Optimized and validated spectrophotometric methods for the determination of amiodarone hydrochloride in commercial dosage forms using N-bromosuccinimide and bromothymol blue

Rahman, Nafisur; Haque, Sk Manirul; Azmi, Syed Najmul Hejaz; Rahman, Habibur

doi:10.1016/j.jscs.2013.09.001

Cited by 25 publications

(15 citation statements)

References 19 publications

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“…Preliminary investigations have been shown that Lisinopril react with Alizarin in buffer Britton solution 0.1M at pH=8.0 in presence catalytic reagent as ferric chloride 0.40 ml with Concentration (1 × 10 -3 M) to give red coloured complex which absorbs at λ max =434 nm as shown in Figure 1 [30,35].…”

Section: Resultsmentioning

confidence: 99%

“…Commercial formulation was successfully analyzed for the lisinopril by the proposed method and the results are compared with reference method (20) (Table 3) did not exceed the theoretical values, which indicates the absence of any difference between the methods compared. The proposed method gives good results for lisinopril in pure and pharmaceutical formulations [35,36]. …”

Section: Stoichiometric Relationshipmentioning

confidence: 95%

“…Beer's law was obeyed in the range of 4.415-300.23 µg/ml. More than 99% recover of Lisinopril was obtained in the presence of possible excipients and ingredient in lisinopril formulations (Tables 1 and 2) [35].…”

Section: Stoichiometric Relationshipmentioning

confidence: 99%

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New Method for Spectrophotometric Determination of Lisinopril in Pure Form and in Pharmaceutical Formulations

Shraitah¹,

Okdeh²

2016

Mod Chem Appl

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An accurate, simple, fast and cheap spectrophotometric method has been developed for the determination of lisinopril in pharmaceutical pure and dosage forms. The method is based on the reaction of Alizarin with primary amine present in the lisinopril in the presence of 80% ethyl alcohol. This reaction produces a complex Red colored product which absorbs maximally at 434 nm. Beer's law was obeyed in the range of 4.415-300.23 µg/mL with molar absorptivity of 1.619 × 10 3 L mole -1 cm -1 Sandell's sensitivity 0.272 µg.cm -2 . The effects of variables such as temperature, heating time, concentration of color producing reagent, and stability of color were investigated to optimize the procedure. The results are validated statistically. The proposed method was applied to commercially available tablets, and the results were Pharmaceutical formulations..

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Section: Resultsmentioning

confidence: 99%

Section: Stoichiometric Relationshipmentioning

confidence: 95%

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New Method for Spectrophotometric Determination of Lisinopril in Pure Form and in Pharmaceutical Formulations

Shraitah¹,

Okdeh²

2016

Mod Chem Appl

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“…It has a strong brominating ability [27]. It has been reported that tertiary amine reacts with N-bromosuccinimide to produce colored intermediate, which on hydrolysis gives aldehydes and brominated secondary amine whereas N-bromosuccinimide is irreversibly reduced to succinimide [28].…”

Section: Methods IImentioning

confidence: 99%

Two spectrophotometric methods for the determination of azithromycin and roxithromycin in pharmaceutical preparations

2017

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Two new and simple spectrophotometric procedures have been proposed and validated for estimation of two important macrolide antibiotics namely, azithromycin dihydrate and roxithromycin. Method I depends on complex formation between any of the two drugs and copper in acidic medium where the absorbances of the produced complexes are measured at 250 and 264 nm with linearity ranges of 1.0-100.0 and 2.0-130.0 µg/mL for the two drugs, respectively. Method II depends on the reaction of these drugs with N-bromosuccinimide forming a product which is yellow colored, measured at 264 and 278 nm, with linearity ranges of 2.0-140.0 and 3.0-160.0 µg/mL for azithromycin dihydrate and roxithromycin, respectively. The proposed methods were subjected to detailed validation procedure; moreover they were used for the estimation of the concerned drugs in their different dosage forms. Study of the reactions stoichiometry was carried out; furthermore, a reaction mechanism proposal was presented.

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“…Various analytical procedures were found in the literature for the determination of LNP using titrimetric (Basavaiah et al, 2010), visible spectrophotometric (Rahman et al, 2007;El-Yazbi et al, 1999;Rahman et al, 2005;El-Gindy et al, 2001;Paraskevas et al, 2002;Nafisur et al, 2005;Asad et al, 2005;Rajasekaran, and Udayavani, 2001;Basavaiah et al, 2009;Razak et al, 2003), derivative UV absorption spectrophotometric (El-Yazbi et al, 1999;Bonazzi et al, 1997a, b;Durisehvar and Hulya, 1999;Beata, 2005;Erk, 1998;Prasad et al, 1999;Jain and Agrawal, 2000;Mashru and Parikh, 2000), high-performance liquid chromatographic (HPLC) (The US Pharmacopoeia, 2000;Ivanoic et al, 2007;Nevin and Murat, 1999;Sane et al 1992;Bonazzi et al, 1997a, b;El-Gindy et al, 2001;Christopher et al, 2004), highperformance thin layer chromatographic (HPTLC) (Pandya et al, 2017), gas chromatographic (Avadhanulu and Pantulu, 1993), capillary electrophoretic (Qin et al, 1993;Gotti et al 2000), spectrofluorimetric (El-Gindy et al, 2001;Esra et al, 2003;Zacharis et al 2004), and polarographic (Razak et al 2003;El-Enany, Belal, and Al-Ghannam, 2003;…”

Section: Introductionmentioning

confidence: 99%

Development of membrane electrodes for selective determination of lisinopril in pharmaceuticals

Rajendraprasad

Basavaiah

2019

J Anal Sci Technol

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Background: Lisinopril (LNP) is an angiotensin-converting enzyme inhibitor used as anti-hypertensive, cardiovascular, in anti-prophylactic and anti-diabetic nephropathy drug. Development of two new, simple, low cost, and selective membrane-based ion-selective electrodes has been proposed for the determination of LNP in pharmaceuticals. Methods: The electrodes are based on poly(vinyl)chloride membrane doped with LNP-phosphotungstic acid (LNP-PTA) and LNP-phosphomolybdic acid (LNP-PMA) ion-pairs as molecular recognition materials. Results: The developed LNP-PTA and LNP-PMA electrodes are applicable for the determination of LNP over the linear range of 5 × 10 −5 -2.4 × 10 −3 mol l −1 . The working pH ranges to measure potentials were 2.5 to 6.4 and 2.3 to 6.0 for LNP-PTA and LNP-PMA ISEs, respectively. The electrodes displayed the rapid Nernstian responses as revealed by the values of slopes 55.06 and 52.39 mV/decade, with limit of detection (LOD) values of 1.2 × 10 −5 and 1.18 × 10 −5 mol l −1 for LNP-PTA and LNP-PMA electrodes, respectively. The limits of quantitation (LOQ) values have also been calculated for both the electrodes. The developed electrodes have potential stability for up to 1 month and emerged as highly selective for the determination of LNP over other spiked ions and compounds. Conclusions: The proposed electrodes have been validated and found that they are suitable for the determination of LNP in pharmaceuticals in pure form and in dosage forms. The results obtained in the analysis of LNP using proposed electrodes have been compared statistically with reference method's results to assess the accuracy and precision. Robustness and ruggedness of the developed electrodes have also been checked and found satisfactory. The recovery studies have been performed by standard addition procedure to assess the role of excipients in tablets containing LNP and the results obtained are satisfactory.

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Optimized and validated spectrophotometric methods for the determination of amiodarone hydrochloride in commercial dosage forms using N-bromosuccinimide and bromothymol blue

Cited by 25 publications

References 19 publications

New Method for Spectrophotometric Determination of Lisinopril in Pure Form and in Pharmaceutical Formulations

New Method for Spectrophotometric Determination of Lisinopril in Pure Form and in Pharmaceutical Formulations

Two spectrophotometric methods for the determination of azithromycin and roxithromycin in pharmaceutical preparations

Development of membrane electrodes for selective determination of lisinopril in pharmaceuticals

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