Oral and pharyngeal cancer in the North-west and West Yorkshire regions of England, and occupation.

Whitaker, C. J.; Moss, Esther L.; Lee, William R.; Cunliffe, S

doi:10.1136/oem.36.4.292

Cited by 10 publications

(7 citation statements)

References 7 publications

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“…Some of the suggested associations with categories of production workers also confirmed the results of previous reports. Oral and pharyngeal cancer risk has been associated with work in the textile and apparel manufacturing industry (19)(20)(21)(22)(23)(24), even if other reports (25,26) did not confirm the finding. Machinists and metal working machine operators (18,27), miners (24), workers in the building industry (24), painters (18), plumbers (27), printers (15,28), electronics manufacturing workers (26,29) and electricity production workers (30), and different categories of railway workers (13,15) have previously been suggested to be at increased risk.…”

Section: Discussioncontrasting

confidence: 43%

Occupation and cancer of the oral cavity or oropharynx in Turin, Italy.

Merletti¹,

Boffetta²,

Ferro³

et al. 1991

Scand J Work Environ Health

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TERRACINI B. Occupation and cancer of the oral cavity or oropharynx in Turin, Italy. Scand J Work Environ Health 1991;17:248-54. In a population-based case-referent study, the occupational experience of 86 men with oral or oropharyngeal cancer and 373 referents was analyzed with respect to employment in 41 occupations and 40 industries, as well as to exposure to 16 chemicals, as estimated via a job-exposure matrix. Among the occupations and industries at higher risk were machinery operator (odds ratio [OR] 2.0; 95 % confidence interval [95 0/0 CI] 1.0-4.0), plumber (OR 5.0,95 % CI 1.2-21.5), building industry (OR 2.5; 95 % CI 1.3-4.5), textile industry (OR 2.5; 95 % CI 0.6-4.6), and electricity production (OR 2.8; 95 OTo CI 0.7-12.1) . All the OR estimates were adjusted for age, education, area of birth, tobacco smoking, and alcohol consumption. An association between formaldehyde exposure and oral cancer was suggested (OR for any exposure 1.6, 95 OTo CI 0.9-2.8; OR for probable or definite exposure 1.8,. No other chemical included in the matrix showed any risk pattern. The evidence of an association between formaldehyde exposure and oral or oropharyngeal cancer is strengthened by the results of this study .

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Section: Discussioncontrasting

confidence: 43%

Occupation and cancer of the oral cavity or oropharynx in Turin, Italy.

Merletti¹,

Boffetta²,

Ferro³

et al. 1991

Scand J Work Environ Health

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“…Relationships with both alcohol In our study 9 either mode1 adequately described the and smoking have been well documented in other data. To distinguish between them empirically in hustudies (Grahametal., 1977;Wynderetal., 1956Wynderetal., ,1957, man studies is difficult as in this population as in most 1976; Bross and Coombs, 1976;Feldman and Boxer, others smoking and alcohol consumption are highly 1979;Herity et al, 1981;Hinds et al, 1979;Keller and Terris, 1965;Martinez, 1969;Rothman and Keller, Our results show that smoking is a less important 1972; Smith, 1979;Whitaker et al, 1979). Our results factor than alcohol consumption.…”

Section: Smoking Ciddaymentioning

confidence: 59%

“…Mashberg and Meyers (1976) in a prospective study showed no direct association of the site of dental irritation with that of the tumour. Less detailed studies assessing the use of dentures or edentia have been inconsistent (Whitaker et al, 1979;Herity etal., 1981). Wynder el al.…”

Section: Smoking Ciddaymentioning

confidence: 99%

Alcohol, smoking, social and occupational factors in the aetiology of cancer of the oral cavity, pharynx and larynx

Elwood

Pearson

Skippen

et al. 1984

Intl Journal of Cancer

270

108

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A case-control study of 374 patients with primary epithelial cancers of the oral cavity, oro- and hypopharynx, and larynx is reported, the controls being patients with selected other cancers, matched for age and sex. Of all eligible patients, 93% were interviewed. Increased risks were seen with alcohol consumption and, less strongly, with smoking, which for all sites could be adequately fitted by either a multiplicative or an additive model. However, the site-specific relationships were different, alcohol consumption being significantly associated only with oral cavity, pharyngeal and extrinsic laryngeal tumours, and smoking only with intrinsic laryngeal tumours. Increased risks were associated with low socio-economic status, the unmarried state, and poor dental care. No significant associations were seen with specific occupational exposures.

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“…Similarly, although some authors have found an increased risk of laryngeal or pharyngeal cancers among textile workers,7-9 47 other studies have failed to confirm these results 1335 39 48 Moreover, most textile or wood workers are exposed not only to wood dust or textile dust, but also to numerous other substances, including solvents, varnishes, dyes, asbestos, and formaldehyde 3749 50These other substances can all be potential confounders in studies based on job titles.…”

Section: Discussionmentioning

confidence: 99%

Laryngeal and hypopharyngeal cancers and occupational exposure to formaldehyde and various dusts: a case-control study in France

Laforest

Luce²,

Goldberg³

et al. 2000

Occup Environ Med

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Objectives-A case-control study was conducted in France to assess possible associations between occupational exposures and squamous cell carcinomas of the larynx and hypopharynx. Methods-The study was restricted to men, and included 201 hypopharyngeal cancers, 296 laryngeal cancers, and 296 controls (patients with other tumour sites). Detailed information on smoking, alcohol consumption, and lifetime occupational history was collected. Occupational exposure to seven substances (formaldehyde, leather dust, wood dust, flour dust, coal dust, silica dust, and textile dust) was assessed with a job exposure matrix. Exposure variables used in the analysis were probability, duration, and cumulative level of exposure. Odds ratios (ORs) with their 95% confidence intervals (95% CIs) were estimated by unconditional logistic regression, and were adjusted for major confounding factors (age, smoking, alcohol, and when relevant other occupational exposures). Results-Hypopharyngeal cancer was found to be associated with exposure to coal dust (OR 2.31, 95% CI 1.21 to 4.40), with a significant rise in risk with probability (p<0.005 for trend) and level (p<0.007 for trend) of exposure. Exposure to coal dust was also associated with an increased risk of laryngeal cancer (OR 1.67, 95% CI 0.92 to 3.02), but no doseresponse pattern was found. A significant relation, limited to hypopharyngeal cancer, was found with the probability of exposure to formaldehyde (p<0.005 for trend), with a fourfold risk for the highest category (OR 3.78 , 95% CI 1.50 to 9.49). When subjects exposed to formaldehyde with a low probability were excluded, the risk also increased with duration (p<0.04) and cumulative level of exposure (p<0.14). No significant association was found for any other substance. Conclusion-These results indicate that exposure to formaldehyde and coal dust may increase the risk of hypopharyngeal cancer. (Occup Environ Med 2000;57:767-773)

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Oral and pharyngeal cancer in the North-west and West Yorkshire regions of England, and occupation.

Cited by 10 publications

References 7 publications

Occupation and cancer of the oral cavity or oropharynx in Turin, Italy.

Occupation and cancer of the oral cavity or oropharynx in Turin, Italy.

Alcohol, smoking, social and occupational factors in the aetiology of cancer of the oral cavity, pharynx and larynx

Laryngeal and hypopharyngeal cancers and occupational exposure to formaldehyde and various dusts: a case-control study in France

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