Optimizing the silanization of thermally-decomposed iron oxide nanoparticles for efficient aqueous phase transfer and MRI applications

Wang, Xin-Yang; Mertz, Damien; Blanco-Andujar, Cristina; Bora, Anindita; Ménard, Mathilde; Meyer, Florent; Giraudeau, Céline

doi:10.1039/c6ra18360c

Cited by 14 publications

(14 citation statements)

References 44 publications

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“…In a previous study on the same kind of IO NPs coated with TPEDTA siloxane (free silica) instead of MS-HSA shell, we obtained a r1 of 13.9 mM -1 s -1 and a r2 of 88.6 mM -1 s -1 . [32] Our present study here on IO@MS-HSA NPs showed that the MS-HSA coating on the IO NPs did not modify importantly the r2 value as compared to IO@TPEDTA but strongly decreased the r1 leading to a higher r2/r1 ratio. This low r1 value could be explained by a limited water accessibility to the magnetic core due to the MS-HSA coating.…”

Section: Evaluation Of Mri Contrast Properties Of Io@ms-hsacontrasting

confidence: 44%

Design of hybrid protein-coated magnetic core-mesoporous silica shell nanocomposites for MRI and drug release assessed in a 3D tumor cell model

Ménard¹,

Meyer²,

Affolter-Zbaraszczuk³

et al. 2019

Nanotechnology

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In this work, we describe the design and the use of a novel theranostic hybrid nanocomposite made of an iron oxide core and a mesoporous silica shell (IO@MS) of ca. 30 nm coated by human serum albumin (HSA) layer for magnetic resonance imaging (MRI) and drug delivery applications. The porosity of IO@MS nanoparticles was loaded with an antitumoral drug, Doxorubicin (Dox) reaching a high drug loading capacity (DLC) of 34w%. To entrap the drug, a tight HSA coating held via isobutyramide (IBAM) binders was deposited. We show that this protein nanoassembly entraps the drugs efficiently and behaves as an innovative enzymesensitive gatekeeper that is degraded upon protease action. Finally we assess the Dox release in a 3D cell model via confocal imaging and its cytotoxicity is shown by growth inhibition studies on liver cancer cell spheroids.

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Section: Evaluation Of Mri Contrast Properties Of Io@ms-hsacontrasting

confidence: 44%

Design of hybrid protein-coated magnetic core-mesoporous silica shell nanocomposites for MRI and drug release assessed in a 3D tumor cell model

Ménard¹,

Meyer²,

Affolter-Zbaraszczuk³

et al. 2019

Nanotechnology

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“…4. 37,38 The peak near 686 cm À1 corresponds to both the Fe-O bond stretching of iron oxide and the amide V (a and b) of the pristine PA6. 39 However, interaction between the peaks results in the suppression of the peak near 686 cm À1 for the 22 wt.% and 55 wt.% PNCs.…”

Section: Fourier-transform Infrared Spectroscopymentioning

confidence: 99%

Effect of Oleic Acid Coating of Iron Oxide Nanoparticles on Properties of Magnetic Polyamide-6 Nanocomposite

Gupta

Pancholi

et al. 2019

JOM

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This work reports the development and testing of a magnetic polymer (Polyamide 6, PA6) nanocomposite capable of melting when exposed to an external magnetic field. Addition of high concentrations of iron oxide nanoparticles (NPs) can induce quick melting but is detrimental to the mechanical properties of the polymer. To reduce the amount of NPs required for achieving efficient melting, they should be well dispersed in the polymer. In this study, the oleic acid loading on the surfaces of the NPs was varied to study the effect of variations in coatings on the dispersion in the polymer and on the polymer melting time. The NPs functionalized with oleic acid were added to melted monomer e-caprolactam and polymerized using ring-opening polymerization. The resulting PA6 nanocomposite was characterized by Fourier-transform infrared spectroscopy, differential scanning calorimetry, x-ray diffraction and transmission electron microscopy. The results confirmed that the PA6 nanocomposite showed a decrease of 8-10% in its glass-transition temperature compared to commercial PA6. The crystallinity of the synthesized samples were found to vary between 42% and 57%. The 55 wt.% oleic acid-loaded NPs were found to disperse most efficiently in the PA6 matrix; however, some large agglomerates were formed due to excessive oleic acid. Therefore, the 22 wt.% oleic acid coating showed overall superior dispersion. Additionally, the magnetic induction response was tested by observing a melt-characteristic of the magnetic polymer composite using a model setup. Oleic acid concentration is found to affect the dispersion, melting time and crystallinity of the nanocomposite.

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“…The loading/release upon thermal response can be done using "grafting-to" and "grafting-from" methods. Graftingto strategies involve the functionalization of IONPs by polymers either by non-covalent interactions [88,116] or by strong interactions (coordination/electro-covalent) using anchoring groups such as phosphonate [72,117,118], carboxylate [119] or alkoxysilane [120][121][122][123]. In these different cases of chemisorption, multivalency is an important way to increase the binding strength e.g.…”

Section: Formulation Of Drugs and Magnetic Nps In Thermally Sensitivementioning

confidence: 99%

Drug releasing nanoplatforms activated by alternating magnetic fields

Mertz

Sandre

Bégin‐Colin

2017

Biochimica et Biophysica Acta (BBA) - General Subjects

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The use of an alternating magnetic field (AMF) to generate non-invasively and spatially a localized heating from a magnetic nano-mediator has become very popular these last years to develop magnetic hyperthermia (MH) as a promising therapeutic modality already used in the clinics. AMF has become highly attractive this last decade over others radiations, as AMF allows a deeper penetration in the body and a less harmful ionizing effect. In addition to pure MH which induces tumor cell death through local T elevation, this AMF-generated magneto-thermal effect can also be exploited as a relevant external stimulus to trigger a drug release from drug-loaded magnetic nanocarriers, temporally and spatially. This review article is focused especially on this concept of AMF induced drug release, possibly combined with MH. The design of such magnetically responsive drug delivery nanoplatforms requires two key and complementary components: a magnetic mediator which collects and turns the magnetic energy into local heat, and a thermoresponsive carrier ensuring thermo-induced drug release, as a consequence of magnetic stimulus. A wide panel of magnetic nanomaterials/chemistries and processes are currently developed to achieve such nanoplatforms. This review article presents a broad overview about the fundamental concepts of drug releasing nanoplatforms activated by AMF, their formulations, and their efficiency in vitro and in vivo. This article is part of a Special Issue entitled "Recent Advances in Bionanomaterials" Guest Editors: Dr. Marie-Louise Saboungi and Dr. Samuel D. Bader.

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Optimizing the silanization of thermally-decomposed iron oxide nanoparticles for efficient aqueous phase transfer and MRI applications

Abstract: A facile silanization method allows to efficiently stabilise in aqueous solution iron oxide NPs synthesized by thermal decomposition for MRI applications.

Cited by 14 publications

References 44 publications

Design of hybrid protein-coated magnetic core-mesoporous silica shell nanocomposites for MRI and drug release assessed in a 3D tumor cell model

Design of hybrid protein-coated magnetic core-mesoporous silica shell nanocomposites for MRI and drug release assessed in a 3D tumor cell model

Effect of Oleic Acid Coating of Iron Oxide Nanoparticles on Properties of Magnetic Polyamide-6 Nanocomposite

Drug releasing nanoplatforms activated by alternating magnetic fields

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