Oral and dental adverse drug reactions

Seymour, R. A.; Rudralingham, Meenakshi

doi:10.1111/j.1600-0757.2008.00226.x

Cited by 26 publications

(28 citation statements)

References 87 publications

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“…7 These adverse reactions depend on the drug and its pharmacodynamics and pharmacokinetics, as well as any individual variability in drug metabolism. 8 Multiple pathologic mechanisms are responsible for drug induced pigmentation disorders. Comparing with immunological etiology underlying many drug allergies, most cases of pharmacologic pigmentation are not immunologically mediated.…”

Section: Discussionmentioning

confidence: 99%

Drugs Causing Orofacial Pigmentation: An Overview of Literature

Hasan¹,

Khan²,

Sherwani³

et al. 2013

Int. Res. J. Pharm.

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The term "Oro-facial pigmentation" refers to a wide range of lesions or conditions featuring a change of color of Oro-facial tissues. Pigmentation of the Orofacial tissues is seen in certain races or ethnic groups such as Indians, Africans and Europeans. Broadly classifying, Oro-facial pigmentation is divided into endogenous pigmentation and exogenous pigmentation. Endogenous pigmentation is due to pigments produced within the body. Exogenous pigmentation occurs when foreign bodies get impregnated into the oral mucosa and appear as localized area of altered pigmentation. Drug constitutes an important endogenous cause of Oro-facial pigmentation. Hereby, we are presenting an overview of various drugs in the etio-pathogenesis of Oro-facial pigmentation.

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Section: Discussionmentioning

confidence: 99%

Drugs Causing Orofacial Pigmentation: An Overview of Literature

Hasan¹,

Khan²,

Sherwani³

et al. 2013

Int. Res. J. Pharm.

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“…These adverse reactions depend on the drug and its pharmacodynamics and pharmacokinetics, as well as any individual variability in drug metabolism [6]. Pigmentary changes in the oral mucosa are caused by many medications, including anti-malarial drugs (chloroquine phosphate, hydroxychloroquine, quinidine, and quinacrine), tranquilizers (chlorpromazine), chemotherapeutics (doxorubicin, busulfan, and cyclophosphamide), anti-retroviral agents (zidovudine, AZT, and ketoconazole), antibiotics (minocycline), and laxatives (phenolphthalein) [1].…”

Section: Discussionmentioning

confidence: 99%

“…A dental surgeon must be aware of the many adverse reactions and side effects from medications that can compromise the oral tissues in order to identify them and treat them, as well as prevent them whenever possible [6]. Important factors to consider in the differential diagnosis include the site and color of the lesion, changes in pigmentation over time, family medical history, and medication use including duration [3].…”

Section: Discussionmentioning

confidence: 99%

Palate Hyperpigmentation Caused by Prolonged Use of the Anti-Malarial Chloroquine

Filho

Silva

Dourado

et al. 2011

Head and Neck Pathol

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The side-effects of many drugs manifest in the oral mucosa. The anti-malarial agent chloroquine diphosphate, which is also used to treat immunological, dermatological, and rheumatological disorders, usually causes pigmentary changes in the oral mucosa. This report presents a case of palate pigmentation related to the prolonged use of chloroquine diphosphate caused by the deposition of drug metabolites in the mucosa. Healthcare professionals must be aware of these drugs and their adverse effects in order to make the correct diagnosis, decide on the optimal treatment for the condition, or refer the patient to an appropriate specialist.

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“…Developing body tissues may be effected by certain drugs, if given during pregnancy. Oral and dental structures are frequently the sites of adverse drug reactions (Seymour & Rudralingham, 2008). Almost every pregnant woman is exposed to some type of medication during pregnancy (Buhimschi & Weiner, 2009).…”

Section: Introductionmentioning

confidence: 99%

Micro Hardness of Dental Tissues Influenced by Administration of Aspirin During Pregnancy

2015

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SHAKILA, N.; ALI, A. & ZAIDI, S.Micro hardness of dental tissues influenced by administration of aspirin during pregnancy. Int. J. Morphol., 33(2):586-593, 2015. SUMMARY:The study is associated with the effect of aspirin (Acetyl Salicylic Acid) on the microhardness of mineralized tissues of the offspring's teeth, in response to the ingestion of the drug during pregnancy. Aspirin is a widely used analgesic and antipyretic medicine, for symptomatic treatment. Misuse of this drug during pregnancy may instigate developmental defects in offspring. An experimental control study was designed, in which female rabbits were taken as representative mammalian models and treated with aspirin during pregnancy. Their offspring's teeth were used to assess the microhardness of dental tissues. The rabbits were alienated into two groups, treated and control, consisting of seven rabbits in each set (n= 7). Microhardness was evaluated in three types of the sample teeth. The total number of teeth examined were, 2x7x12= 168 samples. Vicker's Hardness degree values were measured and recorded vis-à-vis (50 g for 15 s with 3 indentations per specimen on enamel and dentine separately). The range of hardness obtained was statistically analyzed and the Student's t-tests was applied, with the aid of SPSS version 20. The P-values for both enamel and dentine from maxillary incisors and molars were less than 0.05. The same trend was observed in the mandibular teeth. However, a teratogenicity of Acetyl Salicylic Acid was pragmatic in the recent in vivo studies. Based on the analysis, it was evident that the aspirin administration could produce negative effects leading to reduction in the microhardness of dental tissues of the offsprings.

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Oral and dental adverse drug reactions

Cited by 26 publications

References 87 publications

Drugs Causing Orofacial Pigmentation: An Overview of Literature

Drugs Causing Orofacial Pigmentation: An Overview of Literature

Palate Hyperpigmentation Caused by Prolonged Use of the Anti-Malarial Chloroquine

Micro Hardness of Dental Tissues Influenced by Administration of Aspirin During Pregnancy

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