Oral Administration of Compound Probiotics Ameliorates HFD-Induced Gut Microbe Dysbiosis and Chronic Metabolic Inflammation via the G Protein-Coupled Receptor 43 in Non-alcoholic Fatty Liver Disease Rats

Liang, Yubin; Shen, Liang; Zhang, Yupei; Deng, Yuxuan; He, Yong; Chen, Yanning; Liu, Chan; Lin, Chih‐Sheng; Yang, Qin

doi:10.1007/s12602-017-9378-3

Cited by 104 publications

(71 citation statements)

References 50 publications

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“…Verrucomicrobia was reported to improve glucose metabolism in mice 26 , and recent systematic reviews found adults with obesity and T2DM had fewer Verrucomicrobia than healthy individuals 27,28 . In contrast, another study observed that the proportion of Verrucomicrobia increased in the HFD group 29,30 , which agrees with our results. Furthermore, Tang et al 31 found that Verrucomicrobia was positively correlated with cholic acid, which signi cantly increased in male rats in the NAFLD model.…”

Section: Discussionsupporting

confidence: 92%

Sex differences in gut microbiome in high-fat-diet fed rats.

Shi

Yue

Lin

et al. 2020

Preprint

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Background Sex differences in obesity and related metabolic diseases are well recognized, however, the mechanism has not been elucidated. Gut microbiota and its metabolites may play a vital role in the development of obesity and metabolic diseases. The aim of the present study was to investigate sex differences in gut microbiota and its metabolites in a high-fat-diet (HFD) obesity rats and identify microbiota genera potentially contributing to such differences in obesity and non-alcoholic fatty liver disease (NAFLD) susceptibility. Results Sprague–Dawley rats were divided into the following groups (seven animals per group): (1) male rats on a normal diet (MND), (2) male rats on HFD (MHFD), (3) female rats on a normal diet (FND), and (4) female rats on HFD (FHFD). HFD induced more body weight gain and fat storage in female rats, however, lower hepatic steatosis in FHFD than in MHFD rats was observed. When considering gut microbiota composition, FHFD rats had lower microbiome diversity than MHFD. A significant increase of Firmicutes phylum and Bilophila genus was detected in MHFD rats, as compared with FHFD, which showed increased relative abundance of Murimonas and Roseburia . Moreover, propionic and lauric acid levels were higher in FHFD than those in MHFD rats. Conclusion HFD induced sex-related alterations in gut microbiome and fatty acids. Furthermore, the genus Bilophila and Roseburia might contribute to sex differences observed in obesity and NAFLD susceptibility.

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Section: Discussionsupporting

confidence: 92%

Sex differences in gut microbiome in high-fat-diet fed rats.

Shi

Yue

Lin

et al. 2020

Preprint

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“…Unlike other SCFAs, the role of valeric acid in gut health is not fully understood. In a limited number of studies, it was found that valeric acid can stimulate the growth of intestinal epithelium and have a beneficial effect on the pathogenesis of diseases such as colitis, cardio-metabolic diseases and cancer (Table 4) [79][80][81]. Table 4.…”

Section: Pparγ (Peroxisome Proliferator-activated Receptor Gamma)mentioning

confidence: 99%

The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome

2020

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The relationship between diet and the diversity and function of the intestinal microbiome and its importance for human health is currently the subject of many studies. The type and proportion of microorganisms found in the intestines can determine the energy balance of the host. Intestinal microorganisms perform many important functions, one of which is participation in metabolic processes, e.g., in the production of short-chain fatty acids—SCFAs (also called volatile fatty acids). These acids represent the main carbon flow from the diet to the host microbiome. Maintaining intestinal balance is necessary to maintain the host’s normal health and prevent many diseases. The results of many studies confirm the beneficial effect of probiotic microorganisms on the balance of the intestinal microbiome and produced metabolites, including SCFAs. The aim of this review is to summarize what is known on the effects of probiotics on the production of short-chain fatty acids by gut microbes. In addition, the mechanism of formation and properties of these metabolites is discussed and verified test results confirming the effectiveness of probiotics in human nutrition by modulating SCFAs production by intestinal microbiome is presented.

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“…The gut microbiota composition is altered in many disease states, such as cardiovascular disease, cancer, malignancy, type 2 diabetes mellitus, obesity, colitis, asthma, psychiatric disorders, inflammatory disorders, disorders of the gut-brain axis, and numerous immune disorders [ 15 , 40 , 41 , 46 – 48 ]. Modulation of the gut microbiota facilitates a number of health problems; probiotic feeding with a high-fat diet showed alteration of the gut microbiota composition with a decrease in the gram-positive bacteria phyla Firmicutes and Actinobacteria in mice [ 49 ]. In contrast, in a mouse model of hyperlipidemia, the probiotic administration of Lactobacillus led to significant changes in the microbiota composition, including an increased abundance of Bacteroidetes and Verrucomicrobia and a reduced ratio of Firmicutes [ 50 ].…”

Section: Modulation Of Gut Microbiota and Probiotic Speciesmentioning

confidence: 99%

Probiotic Species in the Modulation of Gut Microbiota: An Overview

Azad

Sarker

et al. 2018

BioMed Research International

605

400

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Probiotics are microbial strains that are beneficial to health, and their potential has recently led to a significant increase in research interest in their use to modulate the gut microbiota. The animal gut is a complex ecosystem of host cells, microbiota, and available nutrients, and the microbiota prevents several degenerative diseases in humans and animals via immunomodulation. The gut microbiota and its influence on human nutrition, metabolism, physiology, and immunity are addressed, and several probiotic species and strains are discussed to improve the understanding of modulation of gut microbiota. This paper provides a broad review of several Lactobacillus spp., Bifidobacterium spp., and other coliform bacteria as the most promising probiotic species and their role in the prevention of degenerative diseases, such as obesity, diabetes, cancer, cardiovascular diseases, malignancy, liver disease, and inflammatory bowel disease. This review also discusses a recent study of Saccharomyces spp. in which inflammation was prevented by promotion of proinflammatory immune function via the production of short-chain fatty acids. A summary of gut microbiota alteration with future perspectives is also provided.

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Oral Administration of Compound Probiotics Ameliorates HFD-Induced Gut Microbe Dysbiosis and Chronic Metabolic Inflammation via the G Protein-Coupled Receptor 43 in Non-alcoholic Fatty Liver Disease Rats

Cited by 104 publications

References 50 publications

Sex differences in gut microbiome in high-fat-diet fed rats.

Sex differences in gut microbiome in high-fat-diet fed rats.

The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome

Probiotic Species in the Modulation of Gut Microbiota: An Overview

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