Optimizing extraction conditions for functional compounds from ginger (Zingiber officinale Roscoe) using response surface methodology

Cha, Jaeyoon; Kim, Chong-Tai; Cho, Yong-Jin

doi:10.1007/s10068-019-00667-9

Cited by 11 publications

(10 citation statements)

References 23 publications

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“…Both the R 2 and adjusted R 2 values were greater than 80%. This confirms that the model exhibits precise prediction for the designated responses [40][41][42]. The lack of fit is the parameter used for confirming the validity of the models.…”

Section: Regression Modeling Of the Swe Conditions On Tpc Aa And T-cqasupporting

confidence: 67%

“…BBD is an independent rotatable quadratic design with no embedded factorial or fractional factorial points [36,37]. It has been commonly used for the optimization of plant material extraction processes [39][40][41][42]. In this study, the effects of the three independent variables (i.e., extraction temperature of 120-240 • C, time of 10-60 min, and the solid-liquid ratio of 1:10-1:40 g/mL) on the response (Y) were investigated.…”

Section: Experimental Designmentioning

confidence: 99%

“…As presented in Table 3, the values of R 2 (pred) for the TPC, AA, and T-CQA are in agreement with R 2 (adj). For a value higher than 75%, the regression model can predict the designated response very well [36,[38][39][40]42]. A multiple regression analysis was implemented to determine the coefficients and equations, which can be used to estimate the responses (i.e., TPC, AA, and T-CQA).…”

Section: Regression Modeling Of the Swe Conditions On Tpc Aa And T-cqamentioning

confidence: 99%

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Valorization of Coffee Silverskin through Subcritical Water Extraction: An Optimization Based on T-CQA Using Response Surface Methodology

et al. 2022

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Coffee silverskin (CS) is the only byproduct of the roasting process for coffee beans and is rich in phenolic compounds with various bioactivities. This study proposes a valorization option for bioactive compounds (T-CQA) based on a subcritical water extraction (SWE) technique, which is known for its high efficiency and feasibility for use on an industrial scale. The use of water as a sole solvent requires a minimum number of cleaning steps and renders the extract safe for further applications, such as in either the cosmetic or food industry. Response surface methodology with a Box–Behnken design is effectively used to optimize and explain the individual and interactive process variables (i.e., extraction temperature, extraction time, and solid–liquid ratio) on the T-CQA content obtained from coffee silverskin by the SWE technique. The final model exhibits a precise prediction of the experimental data obtained for the maximum T-CQA content. Under the optimum conditions, the CS extract is found to contain a higher content of T-CQA and TPC than that reported previously. For antioxidant activity, up to 26.12 ± 3.27 mg Trolox equivalent/g CS is obtained.

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Section: Regression Modeling Of the Swe Conditions On Tpc Aa And T-cqasupporting

confidence: 67%

Section: Experimental Designmentioning

confidence: 99%

Section: Regression Modeling Of the Swe Conditions On Tpc Aa And T-cqamentioning

confidence: 99%

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Valorization of Coffee Silverskin through Subcritical Water Extraction: An Optimization Based on T-CQA Using Response Surface Methodology

et al. 2022

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“…One of its major strength over others is its effectiveness in reducing the number of experiments when compared with full factorial experimental design techniques. The RSM approach have been reported to be used not only for operation but to design, develop and improve production processes in which a response is influenced by multiple variables [10][11][12]. It has found wide application in meat and meat products to obtain acceptable processing condition.…”

Section: Introductionmentioning

confidence: 99%

Influence of frying parameters and optimization of deep fat frying conditions on the physicochemical and textural properties of chicken nuggets from FUNAAB-Alpha broilers

et al. 2021

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Influence of deep fat frying parameters on quality attributes of chicken nuggets from FUNAAB-Alpha broilers and optimization of the process using Box-Behnken experimental design of response surface methodology was investigated. Fried chicken nuggets were obtained using frying temperature (155–175 °C), frying time (3–7 min) and sample thickness (0.5–2.5 cm) as independent variables. Oil and moisture contents, texture (hardness, chewiness, adhesiveness, cohesiveness and springiness) and colour (L*, a* and b*) of samples were analyzed using standard procedures. Significance of each term in polynomial regression equations was evaluated on quality attributes. The accuracy of the regression models varied between 0.727 and 0.939. The effect of frying temperature on quality attributes of fried chicken nuggets was more significant (p > 0.05). The optimum frying temperature, frying time and sample thickness are determined as 175 °C, 3 min, 2.32 cm, respectively. Absolute percent error between optimized and experimental data were within the acceptable limit. Graphic abstract

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“…The optimal condition for extracting the functional compounds of ginger, such 6-gingerol, and 6-shogaol, is to use 70% ethanol at 62.29°C -70°C for 52 -70 min (34). Thus, 20 g of the dried powder of ginger rhizomes was obtained from the Isfahan Agricultural and Natural Resources Research Center (Isfahan, Iran).…”

Section: Preparation Of Hydroalcoholic Gementioning

confidence: 99%

Ginger Extract Modulates the Production of Chemokines CCL17, CCL20, CCL22, and CXCL10 and the Gene Expression of Their Receptors in Peripheral Blood Mononuclear Cells from Peptic Ulcer Patients Infected with Helicobacter pylori

Jalalpour

Mirzaee

Taheri

et al. 2021

Jundishapur J Nat Pharm Prod

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Background: The imbalanced expression of chemokines plays critical role in the development of Helicobacter pylori-mediated complications. Objectives: Our aim was to determine ginger extract (GE) effects on the expression of chemokines CCL17, CCL20, CCL22, and CXCL10, as well as CCR4, CCR6, and CXCR3 receptors by peripheral blood mononuclear cells (PBMCs) from H. pylori -infected patients with peptic ulcer (PU). Methods: Peripheral blood mononuclear cells were obtained from 20 patients with H. pylori-associated PU, 20 H. pylori-infected asymptomatic subjects (HAS), and 20 non-infected healthy subjects (NHS). The PBMCs were stimulated by 10 µg/mL of H. pylori-derived crude extract (HPCE) in the presence of 0, 10, 20, and 30 µg/mL of GE. After 36 hours, the supernatant and the RNA extracted from the cells were tested for chemokine concentration and chemokine receptor expression using ELISA and real-time PCR techniques, respectively. Results: In PU patients, treating HPCE-stimulated PBMCs with 10, 20, or 30 µg/mL GE reduced the production of CXCL10 (1.47, 1.5, and 1.53 folds, respectively, P < 0.001 for all), CCL20 (1.44, 1.62, and 1.65 folds, respectively, P < 0.003), and treatment with 30 µg/mL GE increased CCL17 (1.28-fold, P < 0.001) and CCL22 (1.59-fold, P < 0.001) production compared with untreated HPCE-stimulated PBMCs. In PU patients, the HPCE-stimulated PBMCs treated with 10, 20, or 30 µg/mL GE expressed lower levels of CXCR3 (1.9, 3, and 3.5 folds, respectively, P < 0.001) and CCR6 (2.3, 2.7, and 2.8 folds, respectively, P < 0.002) while treating with 10 µg/mL GE upregulated CCR4 (1.7 fold, P = 0.003) compared with untreated HPCE-stimulated PBMCs. Conclusions: Ginger extract modulated the expression of chemokines and their receptors in the PBMCs derived from H. pylori-infected PU patients. The therapeutic potentials of ginger for treating HP-related complications need to be further explored.

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Optimizing extraction conditions for functional compounds from ginger (Zingiber officinale Roscoe) using response surface methodology

Cited by 11 publications

References 23 publications

Valorization of Coffee Silverskin through Subcritical Water Extraction: An Optimization Based on T-CQA Using Response Surface Methodology

Valorization of Coffee Silverskin through Subcritical Water Extraction: An Optimization Based on T-CQA Using Response Surface Methodology

Influence of frying parameters and optimization of deep fat frying conditions on the physicochemical and textural properties of chicken nuggets from FUNAAB-Alpha broilers

Ginger Extract Modulates the Production of Chemokines CCL17, CCL20, CCL22, and CXCL10 and the Gene Expression of Their Receptors in Peripheral Blood Mononuclear Cells from Peptic Ulcer Patients Infected with Helicobacter pylori

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