Optimizing primary graft function in islet allotransplantation: The Lille experience

Chetboun, Mikaël; Mapihan, Kristell Le; Gmyr, Valéry; Raverdy, Violeta; Hübert, Thomas; Caïazzo, Robert; Noël, Christian; Kerr–Conte, Julie; Vantyghem, Marie-Christine; Pattou, François

doi:10.1016/b978-0-12-814833-4.00051-4

Cited by 1 publication

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ITx was performed at Lille University Hospital between 2003 and 2017, as previously described [ 14 ]. Briefly, recipients were patients with C-peptide negative type 1 diabetes, aged from 18 to 65 years old who received an islet transplantation alone (ITA) or after kidney transplantation (IAK) in the context of three prospective trials ( ClinicalTrials.gov Identifier: NCT00446264/NCT01123187 [ 16 ] and NCT01148680 [ 26 ]) and a follow-up of at least 5 years.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Primary Graft Function and 5 Year Insulin Independence After Pancreas and Islet Transplantation for Type 1 Diabetes: A Retrospective Parallel Cohort Study

Chetboun,

Masset,

Maanaoui

et al. 2023

Transpl Int

Self Cite

View full text Add to dashboard Cite

In islet transplantation (ITx), primary graft function (PGF) or beta cell function measured early after last infusion is closely associated with long term clinical outcomes. We investigated the association between PGF and 5 year insulin independence rate in ITx and pancreas transplantation (PTx) recipients. This retrospective multicenter study included type 1 diabetes patients who underwent ITx in Lille and PTx in Nantes from 2000 to 2022. PGF was assessed using the validated Beta2-score and compared to normoglycemic control subjects. Subsequently, the 5 year insulin independence rates, as predicted by a validated PGF-based model, were compared to the actual rates observed in ITx and PTx patients. The study enrolled 39 ITx (23 ITA, 16 IAK), 209 PTx recipients (23 PTA, 14 PAK, 172 SPK), and 56 normoglycemic controls. Mean[SD] PGF was lower after ITx (ITA 22.3[5.2], IAK 24.8[6.4], than after PTx (PTA 38.9[15.3], PAK 36.8[9.0], SPK 38.7[10.5]), and lower than mean beta-cell function measured in normoglycemic control: 36.6[4.3]. The insulin independence rates observed at 5 years after PTA and PAK aligned with PGF predictions, and was higher after SPK. Our results indicate a similar relation between PGF and 5 year insulin independence in ITx and solitary PTx, shedding new light on long-term transplantation outcomes.

show abstract

Section: Methodsmentioning

confidence: 99%

“…ITx entails only a minimally invasive procedure consisting of the infusion of few milliliters of isolated pancreatic islets into the portal vein, typically using a radiological or mini-surgical approach [3,[12][13][14], resulting in limited risks.…”

Section: Introductionmentioning

confidence: 99%