Oral Alveolar Soft Part Sarcoma in Childhood and Adolescence: Report of Two Cases and Review of Literature

Argyris, Prokopios P.; Reed, Robyn C.; López‐Terrada, Dolores; Jakacky, Jared; Cayci, Zuzan; Tosios, Konstantinos I.; Pambuccian, Stefan E.; Thompson, Lester D.�R.; Koutlas, Ioannis G.

doi:10.1007/s12105-012-0395-y

Cited by 32 publications

(37 citation statements)

References 48 publications

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“…Lieberman et al reviewed the clinical and histopathological features of 102 cases of ASPS. In their study, the median age at diagnosis was 22 years (range 2–71 years) and the female-to-male ratio was 1.5:1, with a higher female-to-male ratio in childhood and adolescence 8. In accordance with the above facts, the patient who reported to our department was a 35-year-old woman with a swelling in the lower right side limb.…”

Section: Discussionsupporting

confidence: 61%

Alveolar soft part sarcoma

et al. 2014

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SUMMARYAlveolar soft part sarcoma (ASPS) is a rare form of soft tissue sarcoma and is most often seen in adolescents and young adults. Despite its unique histology and wellcharacterised genetic translocation, many questions remain regarding the pathogenesis and treatment of this tumour type. Surgical excision of the primary tumour and pulmonary metastases has resulted in prolonged survival of some patients while the benefit of adjuvant chemotherapy and/or radiotherapy has been disputed. A 35-year-old woman presented with a tumour in the right leg and right side of the mandible along with active metastasis to lungs and multiple skeletal sites. BACKGROUND

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Section: Discussionsupporting

confidence: 61%

Alveolar soft part sarcoma

et al. 2014

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“…In the head and neck region typical sites include the tongue and orbit, with other sites being very rare [ 2 – 4 , 6 – 8 ]. It primarily affects adolescents and young adults (between the ages 15 and 35) and has a predilection for females over males [ 5 – 8 ]. Though they are relatively indolent in nature, due to their high rates of late-onset metastasis, they typically have a poor long-term prognosis [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Adult Alveolar Soft Part Sarcoma of the Head and Neck: A Report of Two Cases and Literature Review

Mullins

Hackman

2014

Case Reports in Oncological Medicine

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Background. Alveolar soft part sarcomas (ASPS) of the head and neck are rare, aggressive soft-tissue malignancies. This study describes the clinical course and management of two patients presenting with ASPS in very rare head and neck locations, the larynx and parotid gland. Methods. We identified two patients presenting with ASPS of the head and neck and treated at the University of North Carolina. We compared our results to the literature from 1987 to 2013. Results. Patient ages at diagnosis were 27 and 39 with presenting symptoms of hoarseness and parotid swelling, respectively. Mean follow-up was 87 months. All patients received surgical resection and adjuvant radiotherapy. There were no recurrences or evidence of distant metastatic spread during the series. Disease-free survival time for the patients was 4 months and 168 months, respectively. Conclusions. Our study suggests that a combined-modality approach is important in the treatment of ASPS of the head and neck even in these rare locations. Continued research into new therapies is necessary to improve historically poor outcomes.

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“…Among the lingual cases, in 8 and 7 of the cases, the dorsal surface and the base of the tongue were affected, respectively, but precise location was not available in 17 cases. [7] Base of the tongue was the location in Case 1 of oral cavity and hence was clinically opined to be a ranula.…”

Section: Discussionmentioning

confidence: 99%

Alveolar soft part sarcoma in childhood: A report of two cases and review of literature

Chatura¹,

Doradla²,

Kusagur³

2017

JCRI

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Background: Alveolar soft part sarcoma (ASPS) is a rare, distinctive soft tissue sarcoma, typically occurring in young people. In children, a substantial percentage of cases occur in the head and neck, often in the orbit or tongue. Although it displays a relatively indolent clinical course, the ultimate prognosis is poor with late metastases. Aims and Objectives: Review of literature to give an insight into the current knowledge about this enigmatic tumor, in terms of genetic and diagnostic aspects. Materials and Methods: Clinical, radiological, and morphological features of two cases, an 8-year-old female with tongue lesion and a 14-year-old female with orbital lesion are described. Immunohistochemistry (IHC) with a panel of antibodies was performed. Results: Clinical presentation and microscopic features were remarkable in two young females, one in the tongue and another in the orbit and similar to other case reports. The use of TFE3 for IHC established the diagnosis. Conclusion: Alveolar soft-part sarcoma remains an enigma clinically. ASPS should be considered in the differential diagnosis of pediatric head and neck masses with a solid morphology.

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Oral Alveolar Soft Part Sarcoma in Childhood and Adolescence: Report of Two Cases and Review of Literature

Cited by 32 publications

References 48 publications

Alveolar soft part sarcoma

Alveolar soft part sarcoma

Adult Alveolar Soft Part Sarcoma of the Head and Neck: A Report of Two Cases and Literature Review

Alveolar soft part sarcoma in childhood: A report of two cases and review of literature

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