Optimum non-invasive predictive indicators for metabolic dysfunction-associated fatty liver disease and its subgroups in the Chinese population: A retrospective case-control study

Liu, Jing; Duan, Shaojie; Che, Wang; Wang, Yutong; Peng, Hongye; Niu, Zuohu; Yao, Shukun

doi:10.3389/fendo.2022.1035418

Cited by 5 publications

(5 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For both sexes, the optimal cut-off values for BMI were lower (27.80 kg/m 2 in males, 28.75 kg/m 2 in female) than the values indicating obesity (> 30 kg/m 2 ). The BMI cutoff points obtained by Jing Liu et al [ 23 ], Cai et al [ 11 ], and Yang et al [ 24 ] were 25.39, 24, and 24.61 kg/m2 respectively, which were lower than our findings. It is well accepted that BMI is closely related to the risk of fatty liver disease and is an important factor in determining negative clinical outcomes [ 10 ].…”

Section: Discussioncontrasting

confidence: 95%

“…Our study revealed a strong positive correlation between WC, BMI, BAI, BRI and AVI with HIS, TyG-BMI and TyG-WC, as well as between VAI with AIP, LAP, CMI and TyG Index, as indicated by Pearson’s correlation coefficients. However, some studies have shown that LAP is the best predictor of obese individuals with MAFLD, with the maximum ORs value [ 11 , 23 ]. Also, In a cross-sectional study that included 7968 participants, Yang et al [ 24 ] discovered that TyG-BMI, BMI, TyG, TG/HDL-C, and TG are five significant predictors of the risk of MAFLD.…”

Section: Discussionmentioning

confidence: 99%

“…It is well accepted that BMI is closely related to the risk of fatty liver disease and is an important factor in determining negative clinical outcomes [ 10 ]. On the contrary, Jing Liu et al [ 23 ] suggested that BMI is not a valuable diagnostic indicator for MAFLD. Nevertheless, the correlation between MAFLD and BMI is intricate and can be affected by numerous factors, including one’s racial or ethnic background and variations in specific genes [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Assessment of the appropriate cutoff points for anthropometric indices and their relationship with cardio-metabolic indices to predict the risk of metabolic associated fatty liver disease

Hosseini,

Alipour,

Sarvandian

et al. 2024

BMC Endocr Disord

View full text Add to dashboard Cite

Background Research on Metabolic Associated Fatty Liver Disease (MAFLD) is still in its early stages, with few studies available to identify and predict effective indicators of this disease. On the other hand, early diagnosis and intervention are crucial to reduce the burden of MAFLD. Therefore, the aim of this research was to investigate the effectiveness of eleven anthropometric indices and their appropriate cut-off values as a non-invasive method to predict and diagnose MAFLD in the Iranian population. Methods In this cross-sectional study, we analyzed baseline data from the Hoveyzeh Cohort Study, a prospective population-based study conducted in Iran that enrolled a total of 7836 subjects aged 35 to 70 years from May 2016 through August 2018. Results The optimal cut-off values of anthropometric indices for predicting MAFLD risk were determined for waist circumference(WC) (102.25 cm for males and 101.45 cm for females), body mass index (BMI) (27.80 kg/m2 for males and 28.75 kg/m2 for females), waist-to-hip ratio (WHR) (0.96 for both males and females), waist-to-height ratio (WHtR) (0.56 for males and 0.63 for females), body adiposity index (BAI) (23.24 for males and 32.97 for females), visceral adiposity index (VAI) (1.64 for males and 1.88 for females), weight-adjusted waist index (WWI) (10.63 for males and 11.71 for females), conicity index (CI) (1.29 for males and 1.36 for females), body roundness index (BRI) (4.52 for males and 6.45 for females), relative fat mass (RFM) (28.18 for males and 44.91 for females) and abdominal volume index (AVI) (18.85 for males and for 21.37 females). VAI in males (sensitivity: 77%, specificity: 60%, Youden’s Index: 0.37) and RFM in females (sensitivity: 76%, specificity: 59%, Youden’s Index: 0.35) were found to have higher sensitivity and specificity compared to other anthropometric indices. Furthermore, anthropometric indices demonstrated statistically significant correlations with various hepatic and cardiometabolic indices. Among these, the strongest positive correlations were observed between WC, BMI, BAI, BRI, and AVI with the Hepatic Steatosis Index (HSI), TyG-BMI, and TyG-WC, as well as between VAI and the Atherogenic Index of Plasma (AIP), Lipid Accumulation Product (LAP), Cardiometabolic Index (CMI), and the Triglyceride and Glucose (TyG) Index. Conclusion Anthropometric indices are effective in predicting MAFLD risk among Iranian adults, with WWI, VAI, and RFM identified as the strongest predictors. The proposed cutoff values could serve as a straightforward and non-invasive methods for the early diagnosis of MAFLD.

show abstract

Section: Discussioncontrasting

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Assessment of the appropriate cutoff points for anthropometric indices and their relationship with cardio-metabolic indices to predict the risk of metabolic associated fatty liver disease

Hosseini,

Alipour,

Sarvandian

et al. 2024

BMC Endocr Disord

View full text Add to dashboard Cite

show abstract

“…Chinese study revealed WTI had been a positive prognostic value of MetS in both males and females [38] . Furthermore, it should be noted that WTI has been identi ed as a potential indicator for the development of coronary artery disorders [39] and in the occurrence of Metabolic dysfunction-associated fatty liver disease (MAFLD) [40] .…”

Section: Discussionmentioning

confidence: 99%

Cardiometabolic Index (CMI), Lipid Accumulation Products (LAP), Waist Triglyceride Index (WTI), and Acute Pancreatitis (AP) Risk: A Prospective Study conducted on Adults in North China

Sun,

Du,

Ren

et al. 2023

Preprint

View full text Add to dashboard Cite

Objective: To investigate the correlation between anthropometric indexes [cardiometabolic index (CMI)，lipid accumulation products (LAP), waist triglyceride index (WTI), and body mass index (BMI)] and acute pancreatitis (AP) in a Chinese adult population. Methodology: The present investigation consisted of a prospective group including 117,326 subjects who were enrolled in the Kailuan investigation. The individuals were categorized into quartiles based on their baseline levels of CMI, LAP, and WIT. BMI was categorized into three distinctive groups: normal weight group (BMI<24 kg/m2), overweight group (BMI 24–28 kg /m2), and obesity group (BMI≥28 kg/m2). The data were subjected to analysis in order to investigate the correlation between these anthropometric indexes and the incidence of AP. Cox regression models were employed to assess the relative risk of AP while accounting for known risk factors through appropriate adjustments. Outcomes: Over the course of a median follow-up duration of 12.59+0.98 years, we documented 401 incident AP cases. Incidence density and cumulative incidence rates of AP increased with the increase of CMI, LAP, and WTI. After multivariate adjustment, the fourth quartile of CMI, LAP, and WTI exhibited the greatest risk of AP [CMI: hazard ratio (HR) 1.93, 95% confidential interval (CI) (1.45–2.57); LAP: HR 2.00, 95% CI（1.49–2.68); WTI: HR 2.13,95% CI（1.59–2.83）]. In comparison to the normal weight group, the obesity group (BMI≥28 kg/m2) had an elevated risk of AP (HR=1.58, 95% CI: 1.21–2.05). Furthermore, the incremental effect of BMI combined with CMI on the prognostic value of AP was greater than that of BMI alone (the C statistics demonstrated a result of 0.607 versus 0.546; the integrated discrimination improvement revealed a result of 0.321%; net reclassification improvement was 1.975%). Conclusion: We found that CMI, LAP, and WTI were positively and independently connected to the risk of AP. Additionally, CMI demonstrates a superior prognostic capacity than other indexes in anticipating AP.

show abstract

“…Transient elastography (FibroScan) is a tool used to evaluate liver fatty infltration and fbrosis by measuring liver stifness but not available in routine physical examinations, especially in primary care [6]. Some anthropometric indexes used to diagnose MAFLD are with complex calculations and controversial diagnostic abilities [7]. Terefore, a noninvasive and convenient serum biomarker is required for the classifcation of the MAFLD severity.…”

Section: Introductionmentioning

confidence: 99%

Correlation between the Severity of Metabolic Dysfunction-Associated Fatty Liver Disease and Serum Uric Acid to Serum Creatinine Ratio

Liu

Peng

Wang

et al. 2023

International Journal of Endocrinology

Self Cite

View full text Add to dashboard Cite

Purpose. As one of the most common chronic liver diseases, metabolic dysfunction-associated fatty liver disease (MAFLD) had different prognoses between mild and moderate-severe levels. Serum uric acid to serum creatinine ratio (sUA/Cr) can reflect the overall metabolic status of the body. To explore a convenient indicator to screen MAFLD and distinguish the severity of the disease, this study analyzed the correlation between sUA/Cr and the severity of MAFLD. Methods. 228 participants were enrolled and divided into 2 groups, including mild MAFLD and non-MAFLD group and moderate-severe MAFLD group, based on liver/spleen computed tomography (CT) ratios. The correlations between sUA/Cr and the severity of MAFLD were analyzed by logistic and linear regression. Receiver operating characteristics (ROCs) analyzed the predictive ability of sUA/Cr for the severity of MAFLD expressed by the area under curve (AUC). Results. The level of sUA/Cr was higher in themoderate-severe MAFLD group than mild MAFLD and non-MAFLD group (6.14 ± 1.55 vs. 5.51 ± 1.19, P = 0.008 ). After adjustment for confounders, the correlation analysis showed that patients with elevated sUA/Cr had a higher risk of moderate-severe MAFLD (OR: 1.350, P = 0.036 ). A higher sUA/Cr level was associated with lower liver CT values (β = −0.133, P = 0.039 ) and liver/spleen CT ratio (β = −0.154, P = 0.016 ). sUA/Cr had the ability to discriminate the severity of MAFLD (AUC: 0.623). Conclusion. sUA/Cr was positively associated with the risk of moderate-severe MAFLD and had the predictive ability to discriminate the moderate-severe MAFLD from mild MAFLD and non-MAFLD. The sUA/Cr level was suggested to be monitored and controlled in the screening and treatment of MAFLD.

show abstract

Optimum non-invasive predictive indicators for metabolic dysfunction-associated fatty liver disease and its subgroups in the Chinese population: A retrospective case-control study

Cited by 5 publications

References 45 publications

Assessment of the appropriate cutoff points for anthropometric indices and their relationship with cardio-metabolic indices to predict the risk of metabolic associated fatty liver disease

Assessment of the appropriate cutoff points for anthropometric indices and their relationship with cardio-metabolic indices to predict the risk of metabolic associated fatty liver disease

Cardiometabolic Index (CMI), Lipid Accumulation Products (LAP), Waist Triglyceride Index (WTI), and Acute Pancreatitis (AP) Risk: A Prospective Study conducted on Adults in North China

Correlation between the Severity of Metabolic Dysfunction-Associated Fatty Liver Disease and Serum Uric Acid to Serum Creatinine Ratio

Contact Info

Product

Resources

About