Oral administration of patchouli alcohol isolated from Pogostemonis Herba augments protection against influenza viral infection in mice

Li, Yucui; Peng, Shaozhong; Chen, Haiming; Zhang, Fengxue; Xu, Pao; Xie, Jianhui; He, Jingjin; Chen, Jiannan; Lai, Xiaoping; Su, Zi-Ren

doi:10.1016/j.intimp.2011.12.007

Cited by 63 publications

(44 citation statements)

References 37 publications

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“…The dose of influenza virus used to induce infection was performed as described previously [27]. The challenge inoculation of approximately 10 5.0 cell culture infectious doses (CCID 50 )/mouse equated to five 50 % mouse lethal challenge doses (MLD 50 ).…”

Section: Murine Model Of Influenza Infectionmentioning

confidence: 99%

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1, 8-Cineol Protect Against Influenza-Virus-Induced Pneumonia in Mice

Lai

Wang

et al. 2016

Inflammation

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1,8-Cineol is a major monoterpene principally from eucalyptus essential oils and has been shown to exert anti-inflammatory, antiviral, and inhibitory of nuclear factor (NF)-kB effect. In the present study, we evaluated the effect of 1,8-cineol on mice infected with influenza A virus. We found that 1,8-cineol protects against influenza viral infection in mice. Moreover, 1,8-cineol efficiently decreased the level of IL-4, IL-5, IL-10, and MCP-1 in nasal lavage fluids and the level of IL-1β, IL-6, TNF-α, and IFN-γ in lung tissues of mice infected with influenza virus. The results also showed that 1,8-cineol reduced the expression of NF-kB p65, intercellular adhesion molecule (ICAM)-1, and vascular cell adhesion molecule (VCAM)-1 in lung tissues. Thus, 1,8-cineol appears to be able to augment protection against IFV infection in mice via attenuation of pulmonary inflammatory responses.

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Section: Murine Model Of Influenza Infectionmentioning

confidence: 99%

“…The viral load in the lungs was determined as previously described [27]. The lungs were homogenized and centrifuged at 4000×g for 15 min at 4°C.…”

Section: Viral Load Analysismentioning

confidence: 99%

1, 8-Cineol Protect Against Influenza-Virus-Induced Pneumonia in Mice

Lai

Wang

et al. 2016

Inflammation

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“…The histological changes were observed and recorded under a microscope by a pathologist who was blind to the grouping (Li et al , 2012Lin et al 2012;Pugh et al 2015).…”

Section: Lung Histopathology Examinationmentioning

confidence: 99%

Protective effects of phillyrin against influenza A virus in vivo

Liu

Zhang

et al. 2016

Arch. Pharm. Res.

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Influenza A virus infection represents a great threat to public health. However, owing to side effects and the emergence of resistant virus strains, the use of currently available anti-influenza drugs may be limited. In order to identify novel anti-influenza drugs, we investigated the antiviral effects of phillyrin against influenza A virus infection in vivo. The mean survival time, lung index, viral titers, influenza hemagglutinin (HA) protein and serum cytokines levels, and histopathological changes in lung tissue were examined. Administration of phillyrin at a dose of 20 mg/kg/day for 3 days significantly prolonged the mean survival time, reduced the lung index, decreased the virus titers and interleukin-6 levels, reduced the expression of HA, and attenuated lung tissue damage in mice infected with influenza A virus. Taken together, these data showed that phillyrin had potential protective effects against infection caused by influenza A virus.

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“…In silico analysis of alpha-patchouli alcohol isomers showed that alpha-Patchouli alcohol compounds (CID442384, CID6432585, CID3080622, CID10955174, and CID56928117) was suggested as a candidate for a selective COX-1 inhibitor and CID521903 as nonselective COX-1 / COX-2 (4). In-vitro analysis of alpha-patchouli alcohol had increase protection against influenza virus infection in mice by increasing the immune response, and attenuation of the systemic inflammatory response (5). Invivo analysis of alpha-patchouli alcohol also had the effect of anti-inflammatory activity, by regulating the mRNA expression of the panel of inflammatory mediators, including TNF-α, IL-1β, iNOS and COX-2 (6).…”

Section: Introductionmentioning

confidence: 97%

Molecular Dynamic Screening Sesquiterpenoid Pogostemon Herba as Suggested Cyclooxygenase Inhibitor

Kikuchi¹

2016

Acta Inform Med

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Objective: Virtual molecular dynamic sesquiterpenoid Pogostemon Herba (CID56928117, CID94275, CID107152, and CID519743) have screening as cyclooxygenase (COX-1/ COX-2) selective inhibitor. Methods: Molecular interaction studies sesquiterpenoid compounds with COX-1 and COX-2 were using the molecular docking tools by Hex 8.0 and interactions were further visualized using by Discovery Studio Client 3.5 software tool and Virtual Molecular Dynamic 1.9.1 software. The binding energy calculation of molecular dynamic interaction was calculated by AMBER12 software. Result: The analysis of the sesquiterpenoid compounds showed that CID56928117, CID94275, CID107152, and CID519743 have suggested as inhibitor of COX-1 and COX-2. Conclusion: Collectively, the scoring binding energy calculation (with PBSA Model Solvent) sesquiterpenoid compounds: CID519743 had suggested as candidate for non-selective inhibitor; CID56928117 and CID94275 had suggested as candidate for a selective COX-1 inhibitor; and CID107152 had suggested as candidate for a selective COX-2 inhibitor.

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Oral administration of patchouli alcohol isolated from Pogostemonis Herba augments protection against influenza viral infection in mice

Cited by 63 publications

References 37 publications

1, 8-Cineol Protect Against Influenza-Virus-Induced Pneumonia in Mice

1, 8-Cineol Protect Against Influenza-Virus-Induced Pneumonia in Mice

Protective effects of phillyrin against influenza A virus in vivo

Molecular Dynamic Screening Sesquiterpenoid Pogostemon Herba as Suggested Cyclooxygenase Inhibitor

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