Optimized Microemulsions and Solid microemulsion Systems of Simvastatin: Characterization and In Vivo Evaluation

Dixit, Rahul; Nagarsenker, Mangal S.

doi:10.1002/jps.22208

Cited by 13 publications

(6 citation statements)

References 36 publications

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“…Therefore, the 1:20 surfactant-to-pesticide ratio was determined for the preparation of the solid nanodispersions. The optimized surfactant content was much lower than that in most microemulsions and solid microemulsions [ 34 – 38 ].…”

Section: Resultsmentioning

confidence: 99%

Stability and Biological Activity Evaluation of Chlorantraniliprole Solid Nanodispersions Prepared by High Pressure Homogenization

et al. 2016

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Poorly water-soluble compounds are difficult to develop as pesticide products and face great challenges in water-based and environmentally friendly formulation development. In this study, high pressure homogenization combined with lyophilization was adopted to prepare the solid nanodispersions of chlorantraniliprole with poor solubility and high melting point. The mean particle sizes of the solid nanodispersions with different pesticide contents were all less than 75 nm, even when the content was up to 91.5%. For the 2.5% chlorantraniliprole solid nanodispersion with the mean particle size of 29 nm, the suspensibility and wetting time in water were 97.32% and 13 s, respectively. The re-dispersibility and wettability were superior to those of conventional water dispersible granules. The retention on the rice leaf of 18.7 mg/cm2 was 1.5 and 3 times that of commercial aqueous suspension concentrate and pure water. The bioassay result to diamondback moths indicated that the toxicity of the solid nanodispersion was 3.3 and 2.8 times that of technical and aqueous suspension concentrate, respectively. Moreover, the solid nanodispersion has the advantages of total avoidance of organic solvents, significant reduction of surfactants and feasibility of obtaining high concentration nanoformulations. The solid nanodispersion is an attractive candidate for improving pesticide solubility and efficacy, and its application in crop production will reduce both residues in food and environmental pollution of pesticide.

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Section: Resultsmentioning

confidence: 99%

Stability and Biological Activity Evaluation of Chlorantraniliprole Solid Nanodispersions Prepared by High Pressure Homogenization

et al. 2016

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“…One popular technique for LBF solidification is the adsorption of the LBF directly onto high‐surface‐area adsorbents such as Aerosil®, Hubersorb®, Sylysia®, and Neusilin® . Neusilin® US2, a magnesium alumino metasilicate in granular form, has been most widely investigated for this application, as it has a high absorbent capacity for liquid substances, and good flowability and tabletability .…”

Section: Introductionmentioning

confidence: 99%

“…One popular technique for LBF solidification is the adsorption of the LBF directly onto high-surface-area adsorbents such as Aerosil R , Hubersorb R , Sylysia R , and Neusilin R . [13][14][15] Neusilin R US2, a magnesium alumino metasilicate in granular form, has been most widely investigated for this application, as it has a high absorbent capacity for liquid substances, 13,[15][16][17] and good flowability 13 and tabletability. 17 However, despite the attractiveness of this approach, we have previously shown using two exemplar self-emulsifying drug delivery systems (SEDDS) that in vitro and in vivo performance can be reduced when compared with the equivalent liquid SEDDS.…”

Section: Introductionmentioning

confidence: 99%

Lipid-Based Formulations Solidified Via Adsorption onto the Mesoporous Carrier Neusilin® US2: Effect of Drug Type and Formulation Composition on In Vitro Pharmaceutical Performance

Williams

Speybroeck

Augustijns

et al. 2014

Journal of Pharmaceutical Sciences

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“…Having high surface area and commonly being porous, silicates are capable of adsorbing liquids, often as much as 2 to 3 times their own weights. They were first utilized by Jarowski et al (9) for adsorbing organic solutions of poorly water-soluble drugs, and, in more recent years, they were investigated for adsorbing self-emulsifying drug delivery systems to convert them into dry powders (10–14). However, such a formulation approach often led to the development of powder-filled hard gelatin capsule formulations as the silicates were inherently non-compactible or the loading of liquids prevented their compression into tablets (15).…”

Section: Introductionmentioning

confidence: 99%

Development of Solid SEDDS, IV: Effect of Adsorbed Lipid and Surfactant on Tableting Properties and Surface Structures of Different Silicates

Gumaste

Pawlak

Dalrymple³

et al. 2013

Pharm Res

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PurposeTo compare six commonly available silicates for their suitability to develop tablets by adsorbing components of liquid lipid-based drug delivery systems.MethodsThe tabletability of Aerosil® 200, Sipernat® 22, Sylysia® 350, Zeopharm® 600, Neusilin® US2 and Neusilin® UFL2 were studied by compressing each silicate into tablets in the presence of 20% microcrystalline cellulose and measuring the tensile strength of tablets produced. Three components of lipid based formulations, namely, Capmul® MCM EP (glycerol monocaprylocaprate), Captex® 355 EP/NF (caprylic/capric triglycerides) and Cremophor® EL (PEG-35 castor oil), were adsorbed individually onto the silicates at 1:1 w/w, and the mixtures were then compressed into tablets. The SEM photomicrographs of neat silicates and their 1:1 w/w mixtures (also 1:2 and 1:3 for Neusilin® US2 and Neusilin® UFL2) with one of the liquids (Cremophor® EL) were recorded.ResultsNeat Aerosil® 200, Sipernat® 22 and Sylysia® 350 were non-tabletable to the minimum acceptable tensile strength of 1 MPa, and they were also non-tabletable in presence of liquid. While Zeopharm® 600, Neusilin® US2 and Neusilin® UFL2 were tabletable without the addition of liquids, only Neusilin® US2 retained acceptable tabletability with 1:1 liquid. The SEM images of silicate-liquid mixtures indicated that, except for Neusilin® US2, much of the adsorbed liquid distributed primarily at the surface of particles rather than inside pores, which hindered their compaction into tablets.ConclusionAmong the six silicates studied, Neusilin® US2 was the only silicate able to produce tablets with acceptable tensile strength in presence of a lipid component at 1:1 w/w ratio due to the fact that the liquid was mostly adsorbed into the pores of the silicate rather than at the surface.

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Optimized Microemulsions and Solid microemulsion Systems of Simvastatin: Characterization and In Vivo Evaluation

Cited by 13 publications

References 36 publications

Stability and Biological Activity Evaluation of Chlorantraniliprole Solid Nanodispersions Prepared by High Pressure Homogenization

Stability and Biological Activity Evaluation of Chlorantraniliprole Solid Nanodispersions Prepared by High Pressure Homogenization

Lipid-Based Formulations Solidified Via Adsorption onto the Mesoporous Carrier Neusilin® US2: Effect of Drug Type and Formulation Composition on In Vitro Pharmaceutical Performance

Development of Solid SEDDS, IV: Effect of Adsorbed Lipid and Surfactant on Tableting Properties and Surface Structures of Different Silicates

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