Oral administration of essential oil from Psidium glaziovianum Kiaersk leaves alleviates pain and inflammation in mice

Development of gel containing Psidium glaziovianum essential oil has in vitro antimicrobial activity and improves healing of excisional wounds in mice

“…The level of IL-1β and TNF-α was signi cantly restored by treating the animals for 14 days with PgEO gel, demonstrating remarkable improvement in in ammation with topical application. These results are consistent with previously published research using PgEO, in which IL-1β and TNF-α values decreased with oral treatment, attenuating the in ammatory condition (Costa et al, 2022). This decrease may be an effect of the presence of 1,8-cineol, as in a study carried out by Ehrnhofer-Ressler et al ( 2013), 1,8-cineol was applied on monocytes stimulated with LPS at a concentration of 1.5 µg/mL, the results revealed a considerable drop in TNF-α and IL-1β levels, with a reduction of 99 and 84%, respectively.…”

“…Regarding the yeasts, the PgEO gel presented MIC that varied from 1024 to 2048 µg/mL for the different species of Candida (Table 1). Previously, PgEO demonstrated the ability to modulate the in ammatory response (Costa et al, 2022), the composition of the essential oil and its major components, such as 1,8-cineole, α-pinene and β-pinene, which played a signi cant role in driving the anti-in ammatory activity, are probably the cause of the faster healing e ciency of PgEO-gel. Mohammed et al (2022) produced an ointment containing 1,8-cineol that accelerated the healing of burn wounds, in addition to exerting antioxidant and anti-in ammatory effects.…”

“…The essential oil was extracted from P. glaziovianum (PgEO) leaves by hidrodestilation and identi ed by gas chromatography mass spectrometry (GC/MS); the results were previously published by Costa et al (2022). It contained 48 constituents and made up 98.22% of the composition, which was dominated by 1,8-cineole (24.29%), α-pinene (19.73%), and β-pinene (17.31%).…”

“…Psidium glaziovianum Kiaersk it is a small to medium-sized tree that is found in the Caatinga and Atlantic Forests of Brazil and is thought to be an endemic species there (Landrum et al, 2017). P. glaziovianum essential oil (PgEO) was previously reported to have antinociceptive and anti-in ammatory activity as well as low oral toxicity (Costa et al, 2022(Costa et al, , 2023.…”

Essential Oil of Psidium glaziovianum Kiaersk Alleviates the Effects of Complete Freund’s Adjuvant (CFA)-Induced Arthritis by Regulating Inflammation and Oxidative Stress

“…With distribution in tropical and subtropical regions of the world, traditional populations mention the genus Psidium as a resource in folk medicine to treat various diseases related to the digestive system, such as diarrhea, stomach pains, abdominal pain, and dysentery [12][13][14][15][16][17]. In addition, this genus is also used in the treatment of disorders of the genitourinary system [18] and the respiratory system, such as sore throat [16,19].…”