Optimized EDXRF system for simultaneous detection of gold and silver nanoparticles in tumor phantom

Santibáñez, M.; Saavedra, R.; Vedelago, José; Malano, Francisco; Valente, M.

doi:10.1016/j.radphyschem.2019.108415

Cited by 11 publications

(5 citation statements)

References 25 publications

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“…In contrast to alternative methods like inductively coupled plasma mass spectrometry (ICP-MS), XRF is non-destructive (neglecting the radiation damage) and does only require minimal sample preparation. In combination with the advance in the field of nanoparticles in recent years, XRF is a promising tool for preclinical cell tracking, nanoparticle uptake or drug delivery studies 1 – 8 . In particular, it enables cell uptake measurements of medium and high-Z elements down to the pg/cell level 3 , 4 , 9 .…”

Section: Introductionmentioning

confidence: 99%

In-situ x-ray fluorescence imaging of the endogenous iodine distribution in murine thyroids

Körnig

Staufer

Schmutzler

et al. 2022

Sci Rep

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X-ray fluorescence imaging (XFI) is a non-invasive detection method of small quantities of elements, which can be excited to emit fluorescence x-ray photons upon irradiation with an incident x-ray beam. In particular, it can be used to measure nanoparticle uptake in cells and tissue, thus making it a versatile medical imaging modality. However, due to substantially increased multiple Compton scattering background in the measured x-ray spectra, its sensitivity severely decreases for thicker objects, so far limiting its applicability for tracking very small quantities under in-vivo conditions. Reducing the detection limit would enable the ability to track labeled cells, promising new insights into immune response and pharmacokinetics. We present a synchrotron-based approach for reducing the minimal detectable marker concentration by demonstrating the feasibility of XFI for measuring the yet inaccessible distribution of the endogenous iodine in murine thyroids under in-vivo conform conditions. This result can be used as a reference case for the design of future preclinical XFI applications as mentioned above.

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Section: Introductionmentioning

confidence: 99%

In-situ x-ray fluorescence imaging of the endogenous iodine distribution in murine thyroids

Körnig

Staufer

Schmutzler

et al. 2022

Sci Rep

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“…It is widely known that high-atomic-number nanoparticle infusion within biological tissue presents multiple benefits in diagnostic and therapeutic terms, as is the case for teletherapy and brachytherapy [ 1 , 2 , 3 , 4 ]. This is due to the localized deposition of energy by photoelectrons and Auger electrons produced by photoelectric interaction augmentation between primary radiation and the high-Z nanoparticle infused into the tissue.…”

Section: Introductionmentioning

confidence: 99%

An Optimized Method for Evaluating the Potential Gd-Nanoparticle Dose Enhancement Produced by Electronic Brachytherapy

Fuentealba,

Ferreira,

Salgado

et al. 2024

Nanomaterials

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This work reports an optimized method to experimentally quantify the Gd-nanoparticle dose enhancement generated by electronic brachytherapy. The dose enhancement was evaluated considering energy beams of 50 kVp and 70 kVp, determining the Gd-nanoparticle concentration ranges that would optimize the process for each energy. The evaluation was performed using delaminated radiochromic films and a Poly(methyl methacrylate) (PMMA) phantom covered on one side by a thin 2.5 μm Mylar filter acting as an interface between the region with Gd suspension and the radiosensitive film substrate. The results for the 70 kVp beam quality showed dose increments of 6±6%, 22±7%, and 9±7% at different concentrations of 10, 20, and 30 mg/mL, respectively, verifying the competitive mechanisms of enhancement and attenuation. For the 50 kVp beam quality, no increase in dose was recorded for the concentrations studied, indicating that the major contribution to enhancement is from the K-edge interaction. In order to separate the contributions of attenuation and enhancement to the total dose, measurements were replicated with a 12 μm Mylar filter, obtaining a dose enhancement attributable to the K-edge of 29±7% and 34±7% at 20 and 30 mg/mL, respectively, evidencing a significant additional dose proportional to the Gd concentration.

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“…Most existing metal sensors are based on the chemical and optical properties of metal substances [1][2][3][4][5][6][7][8][9][10][11][12], concentrating on the reaction between the substance atoms and catalysts [1,3,7], or light excitation [8][9][10][11][12]. Electroreduction from acids (AuCl 4 and [PdCl 4 ] 2 ) was used for recovering gold (Au) and palladium (Pd) [1].…”

Section: Introductionmentioning

confidence: 99%

“…Electroreduction from acids (AuCl 4 and [PdCl 4 ] 2 ) was used for recovering gold (Au) and palladium (Pd) [1]. Silver (Ag) and Au were detected using PH-sensitivity [2] and aminoantipyrine solid [3] by Xray fluorescent system [7]. Surface plasmon, the collective charge oscillations, that occur at the interface between conductors and environment, are mainly used in optical metal sensors.…”

Section: Introductionmentioning

confidence: 99%

Metal Discovery by Highly Sensitive Microwave Multi-Band Metamaterial-Inspired Sensors

Al-Duhni¹,

Wongkasem²

2021

PIER B

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A simple, compact, contactless, and high sensitivity metamaterial-inspired sensor has been developed to detect and classify precious transition metals in the S-and C-band regime, using reflection coefficients. A multi-band metamaterial, quadruple concentric circular split ring resonator, is specifically designed as a sensing enhancer, where the additional bands can effectively trigger the electromagnetic properties, as well as enhance the differentiation between the testing metal samples. The proposed sensor was tested on precious transition metals, silver, platinum, and gold thin slabs of various thicknesses, from 0.5 µm to 3 mm. Five resonances were established in the frequency range of 2-8 GHz. Distinguishable frequency responses generated from different metal samples at those five resonances specify the capability of classifying the metal contents and thicknesses.

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Optimized EDXRF system for simultaneous detection of gold and silver nanoparticles in tumor phantom

Cited by 11 publications

References 25 publications

In-situ x-ray fluorescence imaging of the endogenous iodine distribution in murine thyroids

In-situ x-ray fluorescence imaging of the endogenous iodine distribution in murine thyroids

An Optimized Method for Evaluating the Potential Gd-Nanoparticle Dose Enhancement Produced by Electronic Brachytherapy

Metal Discovery by Highly Sensitive Microwave Multi-Band Metamaterial-Inspired Sensors

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