Oral bioavailability of a poorly water soluble HIV-1 protease inhibitor incorporated into pH-sensitive particles: effect of the particle size and nutritional state

Jaeghere, Fanny De; Allémann, Éric; Kübel, Frank; Galli, Bruno; Cozens, Robert; Doelker, Éric; Gurny, Robert

doi:10.1016/s0168-3659(00)00272-8

Cited by 87 publications

(43 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The term 'controlled' is used generically to indicate any device in which some control is exerted over the way in which the bioactive agent is delivered to the tissues once it has been administrated to the patient (Langer, 1991;Silvio et al, 1994;Williams, 1998). This is best exemplified in the concept of thermally and pH-responsive materials, where variation in the temperature/pH discontinuously or sharply changes properties such as volume (De Jaeghere et al, 2000;Kawaguchi, 2000;Morishita et al, 2002). This concept is extremely important, as it can be used as a means to trigger the release of the entrapped bioactive agent, and thus allow control to be exerted over the system.…”

Section: Applications In the Biomedical Field Referencesmentioning

confidence: 99%

Materials in particulate form for tissue engineering. 1. Basic concepts

Silva

Ducheyne

Reis

2007

J Tissue Eng Regen Med

View full text Add to dashboard Cite

For biomedical applications, materials small in size are growing in importance. In an era where 'nano' is the new trend, micro-and nano-materials are in the forefront of developments. Materials in the particulate form aim to designate systems with a reduced size, such as micro-and nanoparticles. These systems can be produced starting from a diversity of materials, of which polymers are the most used. Similarly, a multitude of methods are to produce particulate systems, and both materials and methods are critically reviewed here. Among the varied applications that materials in the particulate form can have, drug delivery systems are probably the most prominent, as these have been in the forefront of interest for biomedical applications. The basic concepts pertaining to drug delivery are summarized, and the role of polymers as drug delivery systems conclude this review. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE R E V I E W A R T I C L E

show abstract

Section: Applications In the Biomedical Field Referencesmentioning

confidence: 99%

Materials in particulate form for tissue engineering. 1. Basic concepts

Silva

Ducheyne

Reis

2007

J Tissue Eng Regen Med

View full text Add to dashboard Cite

show abstract

“…In this sense, nanoparticles made of the poly(methacrylic acid-coethylacrylate) copolymer Eudragit® L100-55 were orally administered to dogs of beagle breed and led to an increase in plasma concentrations due to a specific release of the antiviral near its absorption site. 48 Shah and Amiji 49 demonstrated that It is important to mention that the surface of the described nanoparticles can be tailored to modify the biodistribution of the antiviral to target specific organs and tissues or, with more precision, to deliver the drug to a particular cell type by attachment of ligands that recognize cell surface receptors. 50 All of these facts are easily extrapolated to Ae.…”

Section: Antiviral Drugsmentioning

confidence: 99%

Nanobiotechnology Solutions againstAedes aegypti

Islan

Durán

Castro

2016

Journal of the Brazilian Chemical Society

View full text Add to dashboard Cite

United Nations Children's Fund (UNICEF)/United Nations Development Programme (UNDP)/ World Bank/World Health Organization (WHO) implemented the Training in Tropical Diseases (TDR) program with excellent results; however, due to current challenges, this active program requires new and innovative solutions. Nowadays, Aedes aegyptis-borne diseases can be added among neglected diseases. Surveillance and control must be considered owing to a great risk of infection with dengue, chikungunya and zika viruses. Although investigations on several vaccines are in progress, new insights in term of development of drugs that evade from resistance are of paramount importance. Nanobiotechnology appears as one of the most innovative strategy in the search of new uses for old pharmaceuticals or in the development of innovative and intelligent nanomedicines for neglected diseases. Liposomes, solid lipid nanoparticles, nanoemulsions, polymeric nanoparticles, metallic nanoparticles, quantum dots, carbon dots and carbon nanotubes were the focus of the current advances. In this direction, we have focused this overview on new advances in diagnostic assays as nanobiosensors, antivirus and nanoinsecticides on Aedes aegyptis control.

show abstract

“…21,22 Currently, enteric coating based on Eudragit (poly (methacrylic acid-co-ethylacrylate) copolymers) formulations, which remain impermeable at the low gastric pH and dissolve upon alkaline pH in the small intestine, are extensively employed. 23 Combinations of Eudragit L100-55 or S-100 with other polymers have shown to improve the oral bioavailability and the controlled release of drugs. [24][25][26][27] Shastri et al 28 reported enhanced antigen-specific IgG1 and IgG2a antibodies and protection against live influenza viral challenge after 2 oral immunizations with microparticles containing inactivated influenza A/PR/34/8 H1N1 virus with Eudragit S100 and trehalose.…”

Section: Challenges In the Development Of Oral Vaccine Formulationsmentioning

confidence: 99%