Oral and oropharyngeal squamous cell carcinoma in young patients: The Netherlands Cancer Institute experience

Abstract

In this series, patients younger than 40 years with oral and oropharyngeal SCC showed no significant difference in DSS compared with patients older than 40 years, even when adjusted for tobacco and alcohol consumption.

Survival Analysis of Oral Squamous Cell Carcinoma in a Subgroup of Young Patients

“…Our own observations indicate a 75.5% 5-year overall survival rate and a 61.5 % 5-year local-regional control rate, which consistent with some other published series over the decade showing the relatively better survival rate among young group (Llewellyn et al, 2001;van Monsjou et al, 2013). However, it would be take into account tumour stage and site, type of treatment and a more comprehensive examination of risk factors when considering true better survivial rate difference among studies.…”

“…However, data regarding prognosis are conflicting. Some investigators have proposed that a more favorable clinical outcome of young adults should be expected, with an average 5-year survival rate of 65 % or even better (van Monsjou et al, 2013). Moreover, this subset of patients may benefit form more aggressive surgical resections facilitated by modern reconstructive methods in recent decades and better tolerance of radiotherapy and chemotherapy with less side effects (Kies et al, 2012).…”

“…Several differences have been identified for the clinic-pathological profile of patients with early-onset OSCC, suggesting that oral cancer in the young may be distinct from that occurring in older patients with a different etiology and disease progression (Chang et al, 2013;van Monsjou et al, 2013). Nevertheless, Asian countries have distinct cultural practices such as betel chewing and varying patterns of use of tobacco and alcohol (Krishna et al, 2014).…”

Lack of Association between High-risk Human Papillomaviruses and Oral Squamous Cell Carcinoma in Young Japanese Patients

“…However, a correlation between HPV and OSCC has not been established. For example, there are discrepancies in the prevalence of HPV in patients with OSCC residing in different regions worldwide (El-Mofty and Lu, 2003;Lopes, 2011;Duray, 2012;Kaminagakura, 2012;Lingen, 2013;Reuschenbach, 2013;van Monsjou, 2013). Moreover, patients residing in Japan exhibit a wide range for HPV prevalence (0-78%) (Shima, 2000;Kojima, 2002;Sugiyama, 2007;Kabeya, 2012).…”

Primary adenocarcinoma of the base of tongue: a rare case

“…[4] On the other hand, adenocarcinoma, a common histopathological type for digestive system, is very rarely reported at this region, even though oropharynx is accepted as a part of digestive system. In literature, there is lim- …”