Oral administration of octacosanol modulates the gut bacteria and protects the intestinal barrier in ulcerative colitis mice

Abstract

Ulcerative colitis (UC), belonging to chronic inflammatory bowel disease (IBD), has increasing morbidity (Pang et al., 2021), especially in the developing countries (Nascimento et al., 2020). UC is a frequently-occurring disease between the age of 30 and 40 (Armuzzi & Liguori, 2021) and is characterized by a long disease course and repeated attacks. UC patients may suffer from bloody stool and diarrhea (Armuzzi & Liguori, 2021), furthermore, UC is not only a physical disease, but also cause psychiatric disorders, such as depression, anxiety, and fatigue (Nowakowski et al., 2016). Currently, aminosalicylic acid preparations (e.g., mesalazine, sulfasalazine), corticosteroids (e.g., prednisolone), immunosuppressants, and biological agents are the most typical drugs for UC. However, the safety, efficacy, and expensive

Protective Effect of Alpinia oxyphylla Fructus Polysaccharides Extracted with Different Solvents on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice

“…Disturbance of intestinal fora can lead to an increase in F/B values [60]. Te research report proved that Octadecanol-H treatment can reduce the F/B ratio of mice, which may be related to the anti-infammatory efect of Bacteroidota [61,62]. In our study, AOFPs also presented a reduced F/B ratio and increased the relative abundance of Bacteroidota.…”

Comparison of Policosanol Profiles of the Sprouts of Wheat Mutant Lines and the Effect of Differential LED Lights on Selected Lines

“…Octacosanol (C28-OH) induces a dose-dependent activation of AMPK phosphorylation in human hepatoma HepG2 cells, suggesting it is a lipid/cholesterol-lowering agent [6,48]. In addition, new molecular mechanisms of octacosanol (C28-OH) have recently been discovered, including insulin-resistance management by the regulation of the gut microbiota and inflammatory signaling pathway [49], lipid-decreasing effects through a modulation of the lipid metabolism-related signaling pathway [50], protective effects on the integrity of the gut barrier through a modulation of the intestinal flora and its metabolism [51], and anti-fatigue effects in an exercise-induced fatigue model [52]. Therefore, mutant lines exhibiting a high octacosanol (C28-OH) accumulation could have potential applications as functional foods and promote new cultivars' development.…”

Microencapsulation improves the effects of octacosanol to ameliorate alcoholic liver injury

“…Ding et al (2023) found that gastric and intestinal fluids can degrade Oct. Our results suggested that microencapsulation could protect Oct, reducing its degradation in the stomach and allowing the release of the vast majority of Oct in the intestine. Oct can improve health by regulating the gut bacteria to exert bioactive functions, such as being utilized by gut bacteria to produce short-chain fatty acids and protect the gut barrier (Miao et al, 2022). Therefore, based on the protective effect and delivery function of Oct by microcapsules, it may promote the utilization of Oct by gut bacteria to exert more significant effects.…”