Oral and gastrointestinal symptomatic metastases as initial presentation of lung cancer

Jeba, Jenifer; Backianathan, Selvamani; Ishitha, Gunadala; Singh, Ashish

doi:10.1136/bcr-2016-217539

Cited by 8 publications

(16 citation statements)

References 14 publications

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“…[ 6 ] Primary NSCLC spreads to distant organs by 3 routes: systemic, venous, or lymphatic circulation. [ 2 ] Lingual metastases occur mostly in patients whose primary lung cancers are generally disseminated; their prognoses tend to be rather poor (Table 2 ). This patient's rare tongue metastasis likely occurred through lymphatic circulation rather than systemic or venous dissemination, as his PET-CT showed there was no widespread metastasis to other sites.…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 ] Distant metastasis from primary lung cancer—e.g., to brain, liver, adrenals, or bone—is quite common; however, metastases to the tongue are relatively rare. [ 2 ] In a previous report, primary lung cancer metastasized to the tongue was found in 1.6% of 3047 cases. [ 3 ] About 5% of all malignant lesions were found in the oral cavity, [ 4 ] and 1% of them were from primary sites other than the oral cavity.…”

Section: Introductionmentioning

confidence: 99%

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A case report of tongue metastasis from lung squamous cell carcinoma and literature review

Cheng

Hu²,

Han³

et al. 2017

Medicine

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Rationale:Tongue metastasis from lung cancer is extremely rare, and the prognosis of these patients is rather poor.Patient concers:A 56-year-old man was found a 4-cm cavity lesion in the left upper lobe, which was initially misdiagnosed as tuberculosis.Diagnoses:A case of lung squamous cell carcinoma that metastasized to the base of a patient's tongue.Intervations:We send the biopsy of the lung and the tongue lesions for gene sequencing.Outcomes:He received systemic chemotherapy, but continued to have pain at the base of his tongue and died 7 months later.Lessons:From sequencing data, mutations in KRAS proto-oncogene, GTPase (KRAS), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), and tumor protein p53 (TP53) were found in the tumor biopsy of the patient. All of these were indicators of poor prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A case report of tongue metastasis from lung squamous cell carcinoma and literature review

Cheng

Hu²,

Han³

et al. 2017

Medicine

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“…The route by which lung cancer metastasizes to the gastrointestinal tract is currently unknown, but both hematogenous and lymphatic routes are considered to be involved ( 4 , 5 , 12 ). The patient in the present case report had diabetes, which could block the immunological surveillance of cancer cells and may cause unusual metastases ( 16 ). However, there are several limitations to this report.…”

Section: Discussionmentioning

confidence: 95%

Gastrointestinal hemorrhage caused by duodenal metastasis from a primary lung adenocarcinoma: A case report

et al. 2021

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The present case study reported a rare case of duodenal metastasis from a lung adenocarcinoma. A 62-year-old male, who underwent radical lung cancer surgery two years ago, was readmitted to Guangzhou Red Cross Hospital complaining of epigastric pain. The esophagogastroduodenoscopy identified a 2.5x3.5 cm ulcerative lesion at the duodenum. Histopathological and immunohistochemical staining results confirmed that the lung adenocarcinoma had metastasized to the duodenum. The tumor cells were positive for cytokeratin-7, thyroid transcription factor-1 and napsin-A expression, but negative for caudal-related homeobox 2 expression. Prior to the second cycle of targeted treatment with anlotinib, the patient reported severe hematochezia. Therefore, an angiography and artery embolization were subsequently performed. However, the patient succumbed to acute kidney injury three days after the operation. The metastasis of lung cancer to the gastrointestinal tract is extremely rare and usually asymptomatic. However, when treating patients with lung cancer presenting with digestive symptoms or other distant metastatic sites, clinicians should consider the possibility of gastrointestinal metastasis so that it can be identified in a timely manner. If lesions exist, doctors should locate these and perform biopsies to conduct histopathological and immunohistochemical examinations to make a clear diagnosis.

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“… 1 The prevalence of small bowel metastases from lung cancer ranges between 2.6% and 10.7%, and most were found incidentally at autopsy examination in patients with advanced or widely disseminated lung cancer. 4 Although any tumour cell type of lung cancer can develop gastrointestinal metastases, the most common type is a squamous cell, followed by a large cell, and then adenocarcinoma. 5 Among small bowel metastasis, the jejunum is the most frequent site of involvement (50.9%), followed by the ileum (33.3%) and the duodenum (15.8%).…”

Section: Discussionmentioning

confidence: 99%

Upper gastrointestinal haemorrhage caused by duodenal metastasis from primary lung cancer: A case report

Jellali

Chaouch

Jabra

et al. 2023

Respirology Case Reports

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Duodenal metastases from primary lung carcinoma are uncommon. They usually occur in terminal‐stage disease. Bleeding, as the first presentation of duodenal metastases, is rare. This case reports a rare mechanism of upper gastrointestinal bleeding due to a metastatic involvement of the duodenum and gastroduodenal artery. A 58‐year‐old man with a past medical history of pulmonary carcinoma presented an episode of hematemesis of great abundance with melena. On physical examination, he was afebrile and pale. The biological data found an anaemia with haemoglobin at 6 g/dL. The upper gastrointestinal endoscopy revealed a congestive duodenal lesion with signs of recent bleeding. An angio CT scan localized the bleeding from the gastroduodenal artery. A few hours later, the patient presented a recurrent episode of hematemesis with deglobalization. So we performed a radiologic embolization of the gastroduodenal artery. Haemorrhage as the first presentation of small bowel metastases is rare, especially when these are located in the duodenum, with a poor prognosis. Radiological embolisation could be the best choice for treatment.

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Oral and gastrointestinal symptomatic metastases as initial presentation of lung cancer

Cited by 8 publications

References 14 publications

A case report of tongue metastasis from lung squamous cell carcinoma and literature review

A case report of tongue metastasis from lung squamous cell carcinoma and literature review

Gastrointestinal hemorrhage caused by duodenal metastasis from a primary lung adenocarcinoma: A case report

Upper gastrointestinal haemorrhage caused by duodenal metastasis from primary lung cancer: A case report

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