A permanent challenge that chemists in the field of (stereoselective) organic synthesis face, is the search for the ideal type of (catalytic) reaction and catalyst for their desired transformation. At this stage, often the fields of biocatalysis and chemocatalysis/"classic" chemical synthesis are considered as "competitors". Besides this question of which is the better choice for a specific synthetic task it is, however, important to state that both fields represent attractive and widely applied technologies, thus making valuable solutions for challenging organic synthetic transformations (and technical-scale processes) possible. Accordingly, rather than looking at the clear differences that separate these fields, it might be a promising alternative to focus on what unifies them. The combination of chemocatalysis and biocatalysis in multistep organic synthetic processes has turned out to be of high interest, and, for example, running these processes without isolation of an intermediate as an one-pot process can also further contribute to the development of more sustainable synthetic methods, as time-and capacity-consuming steps, as well as waste-producing steps, can be minimized. Based on the tremendous contributions made already in the field of chemoenzymatic synthesis, this field offers exciting perspectives for the future development of both highly efficient and sustainable synthetic processes. Also an increased number of technical scale operations of such concepts can certainly be expected in the future. This cluster issue about chemoenzymatic syntheses presents the current progress in this exciting field.A Minireview from the group of Park and Kim reflects the impressive state of art in dynamic kinetic resolution of amines and amino acids by means of a combination of metal-catalyzed racemization and enzymatic resolution. Furthermore, the same group reports new results of an efficient Ru complex for racemization of chiral secondary alcohols and the extension of Discover this journal online at: