Oral and Oropharyngeal Cancers and Possible Risk Factors Across Gulf Cooperation Council Countries: A Systematic Review

Al-Qahtani, Wedad Saeed; Almufareh, Nawaf Abdulrahman; AL-Johani, Halah A; Alotaibi, Rasil Khaled; Juliana, Consul Iworikumo; Aljarba, Nada H.; Alqahtani, Abdulqader Saeed; Almarshedy, Bandary; Elasbali, Abdelbaset Mohamed; Ahmed, Hussain Gadelkarim; Almutlaq, Bassam Ahmed

doi:10.14740/wjon1283

Cited by 19 publications

(21 citation statements)

References 53 publications

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“…use of smokeless tobacco, alcohol, diet and poor oral hygiene. Saudi Arabia reported a high malignancy index, revealing 36.1% of Squamous Cell Carcinomas, 12,13 Moreover, this Saudi research article presented most outcomes to be neoplasia of the malignant category (38.7%) rather than inflammatory (16.5%) or reactive lesions. 12 Evaluating biopsies done in another university hospital in Pakistan painted a similar picture of rising trends of malignant outcomes.…”

Section: Discussionmentioning

confidence: 73%

Histopathological Outcome of Oral Lesions in Pakistani Population with Special Emphasis on Oral Cancer

Waheed

Sarfraz

Kaleem

et al. 2022

PAFMJ

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Objective: To evaluate varying histopathological outcomes of oral lesions in different age groups and locations of the lesions, with special emphasis on oral cancer. Study Design: Cross-sectional study. Place and Duration of Study: Histopathology Department, Foundation University Medical College Islamabad Pakistan, from May 2019 to May 2021. Methodology: A total of 99 cases of oral lesions which were biopsied and were adequate in size were included in the study. Biopsies were evaluated histologically for non-neoplastic, neoplastic and premalignant lesions about age, nature and location of the lesions. Data collection was through Medix Online Histopathology Reporting System (MOHRS). Results: A total of 99 cases were included in the study, out of which 41 cases (41.4%) were non-neoplastic, 56 cases (56.6%) were neoplastic, and 2 cases (2.0%) were premalignant lesions. Out of 41 non-neoplastic lesions, the majority were inflammatory (14 cases), followed by fibroepithelial polyps (5 cases), pyogenic granulomas (4 cases), and hyperplasia (3 cases). Out of 56 neoplastic lesions, 39 (69.6%) were confirmed as carcinomas, squamous cell carcinoma being the most common malignancy in 29 cases (74.3%), followed by verrucous carcinoma in 5 cases (12.8%). In addition, there were two cases (11.7%) of potentially premalignant lesions. Buccal mucosa and tongue were more predominant sites of oral pathologies than other sites. Conclusion: In our setup, most of the oral lesions evaluated histologically turn out to be neoplastic and that too malignant, mostly squamous cell carcinomas. Most of the oral lesions occur in the fifth and sixth decade. Buccal mucosa and tongue.........

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Section: Discussionmentioning

confidence: 73%

Histopathological Outcome of Oral Lesions in Pakistani Population with Special Emphasis on Oral Cancer

Waheed

Sarfraz

Kaleem

et al. 2022

PAFMJ

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“…Concerning the possible viral etiology of the disease, PV was the most commonly virus scanned and identified in cats with oral SSC and on FOSCC samples. In humans, an association between HPV16/18 and HNSCC is described [ 15 , 16 ]. Similarly, some authors report a possible association between a chronic infection with canine papillomavirus and the malignant transformation of lesions in SCC, in particular, the transformation of oral papilloma in oral SCC [ 17 , 18 , 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Feline Oral Squamous Cell Carcinoma: A Critical Review of Etiologic Factors

Sequeira

Pires

Leitão

et al. 2022

Veterinary Sciences

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Feline oral squamous cell carcinoma (FOSCC) is the most common oral neoplasia in cats. This malignant tumor is locally invasive, has a high mortality rate, and its etiology is not yet known. In humans, head and neck squamous cell carcinoma is associated with tobacco smoke, alcohol consumption, and human papillomavirus infection. Herein, a critical review about the potential etiologic factors of FOSCC was performed, considering publications between 2000 and 2022, aiming to synthesize all available scientific evidence regarding this issue. Recommendations of the PRISMA statement and the Cochrane Collaboration were followed and the PubMed database searched by using the MeSH terms MeSH terms “oral”, “mouth”, “lingual”, “labial”, “gingiva”, “carcinoma”, “squamous”, and “feline”. The selection process for eligible studies was based on specific inclusion and exclusion criteria and the quality of the studies assessed. The initial search resulted in 553 publications, with only 26 of these being included in the review. Sixteen studies were related to viral etiology and nine related to environmental factors such as exposure to tobacco smoke, ectoparasitic products, and the presence of oral comorbidities. When evaluated, feline papillomavirus was detected in 16.2% of samples of FOSCC. In the three studies focused on exposure to tobacco smoke, 35.2% (30/85) of cats with FOSCC had a history of this exposure. The consumption of canned food and the use of deworming collars were associated, in only one publication, with a risk of neoplasia increased by 4.7 and 5.3 times, respectively. Among 485 cats with FOSCC, 6.4% had dental and oral pathology (i.e., periodontal disease or feline chronic gingivostomatitis). The present study demonstrates that the available evidence on the etiology of FOSCC is still limited, however, there has been an increasing interest on this topic. To better understand the role of the possible etiological factors of this aggressive disease, and model for its human counterpart, large, prospective multi-institutional studies are needed.

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“…On the other hand, the role of cigarette smoking in the etiology of lung neoplastic transformation is well documented [ 24 - 25 ]. Cigarette smoking is prevalent in Saudi Arabia, especially amongst the younger generation [ 26 ], which necessitates urgent tobacco prevention control measures at community levels.…”

Section: Discussionmentioning

confidence: 99%

The Utility of Nucleolar Organizer Regions Quantitation in Early Prediction of Lung Neoplastic Transformation

Ahmed

Hag

Binsaleh

et al. 2020

Cureus

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Background: Cancer burden can be reduced by early detection of early neoplastic changes applying suitable screening methods. This study aimed to assess the utility of nucleolar organizer regions (NORs) quantitation in early prediction of lung neoplastic transformation. Methodology: This study investigated 200 apparently healthy individuals categorized into two groups; smoking exposed individuals (N=100), and were categorized as cases, and smoking nonexposed (N=100), and were ascertained as controls. Sputum specimen was attained from each participant (paying all indispensable safety precautions and sample adequacy processes). Results: Out of the 200 volunteers assessed in the present study, mean NORs counts of >2.00 were identified in 16/200(8%) of the study subjects. All 16/16(100%) cases were found with lung epithelial metaplasia (squamous metaplasia). Out of the 100 cases, mean NORs counts of >2.00 were identified in 16/100(16%), hence, all the controls were identified with mean NORs counts of <2.00. The risk of lung cellular proliferative changes associated with smoking exposure are odds ratio (OR) (95% confidence interval, CI) = 39.2485 (2.3199-664.0052), p = 0.0110, z statistic = 2.543. Conclusion: NORs count is a simple, specific, cost-effective, and reliable method that can give a quantitative measurement for the risk of lung neoplastic transformation. For at risk-population (tobacco users), it is recommended to perform the argyrophilic NORs (AgNORs) method beside sputum cytology.

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Oral and Oropharyngeal Cancers and Possible Risk Factors Across Gulf Cooperation Council Countries: A Systematic Review

Cited by 19 publications

References 53 publications

Histopathological Outcome of Oral Lesions in Pakistani Population with Special Emphasis on Oral Cancer

Histopathological Outcome of Oral Lesions in Pakistani Population with Special Emphasis on Oral Cancer

Feline Oral Squamous Cell Carcinoma: A Critical Review of Etiologic Factors

The Utility of Nucleolar Organizer Regions Quantitation in Early Prediction of Lung Neoplastic Transformation

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