Options for radiotherapy in the treatment of liver metastases

Blesa, Joan Manuel Gasent; Dawson, Laura A.

doi:10.1007/s12094-008-0264-z

Cited by 3 publications

(2 citation statements)

References 52 publications

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“…Patients were subdivided into those who received <21 radiation fractions, generally considered palliative therapy, and ≥ 21 radiation fractions, generally considered therapy with curative intent. The cut-off of 21 was set based on the results of previous studies investigating palliative radiotherapy regimens [ 23 , 26 – 29 ]. In the two sequential treatment groups, the intervals in weeks from the last day of radiotherapy to the first day of bevacizumab and from the last day of bevacizumab to the first day of radiotherapy were determined.…”

Section: Methodsmentioning

confidence: 99%

“…In real-world practice settings, however, conditions may arise necessitating simultaneous radiotherapy and bevacizumab. For example, CRC patients with liver metastases being treated with systemic chemotherapy and bevacizumab may experience severe abdominal pain arising from the tumor mass, and may therefore be considered for radiotherapy of the liver to control these symptoms [ 23 ]. At present, there are no professional guidelines for the use of simultaneous or sequential radiotherapy and bevacizumab, including the interval between the two treatments.…”

Section: Introductionmentioning

confidence: 99%

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Patterns of prescribing radiotherapy and bevacizumab in nationwide practice – analysis of 101 designated cancer care hospitals in Japan

Tsukada

Nakamura

Iwamoto³

et al. 2015

J Radiat Res

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Radiotherapy and bevacizumab are each effective in treating patients with advanced cancer, but their concurrent use may cause serious adverse events (SAEs). Whereas sequential administration can theoretically reduce the risk of SAEs while maintaining the anticancer effects, this hypothesis remains unconfirmed, leading to variations in practice. To elucidate current practices, the patterns of care received by patients in Japan with regard to these two therapies were assessed in a large database of a hospital-based cancer registry linked with insurance claims. This database contained information on 106 057 patients diagnosed with seven major cancers in 2011 and the care they received up to the end of 2012. In total, 335 patients from 101 hospitals in the database were treated with both radiotherapy and bevacizumab. Of these patients, 50.8% had lung cancer, and 51.3% had Stage IV cancer. Of the 335 patients, 75 (22.4%) received these therapies concurrently. In patients treated sequentially, the time from the last dose of bevacizumab to the start of radiotherapy was most frequently 4–5 weeks (12.4%), whereas the time from the end of radiotherapy to the start of bevacizumab was most frequently 1–2 weeks (10.6%). The cumulative proportions of patients in these two groups receiving sequential therapies within 3 weeks were 19.0% and 26.1%, respectively. Many practices appeared to avoid the concurrent use of bevacizumab and radiation, but some provided concurrent therapy. Additional data are required to determine whether the avoidance of concurrent use should become a standard of care.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Patterns of prescribing radiotherapy and bevacizumab in nationwide practice – analysis of 101 designated cancer care hospitals in Japan

Tsukada

Nakamura

Iwamoto³

et al. 2015

J Radiat Res

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Radiation Therapy for the Older Patient

Wu¹,

McCloskey²,

Steinberg³

2012

Management of Cancer in the Older Patient

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Definition of Tumor Volume Based on 18F-Fludeoxyglucose Positron Emission Tomography in Radiation Therapy for Liver Metastases: An Relational Analysis Study between Image Parameters and Image Segmentation Methods

et al. 2013

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The surgical resection was occurred mainly in liver metastasis before the development of radiation therapy techniques. Recently, Radiation therapy is increased gradually due to the development of radiation dose delivery techniques. 18F-FDG PET image showed better sensitivity and specificity in liver metastasis detection. This image modality is important in the radiation treatment with planning CT for tumor delineation. In this study, we applied automatic image segmentation methods on PET image of liver metastasis and examined the impact of image factors on these methods. We selected the patients who were received the radiation therapy and 18F-FDG PET/CT in Korea Cancer Center Hospital from 2009 to 2012. Then, three kinds of image segmentation methods had been applied; The relative threshold method, the Gradient method and the region growing method. Based on these results, we performed statistical analysis in two directions. 1. comparison of GTV and image segmentation results. 2. performance of regression analysis for relation between image factor affecting image segmentation techniques. The mean volume of GTV was 60.9±65.9 cc and the GTV40% was 22.43±35.27 cc, and the GTV50% was 10.11±17.92 cc, the GTVRG was 32.89±36.84 cc, the GTVGD was 30.34±35.77 cc, respectively. The most similar segmentation method with the GTV result was the region growing method. For the quantitative analysis of the image factors which influenced on the region growing method, we used the standardized coefficient β, factors affecting the region growing method show GTV, TumorSUVMAX/MIN, SUVmax, TBR in order. The result of the region growing (automatic segmentation) method showed the most similar result with the CT based GTV and the region growing method was affected by image factors. If we define the tumor volume by the auto image segmentation method which reflect the PET image parameters, more accurate and consistent tumor contouring can be done. And we can irradiate the optimized radiation dose to the cancer, ultimately.

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Options for radiotherapy in the treatment of liver metastases

Cited by 3 publications

References 52 publications

Patterns of prescribing radiotherapy and bevacizumab in nationwide practice – analysis of 101 designated cancer care hospitals in Japan

Patterns of prescribing radiotherapy and bevacizumab in nationwide practice – analysis of 101 designated cancer care hospitals in Japan

Radiation Therapy for the Older Patient

Definition of Tumor Volume Based on 18F-Fludeoxyglucose Positron Emission Tomography in Radiation Therapy for Liver Metastases: An Relational Analysis Study between Image Parameters and Image Segmentation Methods

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