Oral and intestinal digestion of oligosaccharides as potential sweeteners: A systematic evaluation

Hodoniczky, Jason; Morris, Carol A.; Rae, Andrew

doi:10.1016/j.foodchem.2011.12.031

Cited by 45 publications

(41 citation statements)

References 31 publications

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“…Among these various reaction patterns, there is a very unique biocatalytic property expected from this enzyme that produces sucrose isomers, turanose, and trehalulose, by using fructose as a receptor molecule (Wang et al, 2012). Turanose naturally exists as a rare disaccharide in bee honey (Buchholz et al, 1998), and has approximately 50% of the sweetness of sucrose (Shibuya et al, 2004), and this sugar showed beneficial health effects of non-carcinogenicity, low-calorigenicity, and anti-obesity (Hodoniczky et al, 2012;Park et al, 2016). With these prospective uses for turanose as a novel food material, a few studies have recently investigated the bioprocesses and optimization for mass production of turanose (Park et al, 2016).…”

Section: Sucrose Isomer Producing Reactions Of Microbial Assmentioning

confidence: 99%

Versatile biotechnological applications of amylosucrase, a novel glucosyltransferase

Seo

Yoo

Choi

et al. 2020

Food Sci Biotechnol

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Amylosucrase (AS; EC 2.4.1.4) is an enzyme that has great potential in the biotechnology and food industries, due to its multifunctional enzyme activities. It can synthesize a-1,4-glucans, like amylose, from sucrose as a sole substrate, but importantly, it can also utilize various other molecules as acceptors. In addition, AS produces sucrose isomers such as turanose and trehalulose. It also efficiently synthesizes modified starch with increased ratios of slow digestive starch and resistant starch, and glucosylated functional compounds with increased water solubility and stability. Furthermore, AS produces turnaose more efficiently than other carbohydrate-active enzymes. Amylose synthesized by AS forms microparticles and these can be utilized as biocompatible materials with various bio-applications, including drug delivery, chromatography, and bioanalytical sciences. This review not only compares the gene and enzyme characteristics of microbial AS, studied to date, but also focuses on the applications of AS in the biotechnology and food industries.

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Section: Sucrose Isomer Producing Reactions Of Microbial Assmentioning

confidence: 99%

Versatile biotechnological applications of amylosucrase, a novel glucosyltransferase

Seo

Yoo

Choi

et al. 2020

Food Sci Biotechnol

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“…Hydrolysis of turanose by rat intestinal enzymes was also reported, with a 54% rate achieved for sucrose at a 5 mM concentration level. 29 However, in vivo studies are required to more fully characterize the absorption rate and metabolism of turanose. The absorption and metabolism of another sucrose isomer, isomaltulose, have been characterized with carbohydrate load tests and [ 14 C] isomaltulose-radioisotope labeling tests in rats and humans, respectively.…”

Section: Discussionmentioning

confidence: 99%

Regulation of Inflammation by Sucrose Isomer, Turanose, in Raw 264.7 Cells

Chung

Kim

et al. 2017

J Cancer Prev

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Increased sugar consumption has been proposed to be a risk factor for obesity-related metabolic disorders. The objective of this study was to investigate the anti-inflammatory effect of turanose in Raw 264.7 macrophages. Turanose (3-O-α-D-glucosyl-D-fructose), an isomer of sucrose, naturally exists in honey. For these studies, macrophages were treated with total glucose (Glu), 50% Glu/50% turanose (T50), 25% Glu/75% turanose (T75), and 100% turanose (T100), each with a total concentration of 25 mM in cell media. Expressions of inflammatory enzymes and cytokines were analyzed. Cell viability was not affected in the turanose treated groups compared to the Glu group. Lipopolysaccharide and glucose-induced nitric oxide production, protein expression of inducible nitric oxide synthase, COX-2, and superoxide dismutase 2, and mRNA expression levels of interleukin (IL)-1β and IL-18 were significantly suppressed by turanose treatment. These results demonstrate that turanose exerts anti-inflammatory effects in vitro, and possesses potential to serve therapeutic functional sweetener for testing in vivo and in clinical trials.

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“…For instance, Gu et al (Gu et al 2003) observed an increase of reproduction of Bifidobacterium and Lactobacillus and an inhibition of growth of Clostridium perfringens after ingestion of IMOs in mice and humans. However, other studies have shown that IMOs are hydrolyzed at least partially by mammalian digestive enzymes before they reach the colon (Hodoniczky, Morris, and Rae 2012;Kohmoto et al 1992;Tsunehiro et al 1999). More specifically, in vitro studies using mammalian brush border intestinal enzymes showed that glucose disaccharides containing (a1!6), (a1!4), (a1!2) and (a1!3) are digested by the different small intestine mucosal a-glucosidases (Lin, Lee, and Chang 2016).…”

Section: Isomaltooligosaccharides (Imos)mentioning

confidence: 99%

Synthesis of novel α-glucans with potential health benefits through controlled glucose release in the human gastrointestinal tract

Gangoiti

Corwin

Lamothe

et al. 2018

Critical Reviews in Food Science and Nutrition

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The glycemic carbohydrates we consume are currently viewed in an unfavorable light in both the consumer and medical research worlds. In significant part, these carbohydrates, mainly starch and sucrose, are looked upon negatively due to their rapid and abrupt glucose delivery to the body which causes a high glycemic response. However, dietary carbohydrates which are digested and release glucose in a slow manner are recognized as providing health benefits. Slow digestion of glycemic carbohydrates can be caused by several factors, including food matrix effect which impedes a-amylase access to substrate, or partial inhibition by plant secondary metabolites such as phenolic compounds. Differences in digestion rate of these carbohydrates may also be due to their specific structures (e.g. variations in degree of branching and/or glycosidic linkages present). In recent years, much has been learned about the synthesis and digestion kinetics of novel a-glucans (i.e. small oligosaccharides or larger polysaccharides based on glucose units linked in different positions by a-bonds). It is the synthesis and digestion of such structures that is the subject of this review.

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Oral and intestinal digestion of oligosaccharides as potential sweeteners: A systematic evaluation

Cited by 45 publications

References 31 publications

Versatile biotechnological applications of amylosucrase, a novel glucosyltransferase

Versatile biotechnological applications of amylosucrase, a novel glucosyltransferase

Regulation of Inflammation by Sucrose Isomer, Turanose, in Raw 264.7 Cells

Synthesis of novel α-glucans with potential health benefits through controlled glucose release in the human gastrointestinal tract

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