Optimizing the mechanical properties of a bi-layered knitted/nanofibrous esophageal prosthesis using artificial intelligence

Abstract

Polylactide/polycaprolactone asymmetric membranes for guided bone regeneration DOI 10.1515/epoly-2016-0138 e-Polymers 2016; 16(5): 351-358 Full length article: Biodegradable polymer membranes were fabricated by a combination of electrospinning and freeze-drying. Those asymmetric membranes possess favorable mechanical properties and are biocompatible. The differentiated porosity should on one side prevent soft tissue growth and on the other be a suitable scaffold for bone cells growth. Full length article: Esophageal prostheses and scaffolds should have the appropriate mechanical and strain properties in the longitudinal and circumferential directions. A novel bi-layered esophageal prosthesis was produced using knitted tubular silk fabric and coating of polyurethane.

Modeling and optimization of the core-shell nanofibrous composite mat as a scaffold via hybrid models

“…In the following, the mechanical features of a bi-layered knitted/nanofibrous esophageal prosthesis were optimized by Yekrang et al by the use of the same procedure. 36…”

“…Thereupon, it is a challenging task to solve such multi-objective problems and select the best option. 36 Using the genetic algorithm (GA) and ANN, the nylon 66 polymerization was predicted by Leon and Curteanu. These researchers used GA for optimizing the output of a formula developed for the ANN topology and process, like the node number and connection weights and biases between the neurons in different layers.…”

“…37 Additionally, coupling the ANN-GA techniques has been extensively applied for predicting and finding the optimal parameters in scientific surveys and engineering design. 36 Besides, such method has been employed for optimizing the structural features of the biological scaffolds for meeting the needed mechanical features of native tissues. Using the same approach, the structural features of the silk tendon scaffold were optimized by Naghashzargar et al 38 Moreover, researchers have used this technique for optimizing the structural features of bone nanofibrous scaffolds so that the growth of osteoblast cells can be maximized.…”

“…In the following, the mechanical features of a bilayered knitted/nanofibrous esophageal prosthesis were optimized by Yekrang et al by the use of the same procedure. 36 To wrap it up, by using hybrid models including RSM-GA and ANN-GA, a practical approach can be used to produce such an optimum scaffold. In the present study, we undertake an optimization problem using the mentioned hybrid models to find the optimal design of PES/PVP/zeolite socony mobil-5 (ZSM-5) nanofibrous composite mat (NFCM) for scaffold applications.…”

Simulation and characterization of the mechanical properties of knitted esophageal stents using finite element and mathematical models

“…There are also some commercially available knitted stents including EGIS V R , Ultraflex V R , and Wallflex V R . In addition, there are several studies on the newly knitted stents designed esophageal treatment [9,[19][20][21][22]. While all previous studies have focused on experimental invitro characterization of the esophageal stents, less attention has been paid to modelling the behavior of these structures in practical applications.…”