Optimized time‐resolved imaging of contrast kinetics (TRICKS) in dynamic contrast‐enhanced MRI after peptide receptor radionuclide therapy in small animal tumor models
Abstract:Anti-tumor efficacy of targeted peptide-receptor radionuclide therapy (PRRT) relies on several factors, including functional tumor vasculature. Little is known about the effect of PRRT on tumor vasculature. With dynamic contrast-enhanced (DCE-) MRI, functional vasculature is imaged and quantified using contrast agents. In small animals DCE-MRI is a challenging application. We optimized a clinical sequence for fast hemodynamic acquisitions, time-resolved imaging of contrast kinetics (TRICKS), to obtain DCE-MRI … Show more
“…Two clinical contrast-enhanced MRI sequences, three-dimensional time-resolved imaging of contrast kinetics (3D-TRICKS) and three-dimensional BRAin VOlume T 1 imaging (3D BRAVO), were adopt for showing the anatomy of swine vessels and tissues. Specifically, 3D-TRIKES is a clinical sequence for fast hemodynamic acquisitions, which is expected to obtain DCE-MR images at both high-spatial and high temporal resolution in swine 56 ; 3D BRAVO is a clinical fast T 1 -weighted 3D gradient-echo (GRE) sequences, which has been commonly used for high-spatial-resolution human cerebrovascular and brain diseases imaging 57 . Fig.…”
Magnetic resonance (MR) angiography is one of the main diagnostic approaches for cardiac-cerebral vascular diseases. Nevertheless, the non-contrast-enhanced MR angiography suffers from its intrinsic problems derived from the blood flow-dependency, while the clinical Gd-chelating contrast agents are limited by their rapid vascular extravasation. Herein, we report a hypersensitive MR angiography strategy based on interlocking stratagem of zwitterionic Gd-chelate contrast agents (PAA-Gd). The longitudinal molar relaxivity of PAA-Gd was 4.6-times higher than that of individual Gd-chelates as well as appropriate blood half-life (73.8 min) and low immunogenicity, enabling sophisticated micro-vessels angiography with a resolution at the order of hundred micrometers. A series of animal models of cardiac-cerebrovascular diseases have been built for imaging studies on a 7.0 T MRI scanner, while the clinical translation potential of PAA-Gd has been evaluated on swine on a 3.0 T clinical MRI scanner. The current studies offer a promising strategy for precise diagnosis of vascular diseases.
“…Two clinical contrast-enhanced MRI sequences, three-dimensional time-resolved imaging of contrast kinetics (3D-TRICKS) and three-dimensional BRAin VOlume T 1 imaging (3D BRAVO), were adopt for showing the anatomy of swine vessels and tissues. Specifically, 3D-TRIKES is a clinical sequence for fast hemodynamic acquisitions, which is expected to obtain DCE-MR images at both high-spatial and high temporal resolution in swine 56 ; 3D BRAVO is a clinical fast T 1 -weighted 3D gradient-echo (GRE) sequences, which has been commonly used for high-spatial-resolution human cerebrovascular and brain diseases imaging 57 . Fig.…”
Magnetic resonance (MR) angiography is one of the main diagnostic approaches for cardiac-cerebral vascular diseases. Nevertheless, the non-contrast-enhanced MR angiography suffers from its intrinsic problems derived from the blood flow-dependency, while the clinical Gd-chelating contrast agents are limited by their rapid vascular extravasation. Herein, we report a hypersensitive MR angiography strategy based on interlocking stratagem of zwitterionic Gd-chelate contrast agents (PAA-Gd). The longitudinal molar relaxivity of PAA-Gd was 4.6-times higher than that of individual Gd-chelates as well as appropriate blood half-life (73.8 min) and low immunogenicity, enabling sophisticated micro-vessels angiography with a resolution at the order of hundred micrometers. A series of animal models of cardiac-cerebrovascular diseases have been built for imaging studies on a 7.0 T MRI scanner, while the clinical translation potential of PAA-Gd has been evaluated on swine on a 3.0 T clinical MRI scanner. The current studies offer a promising strategy for precise diagnosis of vascular diseases.
“…Thirdly, the view-ordering used in this study could smooth the temporal information, especially during the injection period. However, this is not considered to be a significant effect and other studies have used similar analysis for various DCE applications, including breast [ 38 , 39 ], prostate [ 40 ] and also animal models [ 41 ]. The last limitation is that a thick coronal imaging slice (1.4 mm) was used in this study.…”
ObjectiveThis study aims to explore the relationship between plaque surface morphology and neovascularization using a high temporal and spatial resolution 4D contrast-enhanced MRI/MRA sequence.Materials and methodsTwenty one patients with either recent symptoms or a carotid artery stenosis ≥40% were recruited in this study. Plaque surface morphology and luminal stenosis were determined from the arterial phase MRA images. Carotid neovascularization was evaluated by a previously validated pharmacokinetic (PK) modeling approach. K
trans (transfer constant) and v
p (partial plasma volume) were calculated in both the adventitia and plaque.ResultsImage acquisition and analysis was successfully performed in 28 arteries. Mean luminal stenosis was 44% (range 11–82%). Both adventitial and plaque K
trans in ulcerated/irregular plaques were significantly higher than smooth plaques (0.079 ± 0.018 vs. 0.064 ± 0.011 min−1, p = 0.02; 0.065 ± 0.013 vs. 0.055 ± 0.010 min−1, p = 0.03, respectively). Positive correlations between adventitial K
trans and v
p against stenosis were observed (r = 0.44, p = 0.02; r = 0.55, p = 0.01, respectively).ConclusionThis study demonstrates the feasibility of using a single sequence to acquire both high resolution 4D CE-MRA and DCE-MRI to evaluate both plaque surface morphology and function. The results demonstrate significant relationships between lumen surface morphology and neovascularization.
“…These new therapies require novel tools and potential targeting imaging to assess the response to treatment [ 140 , 141 ]. Pseudoprogression, tumor growth from treatment effect rather than true disease progression, has been described with immune checkpoint inhibitors.…”
Section: Cancer Cell Signaling Pathways – Figmentioning
Molecular imaging continues to influence every aspect of cancer care including detection, diagnosis, staging and therapy response assessment. Recent advances in the understanding of cancer biology have prompted the introduction of new targeted therapy approaches. Precision medicine in oncology has led to rapid advances and novel approaches optimizing the use of imaging modalities in cancer care, research and development. This article focuses on the concept of targeted therapy in cancer and the challenges that exist for molecular imaging in cancer care.
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