Oral administration of Grifola frondosa affect lipid metabolism and insulin signaling pathway on BKS. Cg-+Lepr^db/+Lepr^db/OlaHsd mouse

Abstract

Diabetes mellitus is a carbohydrate metabolism disorder accompanied by hyperglycemia occurring when the rate of insulin secretion is insufficient because insulin synthesis is hindered or when normal functions of insulin are not carried out in the liver, fat, and muscle tissues due to insulin resistance (Park et al., 2007;Joung et al., 2017). Type 2 diabetes accounts for most of the diabetes, and South Korea is no exception. According to the International Diabetes Federation (IDF), the prevalence rates of diabetes and impaired glucose tolerance (IGT) among adults aged 20-79 years in South Korea as of 2017 were 8.84 and 13.76%, respectively, and were predicted to increase to 12.08 and 16%, respectively, by 2045, and the global prevalence rates were predicted to increase by 48%