Optochemical Sensor for an Ornidazole Assay Using 1-Amino-4-allyloxyanthraquinone as a Fluorescent Indicator

An Ultrastable Luminescent Metal–Organic Framework for Selective Sensing of Nitroaromatic Compounds and Nitroimidazole-Based Drug Molecules

“…Metronidazoles (MNZ), ornidazole (ONZ), dimetridazole (DMZ), and 2-methyl-5-nitroimidazole (2-M-5-MZ) are all nitroimidazole-based drugs. MNZ is used to treat diseases caused by bacterium and anaerobic protozoan infections. , ONZ is active against protozoa and anaerobic bacteria, and is used like MNZ in the prevention and treatment of susceptible protozoal infections and anaerobic bacterial infections . Long-term use of MNZ or ONZ leads to drug resistance, which poses health hazards to consumers.…”

“…1,2 ONZ is active against protozoa and anaerobic bacteria, and is used like MNZ in the prevention and treatment of susceptible protozoal infections and anaerobic bacterial infections. 3 Long-term use of MNZ or ONZ leads to drug resistance, which poses health hazards to consumers. When MNZ accumulates in human body, some toxic effects including seizures and peripheral neuropathy can occur, which is harmful to the health of both humans and wildlife.…”

A novel fluorescence sensor based on covalent immobilization of 3-amino-9-ethylcarbazole by using silver nanoparticles as bridges and carriers

“…Immobilization techniques of indicator dyes have significant effects on the performance of the optical sensors in terms of sensitivity and stability. The indicator dyes can be physically [1][2][3][4][5][6][7][8][9][10] and chemically [11][12][13][14][15][16][17][18][19] immobilized onto the support matrixes. Physical techniques are very simple ways to immobilize indicator dyes and can give high yields at low cost, the durability of the sensing layers fabricated thereby is relatively poor since the indicator dyes can be easily leaked out of the matrixes.…”

“…Tan). [16][17][18][19], the obtained sensors showed no dye-leaching, but it was difficult to control the thickness of the sensing films in the preparing process of sensors, and sometimes it was not easy to restore the fluorescence intensity of the sensor to the blank value by simply rinsing after the sensor was used. The reason is that the indicator dyes or dye-analyte complexes are distributed in the total sensing layer rather than on its outmost surface.…”

Synthesis and Biological Evaluation of Thiosemicarbazone Analogues of Ornidazole as Antifungal Agents

“…Most of the derivatives showed most promising antifungal and antibacterial action (MIC = 0.25 μg/mL) when compared with fluconazole. [21] Frank et al, (2007) carried out the microwave-assisted synthesis of 5-substituted-2-(2-methyl-4-nitro-1-imidazomethyl)-1,3,4-oxazoles (7) with nitroimidazole nucleus and their anti-inflammatory, antifungal, and antibacterial activity. Compounds (7a-d) show good antifungal activity.…”