Optimization of α-tocopherol loaded solid lipid nanoparticles by central composite design

Carvalho, Sabrina Matos de; Noronha, Carolina Montanheiro; Floriani, Caroline Louise; Lino, Renata Calegari; Rocha, Gabriela; Bellettini, Ismael C.; Ogliari, Paulo José; Barreto, Pedro Luiz Manique

doi:10.1016/j.indcrop.2013.04.054

Cited by 88 publications

(51 citation statements)

References 39 publications

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“…Encapsulation efficiency (EE). Encapsulation efficiency was defined as the difference between the content of the free active compound (unencapsulated) and the content entrapped in the polymer matrix (encapsulated), according to methodology by [7]. Free thymol and carvacrol were obtained by membrane separation method using Amicon Ultra Centrifugal Filters with an Ultracel 30k membrane (Millipore, Ireland).…”

Section: Stability Studiesmentioning

confidence: 99%

“…The above may be due to the samples preparation process for TEM analyses, such as the removal of the solvent. This may cause changes that may affect the nanoparticlesí form and size [7]. The difference may also be attributed to the flattening of the particles on the grid and to the small number of particles registered by TEM when compared to those by light scattering techniques.…”

Section: Analysis By Transmission Electron Microscopy (Tem)mentioning

confidence: 99%

See 1 more Smart Citation

Characterization and evaluation of physicochemical and antimicrobial properties of zein nanoparticles loaded with phenolics monoterpenes

Rosa

Maciel

Carvalho

et al. 2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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111

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Section: Stability Studiesmentioning

confidence: 99%

Section: Analysis By Transmission Electron Microscopy (Tem)mentioning

confidence: 99%

Characterization and evaluation of physicochemical and antimicrobial properties of zein nanoparticles loaded with phenolics monoterpenes

Rosa

Maciel

Carvalho

et al. 2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

Self Cite

111

View full text Add to dashboard Cite

“…They also have the potential to protect chemically labile active compounds against degradation [6,7]. In cosmetics, these properties make them a viable replacement of traditional formulations, and thus, they have been studied as encapsulation systems for various labile compounds, including sunscreen agents [8][9][10][11] and antioxidants [12,13].…”

Section: Introductionmentioning

confidence: 99%

Photostability enhancement by encapsulation of α-tocopherol into lipid-based nanoparticles loaded with a UV filter

Niculae

Lăcătuşu

Bors

et al. 2014

Comptes Rendus. Chimie

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“…Carvalho et al . obtained SLNs with comparable zeta potential (−41.9 mV) and demonstrated 3 weeks of stability at 6 or 20°C. Two similar samples of nanoparticles with different zeta potential were prepared by Abla and Banga , and the ones having lowest zeta potential (−10 mV) were unstable.…”

Section: Characterization Of Slns/nlcs Loaded With Vitamin Ementioning

confidence: 91%

Lipid nanoparticles (SLN & NLC) for delivery of vitamin E: a comprehensive review

Sáez

Souza

Mansur

2018

Intern J of Cosmetic Sci

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The antioxidative and photoprotective properties of vitamin E have caused it to be included as an active agent in various pharmaceutical and cosmetic products. However, its lipophilicity, chemical instability and poor skin penetration have limited the effectiveness of these formulations. For that reason, many attempts to include it in different drug delivery systems have been made. In recent decades, lipid nanoparticles have received special attention due to their advantages of compatibility with the skin, ability to enhance penetration of drugs in the stratum corneum, protection of the encapsulated substance against degradation induced by the external medium and control of drug release. This work reviews the current status of the encapsulation of vitamin E in lipid nanoparticles. We describe the most important methods for obtaining and characterizing lipid nanoparticles containing vitamin E (LNP-VE), various techniques for the evaluation of vitamin E's properties after encapsulation, the main in vitro and in vivo studies of the potential effectiveness or toxicity of LNP-VE, the formulations and stability studies of this delivery system, the commercial products based on LNP-VE and the regulatory aspects related to lipid nanoparticles. Finally, we discuss the most relevant advantages of encapsulating vitamin E in such particles and critical aspects that still demand attention to enhance the potential of solid lipid nanoparticles to deliver vitamin E.

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Optimization of α-tocopherol loaded solid lipid nanoparticles by central composite design

Cited by 88 publications

References 39 publications

Characterization and evaluation of physicochemical and antimicrobial properties of zein nanoparticles loaded with phenolics monoterpenes

Characterization and evaluation of physicochemical and antimicrobial properties of zein nanoparticles loaded with phenolics monoterpenes

Photostability enhancement by encapsulation of α-tocopherol into lipid-based nanoparticles loaded with a UV filter

Lipid nanoparticles (SLN & NLC) for delivery of vitamin E: a comprehensive review

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