2012
DOI: 10.1039/c2sm25652e
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Optimizing layer-by-layer deposition of interpolymer complexes on solid substrates using Biacore

Abstract: The layer-by-layer deposition of polymers onto surfaces allows the fabrication of multilayered materials for a wide range of applications, from drug delivery to biosensors. This work describes the analysis of complex formation between poly(acrylic acid) and methylcellulose in aqueous solutions using Biacore, a surface plasmon resonance analytical technique, traditionally used to examine biological interactions. This technique characterized the layer-by-layer deposition of these polymers on the surface of a Bia… Show more

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Cited by 8 publications
(10 citation statements)
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“…The thermodynamics of the TA interaction with PAOx were qualitatively investigated by ITC revealing distinct differences for the different PAOx congeners ( Figure and Figures S5 and S6) . Upon addition of TA to PMeOx a negative change in energy was detected indicative for interactions that are enthalpy driven.…”
Section: Resultssupporting
confidence: 82%
“…The thermodynamics of the TA interaction with PAOx were qualitatively investigated by ITC revealing distinct differences for the different PAOx congeners ( Figure and Figures S5 and S6) . Upon addition of TA to PMeOx a negative change in energy was detected indicative for interactions that are enthalpy driven.…”
Section: Resultssupporting
confidence: 82%
“…Previously, we have studied the complexation between PAA and MC in aqueous solutions by turbidimetric titration, isothermal titration calorimetry, transmission electron microscopy, and surface plasmon resonance (Biacore) and evaluated the effects of pH and solution concentration on the intensity of interactions and structure of IPCs formed . Rheological properties of PAA–MC complexes in aqueous solutions were also reported by other authors .…”
Section: Introductionmentioning
confidence: 79%
“…All our previous studies of complexation between PAA and MC in aqueous solutions were focused on determination of the stoichiometry of complexation, [12,13] probing the complexation strength and thermodynamics, [14] evaluation of pH and concentration effects on the formation, structural organization, and stability of IPCs, [12][13][14] and the fabrication of PAA-MC based multilayered materials. [14][15][16] We have established the possibility of forming PAA-MC complexes as nanoparticles when 0.2 wt% polymer solutions were mixed at 30:70 wt% ratio at pHs 1.4, 2.4, and 3.2, [14] however, did not evaluate the stability of these colloidal suspensions to aggregation. In this study, we applied dynamic light scattering (DLS) to look at the effects of polymer ratio and pH on the size, size distribution and colloidal stability of IPC nanoparticles.…”
Section: Structure and Colloidal Stability Of Interpolymer Complexesmentioning
confidence: 99%
“…The initial injection of acidic compound saturates the sensor chip surface, followed by injection of the complimentary non-ionic polymer. A total of 4 injections were carried out for each sample following a standard, previously optimized layer-by-layer cycle, 33 with data selected from the interaction between layers 3 and 4.…”
Section: Spr Analysis Of the Complexation Of Acidic Compounds With Nomentioning
confidence: 99%