Optimization of uric acid detection with Au nanorod-decorated graphene oxide (GO/AuNR) using response surface methodology

Abstract

Optimization of graphene oxide and Au Nanorod composite and application of GO/AuNR modified electrode for uric acid detection.

New Trends in Uric Acid Electroanalysis

“…Carbon electrodes provide a large potential window [27,28], good conductivity [28,29] and are electrochemically inert [29], which offers stability and versatility for detection techniques. Graphene oxide (GO) [27,28,[30][31][32][33][34][35] and other composites [27,29,32,34,35] can be used for improving the glassy carbon electrode through surface modifications. Graphene oxide has useful electrochemical properties [29], such as hydrophilicity [36], and facile biomolecule adsorption and electron transfer [26,37].…”

“…Gold is the most stable transition metal in electrochemical analysis [55], but its main drawback is the cost. Despite this, recently, a series of gold nanoparticle composite electrodes have been manufactured and tested successfully for detection of uric acid and interferent compounds (Table 2) [27,[29][30][31][32][33][34][35][36]. Because of the high conductivity properties of gold nanoparticle [27,56], this metal is preferred for the configuration of sensors [27].…”

“…Despite this, recently, a series of gold nanoparticle composite electrodes have been manufactured and tested successfully for detection of uric acid and interferent compounds (Table 2) [27,[29][30][31][32][33][34][35][36]. Because of the high conductivity properties of gold nanoparticle [27,56], this metal is preferred for the configuration of sensors [27]. In addition to gold nanoparticles, the most used component for the sensor base are glassy carbon electrodes (GCE) [28].…”

Effect of Aspect Ratio of a Gold-Nanorod-Modified Screen-Printed Carbon Electrode for Carbaryl Detection in Three Different Samples of Vegetables

“…64 One way to control the aspect ratio of the synthesized AuNRs is by varying the added amount of silver nitrate as a specific directing agent into the growth solution of gold nanoparticles to achieve different size dimensions of individual particles of gold nanorods. 65,66 The utilization of gold nanorods and their composites to modify the electrode surface has been reported for the detection of several electroactive molecules such as dopamine, 67,68 glucose, 69 hydrogen peroxide, 70 redox protein, 71−73 dyes, 74,75 and bacteria. 76,77 However, to the best of our knowledge, we here describe the first systematic investigation of an electrochemical sensor based on three different aspect ratios of gold nanorods modified on commercial SPCE for carbaryl detection.…”

“…In addition, the presence of AuNRs on the surface of SPCE could improve the sensitivity of the electrochemical sensor by adjusting the aspect ratio (length/diameter) of nanorods during the synthesis of gold nanoparticles . One way to control the aspect ratio of the synthesized AuNRs is by varying the added amount of silver nitrate as a specific directing agent into the growth solution of gold nanoparticles to achieve different size dimensions of individual particles of gold nanorods. , The utilization of gold nanorods and their composites to modify the electrode surface has been reported for the detection of several electroactive molecules such as dopamine, , glucose, hydrogen peroxide, redox protein, − dyes, , and bacteria. , …”