Oral Bioaccessibility and Leaching: Tests for Soil Risk Assessment

Hansen, Jette Bjerre; Oomen, Agnes G.; Edelgaard, I.; Grøn, C.

doi:10.1002/elsc.200620174

Cited by 16 publications

(12 citation statements)

References 8 publications

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“…The key contaminants included in this work are arsenic (As), lead (Pb) and cadmium (Cd) as they are potentially harmful to human health (ATSDR, 2007b;ATSDR, 2007a;ATSDR, 2008) and the most common elements undergoing bioaccessibility research Ruby et al, 1993;Ruby et al, 1996;Albores et al, 2000;Oomen et al, 2002;Marschner et al, 2006;Chan et al, 2007;Datta et al, 2007;Drexler and Brattin, 2007;Finzgar et al, 2007;Hansen et al, 2007;Juhasz et al, 2007aJuhasz et al, , 2007bLjung et al, 2007;Sarkar et al, 2007;Subacz et al, 2007;Turner and Ip, 2007;Van de Wiele et al, 2007;Beak et al, 2008;Moseley et al, 2008;Girouard and Zagury, 2009;Morman et al, 2009;Nagar et al, 2009;Poggio et al, 2009;Smith et al, 2009;Zhang et al, 2009;Demetriades et al, 2010;Juhasz et al2010). …”

Section: Introductionmentioning

confidence: 99%

An inter-laboratory trial of the unified BARGE bioaccessibility method for arsenic, cadmium and lead in soil

Wragg

Cave

Basta

et al. 2011

Science of The Total Environment

168

202

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The Bioaccessibility Research Group of Europe (BARGE) has carried out an interlaboratory trial of a proposed harmonised in vitro physiologically based ingestion bioaccessibility procedure for soils, called the Unified BARGE Method (UBM). The UBM includes an initial saliva phase and simulated stomach and intestine compartments. The trial involved the participation of seven laboratories (five European and two North American) providing bioaccessibility data for As (11 samples), Cd (9 samples) and Pb (13 samples) using soils with in vivo relative bioavailability data measured using a swine model. The results of the study were compared with benchmark criteria for assessing the suitability of the UBM to provide data for human health risk assessments. Mine waste and slag soils containing high concentrations of As caused problems of poor repeatability and reproducibility which were alleviated when the samples were run at lower soil to solution ratios. The study showed that the UBM met the benchmark criteria for both the stomach and stomach & intestine phase for As. For Cd, three out of four criteria were met for the stomach phase but only one for the stomach & intestine phase. For Pb two, out of four criteria were met for the stomach phase and none for the stomach & intestine phase. However, the study recommends tighter control of pH in the stomach phase extraction to improve between-laboratory variability, more reproducible in vivo validation data and that a follow up inter-laboratory trial should be carried out.

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Section: Introductionmentioning

confidence: 99%

An inter-laboratory trial of the unified BARGE bioaccessibility method for arsenic, cadmium and lead in soil

Wragg

Cave

Basta

et al. 2011

Science of The Total Environment

168

202

View full text Add to dashboard Cite

show abstract

“…In general, human contact or oral ingestion of soils is described as occasional (Body et al 1999;Pouschat and Zagury 2006;Lemly 2007;Morman et al 2009) and in some cases intentional (Smith et al 2000). Several studies have reported the potential risk caused by oral ingestion of metalpolluted soils (Hansen et al 2007;Denys et al 2008;US EPA 2009). The potential risk of ingestion of metal contaminants is currently assessed through bioaccessibility approaches, understanding bioaccessibility as the fraction representing the availability of metal absorption when dissolved in surrogates of body fluids or juices after oral exposure.…”

Section: Introductionmentioning

confidence: 98%

“…The potential risk of ingestion of metal contaminants is currently assessed through bioaccessibility approaches, understanding bioaccessibility as the fraction representing the availability of metal absorption when dissolved in surrogates of body fluids or juices after oral exposure. In this regard, several in vitro tests that simulate gastrointestinal conditions have been proposed to estimate the bioaccessibility of some elements from ingested soils (Carrizales et al 2006;Intawongse and Dean 2006;Ljung et al 2007;Hansen et al 2007;Makris et al 2008;Bosso and Enzweiler 2008;Madrid et al 2008;Smith et al 2009;Zagury et al 2009;Morman et al 2009). To date, Se has not been addressed.…”

Section: Introductionmentioning

confidence: 98%

Comparison of In Vitro PBET and Phosphoric Acid Extraction as an Approach to Estimate Selenite and Selenate Bioaccessibility from Soil

Funes-Collado

Rubio

López-Sánchez

2011

Water Air Soil Pollut

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Several approaches have been used to estimate the bioaccessibility of trace metals from soils. Here, we applied phosphoric acid extraction and the in vitro test physiologically based extraction (PBET) to soils containing selenium (Se) and compared their performance in estimating the bioaccessibility of Se. For this purpose, we used two soil samples and two Certified Reference Material soil samples with a range of Se concentrations. The total Se contents were measured in the samples and in the extracts by hydride generation-atomic fluorescence spectroscopy. Moreover, we also measured selenite and selenate in the soil extracts (from phosphoric acid and from the PBET) using the coupled techniques liquid chromatography-UV photooxidation-atomic fluorescence spectroscopy and liquid chromatographymass spectrometry with inductively coupled plasma. From the results obtained in the present study, the PBET showed that the selenium bioaccessible fraction was mainly attributed to the gastrointestinal step. When comparing the results from PBET with those of the phosphoric acid extraction, similar values of Se (IV) and Se (VI) were obtained for both extraction systems. An estimation of the bioaccessibility percentage of Se is also reported.

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“…Grøn et al (2007) and Hansen et al (2007) estimated maximum bioaccessibility (25-40 %) at lowest "humic content" (2 %) and lower bioaccessibility (6-24 %) at 4-5 % "humic content." However, simply scaling PAH bioaccessibility to SOC content cannot explain the variations in bioaccessibility data from reported soil samples (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Impact of reference geosorbents on oral bioaccessibility of PAH in a human in vitro digestive tract model

Meyer

Kons

Achten

2014

Environ Sci Pollut Res

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Former studies on human oral bioaccessibility of polycyclic aromatic hydrocarbons (PAH) from natural soil samples using human in vitro digestive tract models (physiologically based extraction tests, PBET) show highly variable results (0-100% of mobilized PAH). Apart from other factors, the type and amount of present geosorbents are assumed to be significant for the degree of desorption/release of PAH into the digestive juice. Therefore, in this study, the reference geosorbents pure quartz sand, Na-montmorillonite clay, Pahokee peat, and charcoal "Sommerhit" were spiked with selected deuterated PAH and employed as single materials in a PBET. Lowest bioaccessibility was determined in charcoal, representing black carbon (0.1 ± 0.1 % for ∑10 PAH-d) in contrast to higher bioaccessibility in peat (6.4 ± 2.2%) and clay (4.8 ± 1.1%). Highest bioaccessibility was determined in sand (26.9 ± 7.5%). The results show a systematic impact of heterogeneous geosorbents on human oral bioaccessibility of PAH and particularly black carbon acting as a very strong geosorbent that reduces human health risk.

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Oral Bioaccessibility and Leaching: Tests for Soil Risk Assessment

Cited by 16 publications

References 8 publications

An inter-laboratory trial of the unified BARGE bioaccessibility method for arsenic, cadmium and lead in soil

An inter-laboratory trial of the unified BARGE bioaccessibility method for arsenic, cadmium and lead in soil

Comparison of In Vitro PBET and Phosphoric Acid Extraction as an Approach to Estimate Selenite and Selenate Bioaccessibility from Soil

Impact of reference geosorbents on oral bioaccessibility of PAH in a human in vitro digestive tract model

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