Oral Alitretinoin (9-cis-Retinoic Acid) Therapy for Chronic Hand Dermatitis in Patients Refractory to Standard Therapy

Ruzicka, Thomas; Larsen, Finn Breinholt; Galewicz, Dorota; Horváth, Attila; Coenraads, P.J.; Thestrup‐Pedersen, Kristian; Ortonne, Jean Paul; Zouboulis, Christos C.; Harsch, Martin; Brown, Thomas C.; Zultak, M

doi:10.1001/archderm.140.12.1453

Cited by 129 publications

(148 citation statements)

References 18 publications

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“…Analogues of vitamin A and D are attractive therapeutical agents in many skin diseases due to their action on both epidermal and inflammatory components of skin lesions [1,2] . Vitamin D is both a vitamin and a hormone and has a significant role in the maintenance of calcium and phosphor homeostasis.…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative Effect of Vitamin A and D Analogues on Adult Human Keratinocytes in vitro

Popadić

Ramić²,

Medenica³

et al. 2008

Skin Pharmacol Physiol

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Background: Vitamin A and D analogues play an important role in epidermal homeostasis and are used in the treatment of various skin diseases. The failure of retinoid and vitamin D treatments is sometimes difficult to explain. Methods: We analyzed the effect of all-trans retinoic acid (all-trans RA), 13-cis retinoic acid (13-cis RA), ergocalciferol and cholecalciferol in keratinocyte cultures established from adult donors, on the cell proliferation by means of [³H]thymidine incorporation and apoptosis after fluorescein diacetate/trypan blue staining. Results: All tested agents exerted a dose-dependent inhibition of keratinocyte proliferation in the concentration range of 1.25–5 µM. Based on IC₅₀ values, the antiproliferative efficiency was as follows: cholecalciferol > ergocalciferol = all-trans RA > 13-cis RA. The observed effect of cholecalciferol and ergocalciferol, but not retinoids, involved the induction of apoptotic cell death. Combining vitamins A and D did not further increase the proliferation block and even displayed an antagonistic effect. Conclusion: The susceptibility of keratinocytes to the antiproliferative action of vitamins A and D was markedly different in cell cultures derived from different donors, indicating a possible predictive value of the in vitro testing for the efficiency of the clinical response to these agents.

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Section: Introductionmentioning

confidence: 99%

Antiproliferative Effect of Vitamin A and D Analogues on Adult Human Keratinocytes in vitro

Popadić

Ramić²,

Medenica³

et al. 2008

Skin Pharmacol Physiol

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show abstract

“…9 Most had hyperkeratotic eczema (82 per cent), fingertip eczema (28 per cent) and/or pompholyx (23 per cent). The aetiology of eczema was unknown in 45 per cent of patients; the remainder were equally divided between allergic and irritant causes.…”

Section: Efficacymentioning

confidence: 99%

Alitretinoin (Toctino): new oral retinoid for chronic hand eczema

English¹

2009

Prescriber

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“…14,15 RA, a derivative of vitamin A, is extensively used for the treatment of acute promyelocytic leukemia 16 and dermatological conditions. 17 Studies involving RA use in these conditions have shown that high doses of RA can induce the potentially fatal reaction retinoic acid syndrome [18][19][20] as well as complications such…”

Section: Development Of a Nanoparticulate Formulation Of Retinoic Acimentioning

confidence: 99%

Development of a nanoparticulate formulation of retinoic acid that suppresses Th17 cells and upregulates regulatory T cells

Capurso

Look

Jeanbart³

et al. 2010

Self/Nonself

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Oral Alitretinoin (9-cis-Retinoic Acid) Therapy for Chronic Hand Dermatitis in Patients Refractory to Standard Therapy

Cited by 129 publications

References 18 publications

Antiproliferative Effect of Vitamin A and D Analogues on Adult Human Keratinocytes in vitro

Antiproliferative Effect of Vitamin A and D Analogues on Adult Human Keratinocytes in vitro

Alitretinoin (Toctino): new oral retinoid for chronic hand eczema

Development of a nanoparticulate formulation of retinoic acid that suppresses Th17 cells and upregulates regulatory T cells

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