In the realm of the emergence and spread of infectious diseases with pandemic potential throughout the history, plenty of pandemics (and epidemics), from the plague to AIDS (1981) and SARS (in 2003) to the bunch of COVID variants, have tormented mankind. Though plenty of technological innovations are overwhelmingly progressing to curb them—a significant number of such pandemics astounded the world, impacting billions of lives and posing uncovered challenges to healthcare organizations and clinical pathologists globally. In view of addressing these limitations, a critically exhaustive review is performed to signify the prospective role of technological advancements and highlight the implicit problems associated with rendering best quality lifesaving treatments to the patient community. The proposed review work is conducted in two parts. Part 1 is essentially focused upon discussion of advanced technologies akin to artificial intelligence, Big Data, block chain technology, open-source technology, cloud computing, etc. Research works governing applicability of these technologies in solving many uncovered healthcare issues prominently faced by doctors and surgeons in the fields of cardiology, medicine, neurology, orthopaedics, paediatrics, gynaecology, psychiatry, plastic surgery, etc., as well as their role in curtailing the spread of numerous infectious, pathological, neurotic maladies is thrown light off. Boundary conditions and implicitly associated challenges substantiated by remedies coupled with future directions are presented at the end.