Oral and perioral herpes simplex virus type 1 (HSV‐1) infection: review of its management*

Abstract

Herpes simplex virus type 1 (HSV-1) gives rise to a variety of clinical disorders and is a major cause of morbidity and mortality worldwide. HSV-1 infections are common in oral and perioral area. The aim of the present report was to critically examine the published literature to evaluate the advantages and limitations of therapy of HSV-1 infection in both immunocompetent and immunocompromised patients. Systemic antiviral therapy has been widely accepted as effective for primary herpetic gingivostomatitis. Aciclovir (ACV) 5% cream seems to be the accepted standard topical therapy for herpes labialis, being both effective and well tolerated, although penciclovir 1% cream has been proposed as a potentially useful treatment. Systemic ACV may be effective in reducing the duration of symptoms of recurrent HSV-1 infection, but the optimal timing and dose of the treatment are uncertain. Aciclovir and famciclovir may be of benefit in the acute treatment of severe HSV-1 disease in immunocompromised patients. There is also evidence that prophylactic oral ACV may reduce the frequency and severity of recurrent attack of herpetic infection in immunocompromised patients, but the optimal timing and duration of treatment is uncertain and can vary in different situations.

Pentagalloylglucose Blocks the Nuclear Transport and the Process of Nucleocapsid Egress to Inhibit HSV-1 Infection

“…Herpes simplex virus type 1 (HSV-1), belonging to the Herpesviridae family, the Alphaherpesvirinae subfamily and genus Simplexvirus, was the first human herpes virus to be discovered (1). HSV-1 is a linear doublestranded DNA virus that primarily affects the mucocutaneous surfaces but can also infect the visceral organs or the central nervous system (2).…”

Estudio Comparativo entre Terapia con Melissa officinalis vs. Tratamiento Convencional con Aciclovir Tópico al 5% para Lesiones Herpéticas Tipo 1

“…Es causada por el virus herpes hominis de tipo I (VHS-1) y puede erupcionar en cualquier parte del cuerpo, particularmente en la boca y los genitales acompañada de ardor y prurito (Manzur et al, 2002), aunque en su expresión más compleja puede derivar en fiebre, confusión, coma y signos neurales focalizados (Reyes Romero et al, 2012) El herpes simple (HVS) es un virus de cadena simple de ADN (Arduino & Porter, 2006) rodeada de capas de proteínas y una envoltura de lipoproteínas de una forma esférica con un diámetro de 150 a 200 nm (Reyes Romero et al) es de carácter neurotrópico, el cual infecta nervios periféricos y emigra a un ganglio nervioso regional donde permanece en estado de latencia encontrándose protegido del sistema inmune y agentes terapéuticos (Arduino & Porter).…”

Herpes virus infection in dermatology: problems and modern approach to treatment

“…Среди всех гер-пес-вирусов наиболее часто встречаются члены под-семейства Alphaherpesvirinae: вирус простого герпеса 1-го и 2-го типов (ВПГ-1 и ВПГ-2; Herpes simplex virus-1 и Herpes simplex virus-2), вызывающие фаци-альные (лабиальные, орофациальные) и гениталь-ные поражения кожи и слизистых, а также вирус Varicella zoster (Human herpesvirus-3), являющийся этиологическим фактором ветряной оспы и опоя-сывающего лишая [2][3][4].…”