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SUMMARY:Abnormal interaction between oral epithelium and underlying mesenchematic tissue during odontogenesis could result in teeth with an anatomical variation. First maxilar premolar has such variable root canal morphology. However, (0.2-6% of cases) a three-rooted premolar is particularly uncommon. First mandibular premolar frequently has one root and one single canal (75% of cases), however, a tooth with two canals and two separate roots could be found (19.5-22.5%). Execution of an accurate diagnosis of root canal system is essential to perform a successful endodontic treatment and tooth rehabilitation. This article describes diagnosis, endodontic treatment and rehabilitation (means single crown) of a maxillary three-rooted and three-canal first premolar, and a non-endodontically treated mandibular first premolar with two canals and two independent roots in a single patient.

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