Oral and subcutaneous absorption of insulin poly(isobutylcyanoacrylate) nanoparticles

Mesiha, Mounir S.; Sidhom, Madiha B.; Fasipe, Babatunde

doi:10.1016/j.ijpharm.2004.10.003

Cited by 63 publications

(25 citation statements)

References 10 publications

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“…Nanoparticles with average particle size below 100 nm obtained in the presence of 2.5% pluronic acid were utilized for in vivo bioavailability studies in streptozocininduced diabetic rats. Fast hypoglycemic effect was achieved 2 h after administration and was sustained over 40 h (28).…”

Section: Anionic Polymerization For Fabrication Of Nanoparticlesmentioning

confidence: 97%

“…The cyano groups are quite efficient as stabilizing substituents such that even water can initiate the polymerization of cyanoacrylate. Mesiha et al developed insulinloaded poly(isobutylcyanoacrylate) nanoparticles by in situ anionic polymerization (28). Insulin solution (pH 7.42) was added to an aqueous solution of pluronic acid and 5% w/v citric acid; isobutylcyanoacrylate was added dropwise into the solution and agitated for 4 h at ambient temperature.…”

Section: Anionic Polymerization For Fabrication Of Nanoparticlesmentioning

confidence: 99%

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Application of In Situ Polymerization for Design and Development of Oral Drug Delivery Systems

Ngwuluka

2010

AAPS PharmSciTech

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Abstract. Although preformed polymers are commercially available for use in the design and development of drug delivery systems, in situ polymerization has also been employed. In situ polymerization affords the platform to tailor and optimize the drug delivery properties of polymers. This review brings to light the benefits of in situ polymerization for oral drug delivery and the possibilities it provides to overcome the challenges of oral route of administration.

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Section: Anionic Polymerization For Fabrication Of Nanoparticlesmentioning

confidence: 97%

Section: Anionic Polymerization For Fabrication Of Nanoparticlesmentioning

confidence: 99%

Application of In Situ Polymerization for Design and Development of Oral Drug Delivery Systems

Ngwuluka

2010

AAPS PharmSciTech

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“…Numerous strategies have been devised to enhance insulin absorption. Nanoparticles as a drug delivery system have been found to be useful in protecting and/or prolonging insulin effect (Damgé, Maincent, and Ubrich 2007;Jerry et al 2001;Mesiha, Sidhom, and Fasipe 2005). In the nanotechnology field, polymeric biomaterials have been received increasing attention, especially gastric and proteolytic protective polymers.…”

mentioning

confidence: 99%

Polyelectrolyte Biomaterial Interactions Provide Nanoparticulate Carrier for Oral Insulin Delivery

et al. 2008

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“…(Sinha et al, 2004). Microparticulate systems have been developed for oral (Rekha & Sharma, 2009), topical (Zhao et al, 2010), parenteral (Mesiha et al, 2005) and nasal routes. Literature abounds with the studies that report various type of microparticulate systems, such as magnetic microparticles, solid lipid microparticles, biological microparticles, metal based and polymeric microparticles (Table 3) (Pereswetoff-Morath, 1998;Sinha et al, 2004;Bilati et al, 2005;Hughes, 2005;Dash & Konkimalla, 2011).…”

Section: Microparticulate Systemsmentioning

confidence: 99%

Novel drug delivery system: an immense hope for diabetics

et al. 2014

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Context: Existing medication systems for the treatment of diabetes mellitus (DM) are inconvenient and troublesome for effective and safe delivery of drugs to the specific site. Therefore, investigations are desired to deliver antidiabetics using novel delivery approaches followed by their commercialization. Objective: The present review aims to provide a compilation on the latest development in the field of novel drug delivery systems (NDDSs) for antidiabetics with special emphasis on particulate, vesicular and miscellaneous systems. Methods: Review of literature (restricted to English language only) was done using electronic databases like Pubmed Õ and Scirus, i.e. published during [2005][2006][2007][2008][2009][2010][2011][2012][2013]. The CIMS/MIMS India Medical Drug Information eBook was used regarding available marketed formulation of antidiabetic drugs. Keywords used were ''nanoparticle'', ''microparticle'', ''liposomes'', ''niosomes'', ''transdermal systems'', ''insulin'', ''antidiabetic drugs'' and ''novel drug delivery systems''. Single inclusion was made for one article. If in vivo study was not done then article was seldom included in the manuscript. Results: The curiosity to develop NDDSs of antidiabetic drugs with special attention to the nanoparticulate system followed by microparticulate and lipid-based system is found to emerge gradually to overcome the problems associated with the conventional dosage forms and to win the confidence of end users towards the higher acceptability. Conclusion: In the current scientific panorama when the area of novel drug delivery system has been recognized for its palpable benefits, unique potential of providing physical stability, sustained and site-specific drug delivery for a scheduled period of time can open new vistas for precise, safe and quality treatment of DM.

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Oral and subcutaneous absorption of insulin poly(isobutylcyanoacrylate) nanoparticles

Cited by 63 publications

References 10 publications

Application of In Situ Polymerization for Design and Development of Oral Drug Delivery Systems

Application of In Situ Polymerization for Design and Development of Oral Drug Delivery Systems

Polyelectrolyte Biomaterial Interactions Provide Nanoparticulate Carrier for Oral Insulin Delivery

Novel drug delivery system: an immense hope for diabetics

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