 99%

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Toughening of porous bioceramic scaffolds by bioresorbable polymeric coatings

Dorozhkin¹,

Ajaal

2009

Proc Inst Mech Eng H

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The mechanical properties of poly(c-caprolactone) (PCL)-coated porous bioceramic scaffolds made of calcium phosphates were studied and analysed using a statistical experimental design and Taguchi methods. In this study, both the flexural strength of the coated scaffolds and the amount of deposited PCL were considered as the measured responses. A statistical experimental design using the analysis of means and orthogonal array was applied to optimize these responses. The removal technique of excess polymer solution, the concentration of PCL in the solution, a heat treatment temperature, and the number of times that the scaffolds were dipped in the solution were chosen as the significant processing variables. The removal technique of excess polymer solution and the number of times that the scaffolds were dipped in the solution showed the major effects on the flexural strength, while the technique for removal of excess polymer solution was found to have the major effect on the mass of the deposited PCL. The optimal conditions for achieving the maximal flexural strength of the coated scaffolds at the minimal amount of the deposited PCL were determined and tested. High-quality porous bioresorbable scaffolds with approximately 19 MPa flexural strength and approximately 0.4g of the total (PCL coating+calcium phosphates) mass with dimensions of 8.5 mm diameter and 13 mm width were manufactured as a result.

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Section: Taguchi Design Of the Coating Experimentsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Toughening of porous bioceramic scaffolds by bioresorbable polymeric coatings

Dorozhkin¹,

Ajaal

2009

Proc Inst Mech Eng H

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“…A good example of the efficient analyses of various complex systems comprises a statistical experimental design and Taguchi methods [25][26][27][28]. The statistical experimental design can determine the factor effects on characteristic properties and select the optimum conditions for these factors.…”

Section: Introductionmentioning

confidence: 99%

“…A conventional statistical experimental design can determine the optimum conditions based on the measured values of the characteristic properties, while the Taguchi experimental design (also known as a robust parameter design) does this on the basis of a variability of the characteristic properties. In other words, Taguchi methods can determine the experimental conditions having the least variability as the optimum conditions [25][26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Strengthening of Dense Bioceramic Samples Using Bioresorbable Polymers – A Statistical Approach

Dorozhkin¹,

Ajaal

2009

JBBTE

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Mechanical properties of bioceramics are poor and need to be improved for biomedical applications. In order to do this, bioceramics may be strengthened by bioresorbable polymers. In this study, the mechanical properties of poly(ε-caprolactone), PCL, coated dense bioceramic pellets made of silica-contained calcium phosphates were studied and analyzed using a statistical experimental design in conjunction with Taguchi methods for optimization. The aim of this experimental work was to maximize the pellet flexural strength and minimize the amount of deposited PCL. The most important factors affecting the strengthening of the ceramic pellets were evaluated. Four independent processing variables (a removal technique of an excess polymer solution, concentration of PCL in the solution, a heat treatment temperature and the number of dipping) with three levels of variability were tested using an L9 (34) orthogonal array. A statistical experimental design using the analysis of means and orthogonal array was applied to optimize the responses of these variables. The optimal conditions for achieving the maximal flexural strength of the coated pellets at the minimal amount of the deposited PCL were determined. A high quality dense bioceramic pellets with ~ 10.5 MPa flexural strength and ~ 80 μm thickness (~ 21 mg weight) of the deposited PCL coating were manufactured as a result.

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Fabrication of mechanically enhanced hydroxyapatite scaffold with the assistance of numerical analysis

Abifarin

Suleiman

Abifarin

et al. 2021

Int J Adv Manuf Technol

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Hydroxyapatite (HAp) has been found to be incompetent as it relates to its mechanical integrity, which somewhat restricts its use for load bearing clinical applications. In this study, synthesis and Taguchi grey relational analysis were conducted in the fabrication of mechanically enhanced HAp scaffold for load bearing application. The XRD and FTIR of raw cow bones (RB) and HAp sintered at 900, 1000, and 1100 o C show calcium phosphate contents of the bulk materials. It was also observed that increase in sintering temperature made prominent characteristic peaks of HAp phase to become narrower on the XRD patterns. Taguchi design analysis on the individual hardness and compressive strength revealed 1100 o C as the optimal sintering temperature, but a disparity in compaction load displaying 5 KN for high hardness and 15 K for high compressive strength. Conversely, Taguchi-grey relational analysis gave a common optimal processing parameter levels for high hardness and compressive strength to produce mechanically enhanced HAp scaffold, and are 1100 o C sintering temperature and 5 KN compaction load. Significantly, this study revealed that compaction load has a very high percentage of contribution of 90.15% compared to sintering temperature having a contribution of 7.79%. Confirmation analysis also proved that the experimental grey relational grade of 0.7824 is within 95% confidence interval.

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Optimization of the Synthesis of Hydroxyapatite Powders for Biomedical Applications Using Taguchi's Method

Cited by 5 publications

References 8 publications

Toughening of porous bioceramic scaffolds by bioresorbable polymeric coatings

Toughening of porous bioceramic scaffolds by bioresorbable polymeric coatings

Strengthening of Dense Bioceramic Samples Using Bioresorbable Polymers – A Statistical Approach

Fabrication of mechanically enhanced hydroxyapatite scaffold with the assistance of numerical analysis

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