We investigate the effect of proton-skin thickness on the α decay process. We consider 188 neutrondeficient nuclei belonging to the isotopic chains from Te (Z = 52) to Pb (Z = 82). The calculations of the half-life are carried out in the framework of the preformed cluster model, with the Wentzel-Kramers-Brillouin penetration probability and assault frequency. It is shown that the proton-skin thickness (∆p) of the daughter nucleus gives rise to a total α-daughter nucleus interaction potential of relatively wide deep internal pocket and a thinner Coulomb barrier of less height. This increases the penetration probability but decreases the assault frequency. The overall impact of the proton-skin thickness appears as a decrease in the decay half-life. The proton-skin thickness decreases the stability of the nucleus. The half-lives of the proton-skinned isotopes along the isotopic chain decrease exponentially with increasing the proton-skin thickness, whereas the Qα-value increases with ∆p. α-decay manifests itself as the second favorite decay mode of neutron-deficient nuclei, next to the β + -decay and before proton-decay. It is indicated as main, competing, and minor decay mode, at 21%, 7%, and 57%, respectively, of the investigated nuclei.