Oral application of carbon nanofibers in rats increases blood concentration of IL6 and IL10 and decreases locomotor activity

Sayapina, Nina Vitalievna; Batalova, T. A.; Сергиевич, А. А.; Shtarberg, M.A.; Borodin, E.A.; Khoroshikh, Pavel P.; Чайка, Владимир; Kodintsev, Vladimir; Vedyagin, Aleksey A.; Mishakov, Ilya V.; Vakis, Antonis; Henrich‐Noack, Petra; Tsatsakis, Aristidis; Engin, Ayşe Başak; Golokhvast, Kirill S.

doi:10.1016/j.etap.2017.01.015

Cited by 7 publications

(5 citation statements)

References 42 publications

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“…IL-1β plays a vital role in mediating the cellular inflammation like apoptosis, differentiation, and proliferation. 45 Increases in the level of IL-1β are known to act as an autocrine growth factor for various cancers. TNF-α and IL-1β has the evidence to cause upregulation of the liver metastasis, vascular cell adhesion, and cancer in tissues.…”

Section: Discussionmentioning

confidence: 99%

“…TNF‐α and IL‐6 is known to be elevated during stress and inflammation of the tissues. IL‐1β plays a vital role in mediating the cellular inflammation like apoptosis, differentiation, and proliferation . Increases in the level of IL‐1β are known to act as an autocrine growth factor for various cancers.…”

Section: Discussionmentioning

confidence: 99%

“…IL-1β plays a vital role in mediating the cellular inflammation like apoptosis, differentiation, and proliferation. 45 Increases in the level of IL-1β are Comparisons were made as follows: a-Group-I vs groups-II, III, IV, V; b-Group-II vs Group-III, IV, V; c-Group-III vs Group-IV, V; d-Group-IV vs Group-V. The symbols represent statistical significance at *P < 0.05.…”

Section: Figurementioning

confidence: 99%

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Aqueous leaves extract of Madhuca longifolia attenuate diclofenac‐induced hepatotoxicity: Impact on oxidative stress, inflammation, and cytokines

Simon

Sabina

2018

J of Cellular Biochemistry

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Diclofenac is a Non-Steroidal Anti-inflammatory drug which is used as an analgesic. It is known to cause heptotoxicity on over dose and long term usage. Madhuca longifolia is an evergreen tree found widely in India that is known to have several ethnomedical uses. The aim of our study is to evaluate the beneficial effect of the aqueous leaf extract of M. longifolia against diclofenac-induced toxicity. Rats were dived into five groups of six rats each. Group-I was normal control. Group-II was administered with diclofenac (50 mg/kg. b.w./day, i.p) on 4th and 5th day. Group-III rats were treated with aqueous leaf extract of M. longifolia (500 mg/kg b.w./day, oral) for 5 consecutive days and diclofenac (50 mg/kg. b.w./day, i.p) was given on 4th and 5th day. Silymarin (25 mg/kg. b.w./day, oral) was used as standard drug which was given to the rats of group-IV along with diclofenac on 4th and 5th day. Aqueous leaf extract of M. longifolia (500 mg/kg b.w./day, oral) alone was administered in group-V. After the study period, the rats were evaluated for liver enzyme markers, antioxidant parameters, histopathological changes, and cytokines levels. The hepatic proinflammatory mediator cytokines like TNF-α, IL-6, and IL-1β were evaluated through ELISA. The protein expression of Caspase-3, COX-2, and NF-κB were analysed through Western blotting techniques. Aqueous leaves extract of M. longifolia was able to normalize the changes caused by diclofenac. Current study indicatesthe protective effect of the aqueous leaves extract of M. longifolia against diclofenac-induced toxicity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Aqueous leaves extract of Madhuca longifolia attenuate diclofenac‐induced hepatotoxicity: Impact on oxidative stress, inflammation, and cytokines

Simon

Sabina

2018

J of Cellular Biochemistry

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“…Furthermore, there have been no reported studies utilizing TG407 for nano bers administered orally. Additionally, research on the safety of orally administered nano bers has typically been limited to two weeks or low concentrations 16,17) . As a result, this study aimed to assess the safety of orally administered b-CNF through an acute toxicity study in rats in accordance with the OECD guidelines laid out in TG407 for four weeks.…”

Section: Introductionmentioning

confidence: 99%

28-day repeated oral administration study of mechanically fibrillated cellulose nanofibers (fib-CNF) according to OECD TG407

Yamashita,

Tokunaga,

Aoki

et al. 2023

Preprint

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It is still unclear whether oral administration of mechanically fibrillated cellulose nanofibers (hereafter, fib-CNF), which is widely used among nanofibers, causes toxicity or, on the contrary, improves health, despite the reported safety and even beneficial effects of oral intake of chitin-based nanofibers. Therefore, it is crucial to adhere to the guidelines outlined in OECD TG407 for the evaluation of oral toxicity. This study aimed to assess the safety of orally administered fib-CNF through an acute toxicity study in rats in accordance with the OECD guidelines laid out in TG407 for four weeks. CNF "BiNFi-s" FMa-10005, obtained through the mechanical defibrillation of pulp-derived cellulose, was administered via forced oral administration to male and female Crl:CD(SD) rats at doses of 50, 150, 500, and 1000 mg/kg/day for a period of 28 days in a control group (vehicle: water for injection). The study aimed to assess the toxic effects of repeated administration, and the rats were also monitored for 14 days after the administration to evaluate the recovery from any toxic effects. Results indicate that no deaths occurred in either sex during the administration period, and no toxicological effects related to the test substance were observed in various assessments, including general condition and behavioral function observations, urinalysis, hematological examination, blood biochemical examination, necropsy findings, organ weights, and histopathological examination. Notably, only female rats treated with 1000 mg/kg/day of CNF exhibited a consistent reduction in body weight during the 14-day recovery period after the end of treatment. They also showed a slight decrease in pituitary and liver weights. However, hematological and blood biochemical tests did not reveal significant differences, suggesting a potential weight-suppressive effect of CNF ingestion.

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“…At the same time, it was reported that carbon nanomaterials can penetrate the environment and accumulate in tissues of organisms, in bottom sediments, and in various parts of food chains [ [20] , [21] , [22] ]. The other area that required more research is the toxic influence of carbon nanomaterials on benthic aquatic invertebrates, inhabiting the bottom layers of reservoirs.…”

Section: Introductionmentioning

confidence: 99%

The toxic influence and biodegradation of carbon nanofibers in freshwater invertebrates of the families Gammaridae, Ephemerellidae, and Chironomidae

et al. 2020

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Oral application of carbon nanofibers in rats increases blood concentration of IL6 and IL10 and decreases locomotor activity

Cited by 7 publications

References 42 publications

Aqueous leaves extract of Madhuca longifolia attenuate diclofenac‐induced hepatotoxicity: Impact on oxidative stress, inflammation, and cytokines

Aqueous leaves extract of Madhuca longifolia attenuate diclofenac‐induced hepatotoxicity: Impact on oxidative stress, inflammation, and cytokines

28-day repeated oral administration study of mechanically fibrillated cellulose nanofibers (fib-CNF) according to OECD TG407

The toxic influence and biodegradation of carbon nanofibers in freshwater invertebrates of the families Gammaridae, Ephemerellidae, and Chironomidae

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