Oral administration of an IL-10–secreting Lactococcus lactis strain prevents food-induced IgE sensitization

Frossard, C; Steidler, Lothar; Eigenmann, Philippe

doi:10.1016/j.jaci.2006.12.615

Cited by 134 publications

(84 citation statements)

References 26 publications

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“…In another study, it was shown that oral administration of an IL-10-secreting Lc. lactis strain could prevent food-induced IgE sensitization in a mouse model of food allergy (Frossard et al, 2007). These studies confirm that IL-10 secreting LAB hold potential for the treatment of many inflammatory diseases where this cytokine acts as a modulating compound.…”

Section: Il-10 Producing Strainssupporting

confidence: 64%

Prospective Uses of Genetically Engineered Lactic Acid Bacteria for the Prevention of Inflammatory Bowel Diseases

LeBlanc¹,

Carmen²,

Lima³

et al. 2012

Current Concepts in Colonic Disorders

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Section: Il-10 Producing Strainssupporting

confidence: 64%

Prospective Uses of Genetically Engineered Lactic Acid Bacteria for the Prevention of Inflammatory Bowel Diseases

LeBlanc¹,

Carmen²,

Lima³

et al. 2012

Current Concepts in Colonic Disorders

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“…Due to the proinflammatory functions of IL-6 and OSM, their release during a reaction likely contributes to the symptoms of anaphylaxis. In contrast, IL-10 has been found to reduce anaphylaxis following the challenge of sensitized mice [22-24]. The upregulation and release of IL-10 evident in our cohort likely represents a counter-regulatory response to restore homeostasis.…”

Section: Discussionmentioning

confidence: 57%

Markers Involved in Innate Immunity and Neutrophil Activation are Elevated during Acute Human Anaphylaxis: Validation of a Microarray Study

Francis¹,

Bosio²,

Stone³

et al. 2018

J Innate Immun

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Background: We have previously identified the upregulation of the innate immune response, neutrophil activation, and apoptosis during anaphylaxis using a microarray approach. This study aimed to validate the differential gene expression and investigate protein concentrations of “hub genes” and upstream regulators during anaphylaxis. Methods: Samples were collected from patients with anaphylaxis on their arrival at the emergency department, and after 1 and 3 h. mRNA levels of 11 genes (interleukin-6 [IL-6], IL-10, oncostatin M [OSM], S100A8, S100A9, matrix metalloproteinase 9 [MMP9], FASL, toll-like receptor 4 [TLR4], MYD88, triggering receptor expressed on myeloid cells 1 [TREM1], and cluster of differentiation 64 [CD64]) were measured in peripheral blood leucocytes using qPCR. Serum protein concentrations were measured by ELISA or cytometric bead array for 6 of these candidates. Results: Of 69 anaphylaxis patients enrolled, 36 (52%) had severe reactions, and 38 (55%) were female. Increases in both mRNA and protein of IL-10, S100A9, MMP9, and TREM1 were observed. OSM, S100A8, TLR4, and CD64 were upregulated and IL-6 protein concentrations were increased during anaphylaxis. Both FASL and soluble Fas ligand decreased during anaphylaxis. Conclusion: These results provide evidence for the involvement of innate immune pathways and myeloid cells during human anaphylaxis, validating previous microarray findings. Elevated S100A8, S100A9, TLR4, and TREM1 expression, and increased S100A9 and soluble TREM1 protein concentrations strongly suggest that neutrophils are activated during acute anaphylaxis.

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“…This might suggest that these nonnutrients when incorporated into functional foods and consumed by subjects suffering from a disease caused by a Th2 dominant immune response, may have beneficial health effects. In allergy treatment, this concept of using Th1 skewing, either or not via targeting the Treg or Th1 subfractions, as intervention target has been discussed for many years and only recently used successfully in vivo by Frossard and co-workers (43,44). Possible beneficial effects of plant sterols on the impaired Th1 response in HIV patients, have been shown by Breytenbach et al (14).…”

Section: Discussionmentioning

confidence: 99%

TLR2 Activation Is Essential to Induce a Th1 Shift in Human Peripheral Blood Mononuclear Cells by Plant Stanols and Plant Sterols

Brüll

Mensink

Hurk

et al. 2010

Journal of Biological Chemistry

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Plant sterols may induce a Th1 shift in humans. However, whether plant stanols have similar effects as well as the underlying mechanism are unknown. We have now shown that (like sitosterol) sitostanol, both 4-desmethylsterols, induces a Th1 shift when added in vitro at physiological concentrations to human PBMCs. This conclusion was based on a higher IFN␥ production, with no change in the production of IL-4 and IL-10. ␣-Amyrin, a 4.4-dimethylsterol, had comparable effects. Because 4.4-dimethylsterols cannot activate transcription factor LXR, this finding indicates that LXR activation was not involved. Sitosterol and sitostanol did not alter the production of IL-12 and IL-18 in PBMCs as well as in monocyte-derived U937 cells, suggesting that plant sterols directly affect T-helper cells, without activating APCs. However, in PBMCs treated with a TLR2 blocker (T2.5), IFN␥ production was completely inhibited, whereas blocking TLR4 with HTA125 had no such effect. To confirm these findings, PBMCs from TLR2 ؊/؊ mice were cultured in the presence of sitosterol and sitostanol. In these cells, no Th1 shift was observed. Our results, therefore, indicate that TLR2 activation is essential to induce a Th1 shift in human PBMCs by plant stanols and plant sterols.The human body responds to infectious challenges by a wide variety of cellular and humoral responses, in which numerous cells and factors play a role. During these responses, CD4 ϩ

show abstract

Oral administration of an IL-10–secreting Lactococcus lactis strain prevents food-induced IgE sensitization

Cited by 134 publications

References 26 publications

Prospective Uses of Genetically Engineered Lactic Acid Bacteria for the Prevention of Inflammatory Bowel Diseases

Prospective Uses of Genetically Engineered Lactic Acid Bacteria for the Prevention of Inflammatory Bowel Diseases

Markers Involved in Innate Immunity and Neutrophil Activation are Elevated during Acute Human Anaphylaxis: Validation of a Microarray Study

TLR2 Activation Is Essential to Induce a Th1 Shift in Human Peripheral Blood Mononuclear Cells by Plant Stanols and Plant Sterols

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