Oral Administration of Quercetin or Its Derivatives Inhibit Bone Loss in Animal Model of Osteoporosis

Abstract

Objectives. Quercetin (Q) and its derivatives are the major members of the naturally occurring flavonoid family, which possess beneficial effects on disease prevention including osteoporosis. The present study is aimed at further investigating the efficacy of the Q and its derivatives on bone pathology, bone-related parameters under imageology, bone maximum load, and serum bone metabolism indexes in animal model of osteoporosis. Potential mechanisms of Q and its derivatives in the treatment of osteoporosis as well as the existing problems regarding the modeling method and limitations of researches in this area were also summarized. Eight databases were searched from their inception dates to February 2020. Nineteen eligible studies containing 21 comparisons were identified ultimately. The risk of bias and data on outcome measures were analyzed by the CAMARADES 10-item checklist and Rev-Man 5.3 software separately. The results displayed the number of criteria met varied from 3/10 to 7/10 with an average of 5.05. The present study provided the preliminary preclinical evidence that oral administration of Q or its derivatives was capable of improving bone pathology, bone-related parameters under imageology and bone maximum load, increasing serum osteocalcin, alkaline phosphatase, and estradiol, and reducing serum c-terminal cross-linked telopeptide of type I collagen ( P < 0.05 ). No statistical difference was seen in survival rate, index of liver, or kidney function ( P > 0.05 ). Q and its derivatives partially reverse osteopenia probably via antioxidant, anti-inflammatory, promoting osteogenesis, inhibiting osteoclasts, and its estrogen-like effect. The findings reveal the possibility of developing Q or its derivatives as a drug or an ingredient in diet for clinical treatment of osteoporosis.

Network Pharmacology and Molecular Docking Elucidate the Pharmacological Mechanism of the OSTEOWONDER Capsule for Treating Osteoporosis

“…Quercetin is one of the members of the naturally occurring flavonoid family, and is well known for its anti-oxidant, anti-inflammatory, and anti-tumor properties ( Eid and Haddad, 2017 ; Tang et al, 2020 ). Surprisingly, quercetin exerts anti-OP by promoting osteogenic differentiation, anti-oxidant response, and anti-inflammatory properties ( Wang et al, 2017 ; Yuan et al, 2018 ; Huang et al, 2020 ; Oh et al, 2020 ; Wang et al, 2021 ). Here, we found that quercetin has been used as an agent for OP by reducing EGFR, HIF1A, and IL6 expression.…”

Quercetin promotes osteogenic differentiation and antioxidant responses of mouse bone mesenchymal stem cells through activation of the AMPK/SIRT1 signaling pathway

“…In fact, increasing research has focused on the possible consequences of quercetin stimulation in BMSCs. For example, Huang et al found oral administration of quercetin or its derivatives inhibited bone loss in animal model of osteoporosis (Huang et al, 2020). Zhou et al reported that quercetin promoted the osteogenic differentiation and angiogenic factor expression of BMSCs.…”

Potential Implications of Quercetin in Autoimmune Diseases

“…The polyphenol quercetin (3,3′,4′,5,7-pentahydroxyflavone) is a dietary flavonoid that is commonly found in vegetables (asparagus), fruits (apples, capers, chokeberries, cranberries), and medicinal herbs including lovage, dill, cilantro, and radish leaves (4)(5)(6). Many previous studies have shown that appropriate doses of quercetin have a variety of biological activities and neuroprotective, antiallergic, anti-oxidant, anti-inflammatory, immunomodulatory, anti-microbial, and anti-tumor effects (7)(8)(9)(10)(11)(12). Various ongoing scientific studies are investigating the use of natural products to develop drugs to treat autoimmune diseases.…”