Optimized phospholipid-based nanoparticles for inner ear drug delivery and therapy

Yang, Keum‐Jin; Son, Jihwan; Jung, So Young; Yi, Gawon; Yoo, Jin‐Hong; Kim, Dong-Kee; Koo, Heebeom

doi:10.1016/j.biomaterials.2018.04.038

Cited by 67 publications

(48 citation statements)

References 26 publications

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“…Moreover, the drug will accumulate in cochlea at only a low concentration; therefore, many methods are currently being investigated to improve the permeability of the RWM for local drug delivery. Some efficient carriers such as poly (lactic-co-glycolic acid) nanoparticles and phospholipid-based nanoparticles are used as inner ear nanoparticulate carriers to produce better therapeutic effects and to maintain long-term particle circulation in the perilymph (4,5).…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-induced microbubble cavitation via a transcanal or transcranial approach facilitates inner ear drug delivery

Liao¹,

Wang²,

Weng³

et al. 2020

JCI Insight

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Section: Introductionmentioning

confidence: 99%

Ultrasound-induced microbubble cavitation via a transcanal or transcranial approach facilitates inner ear drug delivery

Liao¹,

Wang²,

Weng³

et al. 2020

JCI Insight

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“…Phospholipid‐based nanoparticles are of particular interest because their bilayer structure enables them to encapsulate and transport both hydrophobic and hydrophilic molecules across the RWM . Dexamethasone encapsulated in four types of phospholipid‐based nanoparticles—neutral, anionic, cationic, and cationic‐PEG—have been tested in a mouse model of ototoxicity induced by kanamycin and furosemide . Although all four types of nanoparticles with encapsulated dexamethasone were superior to pure dexamethasone sodium phosphate solution in recovering hearing in a mouse model of ototoxicity, cationic‐PEG nanoparticles obtained the best therapeutic results.…”

Section: Recent Advances In Inner Ear Deliverymentioning

confidence: 99%

Inner ear delivery: Challenges and opportunities

Szeto

Chiang

Valentini

et al. 2019

Laryngoscope Investig Oto

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Objectives The treatment of inner ear disorders remains challenging due to anatomic barriers intrinsic to the bony labyrinth. The purpose of this review is to highlight recent advances and strategies for overcoming these barriers and to discuss promising future avenues for investigation. Data Sources The databases used were PubMed, EMBASE, and Web of Science. Results Although some studies aimed to improve systemic delivery using nanoparticle systems, the majority enhanced local delivery using hydrogels, nanoparticles, and microneedles. Developments in direct intracochlear delivery include intracochlear injection and intracochlear implants. Conclusions In the absence of a systemic drug that targets only the inner ear, the best alternative is local delivery that harnesses a combination of new strategies to overcome anatomic barriers. The combination of microneedle technology with hydrogel and nanoparticle delivery is a promising area for future investigation. Level of Evidence NA

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“…A similar investigation using artificial mouse penetration as the first barrier showed that almost neutral or PEGylated NPs exhibited higher rates of intracellular delivery compared with the other groups, indicating the determinant role of a neutral charge in tackling two structural barriers, namely, epithelial layers and the cellular membrane ( Figure 3 ). 34 …”

Section: Delivery Systems For Hearing Disordersmentioning

confidence: 99%

“…The Deaf-Cat-PEG-Dex group exhibited significantly better hearing at all frequencies tested than the Deaf-DexP and Deaf-saline control groups (#, p = 0.05, n = 6). Adopted from Yang et al 34 …”

Section: Delivery Systems For Hearing Disordersmentioning

confidence: 99%

Auditory disorders and future therapies with delivery systems

Lee

Lim

et al. 2018

J Tissue Eng

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Auditory function takes a major part in human life. While sensorineural hearing loss is related with many factors including genetic disorders, age and noise, the clear causes are not well understood. Even more, the currently available treatments with drugs cause side effects, which thus are considered suboptimal. Here, we communicate the delivery systems with biomaterials that can be possible therapeutic options to restore hearing and vestibular functions. We introduce briefly the various pathological factors related with hearing loss and the limitation of current therapies, detail the recent studies on delivery systems including nanoparticles and hydrogels and discuss future clinical availability.

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Optimized phospholipid-based nanoparticles for inner ear drug delivery and therapy

Cited by 67 publications

References 26 publications

Ultrasound-induced microbubble cavitation via a transcanal or transcranial approach facilitates inner ear drug delivery

Ultrasound-induced microbubble cavitation via a transcanal or transcranial approach facilitates inner ear drug delivery

Inner ear delivery: Challenges and opportunities

Auditory disorders and future therapies with delivery systems

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