Optimization of Ultrasound-Assisted Extraction of Artemisinin from<i>Artemisia annua</i>L. by Response Surface Methodology

Zhang, Haihui; Zhang, Li; Hu, Xigui; Zhou, Yonghong; Ding, Chunbang; Yang, Ruiwu; Wang, Xiaoli; Li, Dengchao

doi:10.1080/01496395.2013.862545

Cited by 14 publications

(8 citation statements)

References 28 publications

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“…Production of artemisinin in genetically modified microorganisms is an attractive way to enable sufficient supply of the effective antimalarial agent (Zeng et al, 2012). It can be extracted using ultrasound-assisted extraction (UAE) and then detected via HPLC (Widmer et al, 2007;Wang and Liu, 2012;Zhang et al, 2014). The biosynthetic pathway of artemisinin belongs to the isoprenoid pathway and its production pathway was divided in two stages: in the first step Acetyl-CoA make isopentenyl diphosphate (IPP) and its isomer, dimethylallyl diphosphate; in the next step IPP produces artemisinin (Mirzaee et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Exploring Artemisia annua L., artemisinin and its derivatives, from traditional Chinese wonder medicinal science

Shahrajabian

Sun

Cheng

2020

Not Bot Horti Agrobo

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Artemisia annua L. (Chinese wormwood herb, Asteraceae) synthesizes artemisinin, which is known as qinghaosu, considers as a unique sesquiterpene endoperoxide lactone. In traditional Chinese medicine, it has been used for the treatment of fevers and haemorrhoides. More researches on Artemisia annua L. and its derivatives, especially artemisinin and other metabolites will help to increase the knowledge and value of A. annua and its constituents. Phenolics from Artemisia annua consists of coumarins, flavones, flavonols, phenolic acids, and miscellaneous. Artemisinin has attracted much attention from scientists due to its potent antimalarial properties as secondary metabolites. Moreover, more attentions are focusing on the roles of artemisinin and its derivatives in treating obesity and metabolic diseases. They also have anti-bacterial, anti-inflammatory, anti-tumor, anti-protozoa, anti-helminthic, anti-fungal, anti-angiogenic and antiproliferation properties. The most important derivatives of Artemisia annua L. are arteether, artemether, artemiside, artemisinin, artemisone, artesunate, and dihydroartemisinin. Artemisinin also use against some cancers such as liver cancer, brain glioma, leukemia, nasopharyngeal cancer, gallbladder cancer, gastric cancer, cervical cancer, lung cancer, breast cancer and colon cancer. This important gift from ancient Chinese traditional medicine can guarantee health of people all around the world. Further researches should be done on the new advances and development of artemisinin and its derivatives as potential natural medicine in the global fight against so many diseases, malaria included.

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Section: Introductionmentioning

confidence: 99%

Exploring Artemisia annua L., artemisinin and its derivatives, from traditional Chinese wonder medicinal science

Shahrajabian

Sun

Cheng

2020

Not Bot Horti Agrobo

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“…The need is heightened by the fact that the artemisinin level in A. annua is very low, with a concentration of 0.01−1.4%, and the amount of artemisinin currently extracted through conventional methods is only 60− 80%. 7 One potential method to improve the efficiency of artemisinin extraction is utilizing new green solvents. If an extraction solvent has a relatively high extraction efficiency of artemisinin and minimizes the coextraction of impurities, then the extent of purification can be reduced.…”

Section: ■ Introductionmentioning

confidence: 99%

“…The need is heightened by the fact that the artemisinin level in A. annua is very low, with a concentration of 0.01–1.4%, and the amount of artemisinin currently extracted through conventional methods is only 60–80% . One potential method to improve the efficiency of artemisinin extraction is utilizing new green solvents.…”

Section: Introductionmentioning

confidence: 99%

Well-Designed Hydrophobic Deep Eutectic Solvents As Green and Efficient Media for the Extraction of Artemisinin from Artemisia annua Leaves

Cao¹,

Yang²,

Cao³

et al. 2017

ACS Sustainable Chem. Eng.

200

113

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The green and efficient extraction of bioactive compounds from plant biomass is an important area of interest in the pharmaceutical industries. Hydrophilic deep eutectic solvents (DESs) have been considered as green alternatives to conventional solvents for bioactive compound extraction. In this study, we aimed to provide a practical example demonstrating the tunability of hydrophobic DESs as designer solvents to efficiently extract bioactive compounds from plant biomass. Artemisinin, known as the only drug effective in the treatment of malaria, was chosen for extraction from Artemisia annua leaves. A hydrophobic DES named N81Cl-NBA that was tailor-made from methyl trioctyl ammonium chloride and 1-butanol at a molar ratio of 1:4 showed the highest extraction yield. With N81Cl-NBA-based ultrasound-assisted extraction (UAE), the main factors affecting the extraction yield were statistically optimized using a central composite design combined with a response surface methodology. The optimal conditions were obtained as follows: solvent/solid ratio 17.5:1, ultrasonic power 180 W, temperature 45 °C, particle size 80 mesh, and extraction time 70 min. Under these conditions, an extraction yield of 7.9936 ± 0.0364 mg/g was obtained, which was distinctly higher than that obtained using the conventional organic solvent petroleum ether. Moreover, the recovery of the target artemisinin from the N81Cl-NBA extraction solution was achieved by AB-8 macroporous resin with a recovery yield of 85.65%. N81Cl-NBA could be reused at least two times without a significant decrease in extraction yield. This study suggests that not only hydrophilic DESs but also hydrophobic DESs are truly designer solvents that can be used as green and safe extraction solvents for pharmaceutical applications.

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“…with organic solvents is the most commonly applied technology in industry for Ars production, and petroleum ether is reported to be the most suitable solvent for Ars extraction . Besides, several kinds of new solvents (such as hydrofluorocarbons, monoethers, supercritical CO 2 , ionic liquids) − and some techniques for process intensification (including ultrasonic and microwave) ,− have been proposed to enhance Ars production. After extraction of Ars from the leaves, purification steps are needed to obtain Ars with high purity as wax oil with complex compositions could be coextracted from the leaves by the solvents .…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Multilayered Molecularly Imprinted Membrane for Selective Recognition and Separation of Artemisinin

Zhang

Tan

Liu

et al. 2018

ACS Sustainable Chem. Eng.

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Molecularly imprinted membranes with multifunctional layers for artemisinin separation and purification were fabricated on porous chitosan membranes. The molecularly imprinted layer was fabricated through an in situ activator generated by electron transfer–atom transfer radical polymerization method by using artemisinin as the templet molecule. Properties of the prepared materials were characterized by SEM, IR, XPS, EDS, AFM, etc. Adsorption ability and dynamics, permeation capacity, and reusability have been investigated. Results indicate that this kind of molecularly imprinted membrane possesses desirable adsorption ability for artemisinin (18.89 mg/g) and permselectivity factors (β) as high as 2.15 and 2.03 toward artemether and artesunate, respectively. Mechanism of selective adsorption and permeation was unveiled by molecular simulation, which indicates that the tailor-made recognition sites on the membrane possess higher interaction force toward artemisinin than artemether or artesunate, resulting in artemisinin adsorption by the membrane and separation of this drug from its analogues. The method developed here provides an environmental friendly and sustainable technology for separation and purification of natural products.

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Optimization of Ultrasound-Assisted Extraction of Artemisinin fromArtemisia annuaL. by Response Surface Methodology

Cited by 14 publications

References 28 publications

Exploring Artemisia annua L., artemisinin and its derivatives, from traditional Chinese wonder medicinal science

Exploring Artemisia annua L., artemisinin and its derivatives, from traditional Chinese wonder medicinal science

Well-Designed Hydrophobic Deep Eutectic Solvents As Green and Efficient Media for the Extraction of Artemisinin from Artemisia annua Leaves

Fabrication of Multilayered Molecularly Imprinted Membrane for Selective Recognition and Separation of Artemisinin

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