Oral Cancer Treatment Through the Ages: Part 2

Petrosyan, Vahe; Kane, Georgina; Ameerally, Phillip

doi:10.1016/j.joms.2019.01.024

Cited by 3 publications

(3 citation statements)

References 37 publications

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“…Currently, while many environmental agents and physical conditions are established risk factors [5][6][7][8][9][10] for oral cancer (Tables 2 and 3), so they can be easily fought with prevention campaigns (for example against tobacco and alcohol abuse, improving social-economic status, hygienic conditions and adequate sexual behaviors), contemporary physicians and oral surgeons must investigate and learn more about those conditions whose role on oral cancer pathogenesis is still mysterious and unsearched, such as genetic polymorphisms, thinking one step further to possible future oral cancer's management and strategical cellular and molecular techniques against this malignancy, always considering their historic counterparts, in order to avoid past unsuccessful efforts against this kind of tumour [138][139][140][141][142][143][144][145]. It is associated with various types of oral lesions: vulgar wart (HPV-4), papillomas (HPV-11), vulgar warts in HIV+ pts (HPV-7), acuminate condylomata and leukoplakia (HPV-6) and squamous cell carcinoma (HPV-16 >98% is associated and HPV-18)…”

Section: Th Centurymentioning

confidence: 99%

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Oral Cancer: A Historical Review

Inchingolo

Santacroce

Ballini

et al. 2020

IJERPH

107

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Aim: This historical medical literature review aims at understanding the evolution of the medical existence of oral cancer over times, particularly better comprehending if the apparent lower prevalence of this type of cancer in antiquity is a real value due to the absence of modern environmental and lifestyle factors or it is linked to a misinterpretation of ancient foreign terms found in ancient medical texts regarding oral neoplasms. Methods: The databases MedLne, PubMed, Web of Science, Elsevier’s EMBASE.com, Cochrane Review, National Library of Greece (Stavros Niarchos Foundation, Athens) and the Library of the School of Health Sciences of the National and Kapodistrian University of Athens (Greece) were extensively searched for relevant studies published during the past century on the history of oral cancer and its treatment from antiquity to modern times, in addition to the WHO website to analyse the latest epidemiological data. In addition, we included historical books on the topic of interest and original sources. Results: Historical references reveal that the cradle of the oral oncology was in ancient Egypt, the Asian continent and Greece and cancer management was confined to an approximate surgical practice, in order to remove abnormal masses and avoid bleeding with cauterization. In the Medieval Age, little progress occurred in medicine in general, oral cancers management included. It is only from the Renaissance to modern times that knowledge about its pathophysiological mechanisms and histopathology and its surgical and pharmacological treatment approaches became increasingly deep all over the world, evolving to the actual integrated treatment. Despite the abundant literature exploring oncology in past civilizations, the real prevalence of oral cancer in antiquity is much less known; but a literature analysis cannot exclude a consistent prevalence of this cancer in past populations, probably with a likely lower incidence than today, because many descriptions of its aggressiveness were found in ancient medical texts, but it is still difficult to be sure that each single description of oral masses could be associated to cancer, particularly for what concerns the period before the Middle Ages. Conclusions: Modern oncologists and oral surgeons must learn a lot from their historic counterparts in order to avoid past unsuccessful efforts to treatment oral malignancies. Several descriptions of oral cancers in the antiquity that we found let us think that this disease might be linked to mechanisms not strictly dependent on environmental risk factors, and this might guide future research on oral cavity treatments towards strategical cellular and molecular techniques.

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Section: Th Centurymentioning

confidence: 99%

“…From ancient age till 19th century, lack of anaesthesia and antiseptic methodology, airway management and risk of haemorrhage make every surgical approach very hazardous for patient's health. Chemotherapy and radiotherapy in the management of oral cancer was explored in the 20th century [28,138].…”

Section: Hsv-1 (Herpes Simplex Virus Type 1)mentioning

confidence: 99%

Oral Cancer: A Historical Review

Inchingolo

Santacroce

Ballini

et al. 2020

IJERPH

107

View full text Add to dashboard Cite

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“…The dilemma with oral cancer (OC) is that most cases are detected at late stages, costing the country ( Amarasinghe et al, 2019 ). The treatment of OSCC includes surgical intervention, chemotherapy, and radiotherapy ( Petrosyan et al, 2019 ). Complications include dysgeusia and xerostomia associated with salivary gland dysfunction, infectious diseases, and oral mucositis.…”

Section: Introductionmentioning

confidence: 99%

Antitumoral properties of the pomegranate peel and blueberry extracts against tongue carcinoma (in vitro study)

Ahmed,

Esmaeil,

El-Nagdy

et al. 2023

The Saudi Dental Journal

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Radiotherapy in Oral Cancers: Current Perspective and Future Directions

Koushik¹,

Alva²

2022

Oral Cancer - Current Concepts and Future Perspectives

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Oral cancers form one of the most common malignancies seen worldwide, with a steady increase in number over time. Surgery with the addition of adjuvant therapy forms the cornerstone of therapeutic management for these cancers. Despite excellent surgical management, loco-regional recurrences have always been of concern. This has expanded the role of radiotherapy, with concomitant therapies, allowing to establish an effective management protocol. Over the last two decades, there have been huge strides taken towards understanding these specific aspects and providing insight into the most fruitful application of radiotherapy in these patients. In this chapter, we have presented the oncologists perspective to dealing with the non-surgical aspects of oral cancer management. We have elaborated on the chronological order with which radiotherapy has evolved and provided the contemporary aspects of decision making, essential for current practice. The evidence-based approach will address all components of radiotherapy workflow from basic understanding of patient’s anatomy, planning & evaluation during therapy to the outcomes & toxicity profiles to be expected in day-to-day clinics. Established guidelines have been incorporated into the graphical representations to ensure scenario-based understanding. Future perspectives, essential for identifying the possible direction of therapy & potential improvements in outcomes, have also been addressed.

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Oral Cancer Treatment Through the Ages: Part 2

Cited by 3 publications

References 37 publications

Oral Cancer: A Historical Review

Oral Cancer: A Historical Review

Antitumoral properties of the pomegranate peel and blueberry extracts against tongue carcinoma (in vitro study)

Radiotherapy in Oral Cancers: Current Perspective and Future Directions

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