Optimizing antibiotic therapies to reduce the risk of bacterial resistance

Bassetti, Stefano; Tschudin‐Sutter, Sarah; Egli, Adrian; Osthoff, Michael

doi:10.1016/j.ejim.2022.01.029

Cited by 93 publications

(42 citation statements)

References 66 publications

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“…Since their introduction in the 1940s, antibiotics have been heavily applied to treat infectious diseases. After the “Golden Age” of antibiotics, semisynthetic and chemically modified antibiotics have been deemed as the bright way to develop new antibiotics [ 33 , 34 , 35 , 36 , 37 ]. However, these innovative compounds cannot address the antibiotic-resistant issues as bacteria could rapidly acquire tolerance after a period of gene response.…”

Section: Supramolecular Self-assembly Of Antibioticsmentioning

confidence: 99%

Combatting Antibiotic Resistance Using Supramolecular Assemblies

Guo

Yuan-yuan

et al. 2022

Pharmaceuticals

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Antibiotic resistance has posed a great threat to human health. The emergence of antibiotic resistance has always outpaced the development of new antibiotics, and the investment in the development of new antibiotics is diminishing. Supramolecular self-assembly of the conventional antibacterial agents has been proved to be a promising and versatile strategy to tackle the serious problem of antibiotic resistance. In this review, the recent development of antibacterial agents based on supramolecular self-assembly strategies will be introduced.

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Section: Supramolecular Self-assembly Of Antibioticsmentioning

confidence: 99%

Combatting Antibiotic Resistance Using Supramolecular Assemblies

Guo

Yuan-yuan

et al. 2022

Pharmaceuticals

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“…Recent studies have revealed that global antibiotic usage in human medicine is rising. However, incorrect antibiotic prescribing is still expected; it is estimated that up to half of all antimicrobials administered to people are unnecessary [ 5 , 9 ].…”

Section: Reviewmentioning

confidence: 99%

“…An excessively homogeneous usage (a few compounds/antibiotic classes) may enhance selection pressure and encourage antimicrobial resistance spread [ 5 , 50 ]. In addition, single-drug therapy may favor the formation of resistance to infections caused by some microorganisms (Bauernfeind et al, 1995) [ 51 ].…”

Section: Reviewmentioning

confidence: 99%

“…Antibiotic-resistant bacterial infections are projected to cause over 33,000 fatalities in Europe each year, and antimicrobial resistance is expected to generate 10 million deaths worldwide by 2050 [ 5 , 6 ]. The complexity of the processes that accord with the emergence of resistance cannot be overstated in the case of antimicrobial agents, and an absence of basic knowledge on these topics is one of the hurdles for the failure of significant progress in the effective prevention and control of resistance development [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

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Unraveling the Nature of Antibiotics: Is It a Cure or a New Hurdle to the Patient Treatment?

Gude¹,

Gopal²,

Ramesh³

et al. 2022

Cureus

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“…Accordingly, antibiotics are preferentially used to strengthen their antibacterial effect. Regrettably, long term and abuse of antibiotics lead to the occurrence of bacterial resistance (Auzin et al., 2021 ; Lai et al., 2021 ; Bassetti et al., 2022 ). As predicted by World Health Organization (WHO), it could cause the death of nearly 10 million people each year by 2050.…”

Section: Introductionmentioning

confidence: 99%

Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy

Guo

Zeng

et al. 2022

Drug Delivery

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The development of novel wound dressings, such as aerogels, with rapid hemostasis and bactericidal capacities for pre-hospital care is necessary. To prevent the occurrence of bacterial resistance, antibacterial photodynamic therapy (aPDT) with broad-spectrum antibacterial ability and negligible bacterial resistance has been intensively studied. However, photosensitizers often suffer from poor water solubility, short singlet oxygen ( 1 O 2 ) half-life and restricted 1 O 2 diffusion distance. Herein, sodium alginate was covalently modified by photosensitizers and phenylboronic acid, and cross-linked by Ca(II) ions to generate SA@TPAPP@PBA aerogel after lyophilization as an antibacterial photodynamic wound dressing. Afterwards, its photodynamic and bacterial capture activities were intensively evaluated. Furthermore, its hemostasis and bactericidal efficiency against Staphylococcus aureus were assessed via in vitro and in vivo assays. First, chemical immobilization of photosensitizers led to an enhancement of its solubility. Moreover, it showed an excellent hemostasis capacity. Due to the formation of reversible covalent bonds between phenylboronic acid and diol groups on bacterial cell surface, the aerogel could capture S. aureus tightly and dramatically enhance aPDT. To sum up, the prepared aerogel illustrated excellent hemostasis capacity and antibacterial ability against S. aureus . Therefore, they have great potential to be utilized as wound dressing in clinical trials.

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Optimizing antibiotic therapies to reduce the risk of bacterial resistance

Cited by 93 publications

References 66 publications

Combatting Antibiotic Resistance Using Supramolecular Assemblies

Combatting Antibiotic Resistance Using Supramolecular Assemblies

Unraveling the Nature of Antibiotics: Is It a Cure or a New Hurdle to the Patient Treatment?

Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy

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